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公开(公告)号：EP3281607B1
公开(公告)日：2019-03-06
申请号：EP17185795.6
申请日：2013-06-18
申请人： LifeCell Corporation
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公开(公告)号：EP2776082A1
公开(公告)日：2014-09-17
申请号：EP12791370.5
申请日：2012-11-08
申请人： Lifecell Corporation
发明人： OWENS, Rick , XU, Hui , SUN, Wenquan
摘要： Acellular tissue matrix compositions for use in tissue approximation are provided. Also provided are methods for making and using the compositions to approximate tissue.
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公开(公告)号：EP2696908A1
公开(公告)日：2014-02-19
申请号：EP12716959.7
申请日：2012-04-13
申请人： Lifecell Corporation
CPC分类号： A61L27/24 , A61F2/02 , A61K35/35 , A61K35/545 , A61K38/18 , A61K38/19 , A61L2/081 , A61L2/087 , A61L2/206 , A61L27/20 , A61L27/26 , A61L27/362 , A61L27/3687 , A61L27/3691 , A61L27/3834 , A61L27/54 , A61L27/56 , A61L2430/34 , C08L5/02
摘要： Methods of making tissue fillers are provided. In certain embodiments, the tissue is flake-like and has regenerative properties.
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公开(公告)号：EP3488878A1
公开(公告)日：2019-05-29
申请号：EP18213466.8
申请日：2013-02-26
申请人： LifeCell Corporation
发明人： SUN, Wenquan , YU, Xiaohura
摘要： Devices and methods for treating defects in connective tissue are provided along with methods for making such devices. The devices can include enzyme-activated acellular tissue matrices that facilitate regrowth of the damaged tissue.
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公开(公告)号：EP2822610B1
公开(公告)日：2018-12-26
申请号：EP13708325.9
申请日：2013-02-26
申请人： LifeCell Corporation
发明人： SUN, Wenquan , YU, Xiaohura
CPC分类号： A61K38/4886 , A61L27/24 , A61L27/3604 , A61L27/362 , A61L27/3687 , A61L27/54 , A61L2300/254
摘要： Devices and methods for treating defects in connective tissue are provided along with methods for making such devices. The devices can include enzyme-activated acellular tissue matrices that facilitate regrowth of the damaged tissue.
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公开(公告)号：EP2863840B1
公开(公告)日：2017-08-16
申请号：EP13735107.8
申请日：2013-06-18
申请人： Lifecell Corporation
发明人： ANSORGE, Heather , LAPITAN, Lawrence , HAYZLETT, Mark , KABARIA, Nimesh , HULL, Raymond , SUN, Wenquan , TAENZER, Michael , AMATO, Matthew , ROOCK, Timothy , LEE, Dennis
CPC分类号： A61F2/12 , A61B90/02 , A61F2/0059 , A61F2210/0076 , A61F2220/0016 , A61F2220/0025 , A61F2220/0033 , A61F2220/005 , A61F2220/0075 , A61F2220/0091 , A61F2230/0004 , A61F2230/0045 , A61F2230/0086 , A61F2230/0089 , A61F2230/0093 , A61F2250/0003 , A61F2250/0024 , A61F2250/0031 , A61F2250/0051 , A61F2250/0071
摘要： Improved prostheses comprising a tissue expander and a graft material are disclosed herein. Also disclosed are methods of making prostheses and methods of treatment using the prostheses.
摘要翻译： 1。一种假体，其包括组织扩张器和一个或多个移植材料样本，其中所述组织扩张器以允许组织扩张器和所述一个或多个移植材料样本被植入的方式附接到所述一个或多个移植材料样本 在患者中作为单一假体; 并且其中组织扩张器以允许组织扩张器和移植材料在植入后的一段时间之后分离的方式附接到移植材料的一个或多个样本，以允许从植入部位移除组织扩张器，同时离开 所述植入物部位内的移植物材料，所述假体包括组织扩张器，所述组织扩张器在表面上具有模制的凹槽，槽，通道或其他浅腔空间，并且其中所述移植物材料位于所述凹槽，狭槽，通道或其他浅腔室空间内 将移植材料固定到组织扩张器。
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7.发明公开
公开(公告)号：EP2822610A1
公开(公告)日：2015-01-14
申请号：EP13708325.9
申请日：2013-02-26
申请人： Lifecell Corporation
发明人： SUN, Wenquan , YU, Xiaohura
CPC分类号： A61K38/4886 , A61L27/24 , A61L27/3604 , A61L27/362 , A61L27/3687 , A61L27/54 , A61L2300/254
摘要： Devices and methods for treating defects in connective tissue are provided along with methods for making such devices. The devices can include enzyme-activated acellular tissue matrices that facilitate regrowth of the damaged tissue.
摘要翻译： 提供了用于治疗结缔组织中的缺陷的装置和方法以及用于制造这种装置的方法。 该装置可以包括促进受损组织的再生长的酶激活的无细胞组织基质。
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公开(公告)号：EP4438069A2
公开(公告)日：2024-10-02
申请号：EP24181813.7
申请日：2014-09-05
申请人： LifeCell Corporation
发明人： CHEN, Yi , KABARIA, Nimesh , WANG, Kai-Roy , XU, Hui , LEAMY, Patrick , WAN, Hua , SUN, Wenquan , HUANG, Li Ting
IPC分类号： A61L27/36
CPC分类号： A61L27/3633 , A61L27/3687 , A61L27/3695
摘要： Methods for treating tissue matrices and tissue matrices produced according to the methods are provided. The methods can include treating a tissue matrix with a proteolytic enzyme to produce a desired pliability of the tissue matrix and/or to control the immunogenicity of the tissue matrix. The methods can also comprise performing an assay to determine if contacting the at least one collagen-containing tissue matrix with a proteolytic enzyme has altered the at least one collagen-containing tissue matrix to reduce a human immune response to the tissue matrix. The methods can comprise treatment with alcalase under conditions controlled to produce a desired pliability without unacceptable alteration in collagen structure.
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公开(公告)号：EP2900288B1
公开(公告)日：2018-01-31
申请号：EP13774317.5
申请日：2013-09-25
申请人： Lifecell Corporation
发明人： SUN, Wenquan , LIU, Xianghong
IPC分类号： A61L27/36
CPC分类号： A61L27/3604 , A61F2/12 , A61K35/35 , A61L27/3695 , A61L2430/40
摘要： The present disclosure provides tissue products produced from adipose-containing tissues, as well as methods for producing such tissue products. The tissue products can comprise decellularized and partially de-fatted tissues. In addition, the present disclosure provides systems and methods for using such products.
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公开(公告)号：EP3030272A1
公开(公告)日：2016-06-15
申请号：EP14776766.9
申请日：2014-09-05
申请人： Lifecell Corporation
发明人： CHEN, Yi , KABARIA, Nimesh , WANG, Kai-Roy , XU, Hui , LEAMY, Patrick , WAN, Hua , SUN, Wenquan , HUANG, Li Ting
IPC分类号： A61L27/36
CPC分类号： A61L27/3687 , A61L27/3633 , A61L27/3695
摘要： Methods for treating tissue matrices and tissue matrices produced according to the methods are provided. The methods can include treating a tissue matrix with a proteolytic enzyme to produce a desired pliability of the tissue matrix and/or to control the immunogenicity of the tissue matrix. The methods can also comprise performing an assay to determine if contacting the at least one collagen-containing tissue matrix with a proteolytic enzyme has altered the at least one collagen- containing tissue matrix to reduce a human immune response to the tissue matrix. The methods can comprise treatment with alcalase under conditions controlled to produce a desired pliability without unacceptable alteration in collagen structure.
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