公开(公告)号：EP1958630A1

公开(公告)日：2008-08-20

申请号：EP07102241.2

申请日：2007-02-13

申请人： LEK Pharmaceuticals d.d.

发明人： Prezelj, Andrej ,  Urleb, Uros ,  Solmajer, Tomaz

IPC分类号： A61K31/403 ,  A61K31/427 ,  A61K31/496 ,  A61K31/546 ,  A61P31/00 ,  A61K31/43 ,  A61K31/545

CPC分类号： A61K31/43 ,  A61K31/403 ,  A61K31/427 ,  A61K31/496 ,  A61K31/545 ,  A61K31/546 ,  A61K2300/00

摘要： The invention relates to a pharmaceutical composition comprising an ethylene derivatives of tricyclic carbapenems of the general Formula (I)

in the form of pure diastereoisomers and in the form of pure geometric isomers or a salt, ester or amide derivate thereof and an antibiotic and the use of this composition as a broad band spectrum β-lactamase inhibitior.

摘要翻译： 本发明涉及包含纯非对映异构体形式的通式（I）的三环碳青霉烯的乙烯衍生物和纯几何异构体形式的乙烯衍生物或其盐，酯或酰胺衍生物和抗生素的药物组合物及其用途 的该组合物作为宽带谱β-内酰胺酶抑制剂。

公开(公告)号：EP2307415A1

公开(公告)日：2011-04-13

申请号：EP09765877.7

申请日：2009-06-18

申请人： LEK Pharmaceuticals d.d.

发明人： Plantan, Ivan ,  Prezelj, Andrej ,  Urleb, Uros ,  Mohar, Barbara ,  Stephan, Michel

IPC分类号： C07D477/14 ,  A61K31/40 ,  A61P31/04

CPC分类号： C07D477/14

摘要： The present invention relates to a compound of Formula (I) in particular compounds of formula (Ia), the use of a therapeutically effective amount of one or more compounds of formula (I) or (Ia) as a broad-spectrum antibiotic and the use of a pharmaceutical composition comprising said compounds for the treatment of bacterial infections in humans or animals.

公开(公告)号：EP2085084A1

公开(公告)日：2009-08-05

申请号：EP08150776.6

申请日：2008-01-29

申请人： LEK Pharmaceuticals d.d.

发明人： Prezelj, Andrej ,  Urleb, Uros ,  Vilfan, Gregr

IPC分类号： A61K31/397 ,  A61P31/04 ,  C07D477/00

CPC分类号： C07D477/00 ,  A61K31/397

摘要： The present invention relates to A pharmaceutical composition with broad-spectrum of activity against class A, class C and D enzymes comprising an antibiotic and a pharmaceutically effective amount of a compound of formula (I)

compounds of formula (I), the use of a therapeutically effective amount of one or more compounds of formula (I) as a broad-spectrum beta-lactamase inhibitor and the use of such a pharmaceutical composition for the treatment of an infection in humans or animals caused by bacteria.

摘要翻译： 本发明涉及一种对A类，C类和D类具有广谱活性的药物组合物，其包含抗生素和药学上有效量的式（I）化合物的式（I）化合物，使用 治疗有效量的一种或多种式（I）化合物作为广谱β-内酰胺酶抑制剂，以及这种药物组合物用于治疗由细菌引起的人或动物感染的用途。