专利检索 ap:("LXR BIOTECHNOLOGY INC.") AND inv:"BARR, Philip, J." 第 1 页

1.

发明公开
NOVEL APOPTOSIS-MODULATING PROTEINS, DNA ENCODING THE PROTEINS AND METHODS OF USE THEREOF 失效
标题翻译： CDN凋亡调节蛋白，YOU编码中使用的DNA和方法

公开(公告)号：EP0731636A1

公开(公告)日：1996-09-18

申请号：EP95904808.0

申请日：1994-11-30

申请人： LXR BIOTECHNOLOGY INC.

发明人： KIEFER, Michael, C. , BARR, Philip, J.

IPC分类号： A01K67 , C07H21 , C07K14 , C07K16 , C12N5 , C12N15 , C12P21 , C12Q1 , G01N33 , A61K38 , C12R1

CPC分类号： C12N15/8509 , A01K2217/05 , A01K2227/105 , A01K2267/025 , A01K2267/03 , A61K38/00 , C07K14/4747 , C12Q1/6876 , C12Q2600/158

摘要： The present invention provides a novel family of apoptosis-modulating proteins. Nucleotide and amino acid residue sequences, derivatives thereof and methods of use thereof are also provided.

2.

发明公开
NOVEL FAS PROTEIN AND METHODS OF USE THEREOF 失效
标题翻译： Fas蛋白及使用方法

公开(公告)号：EP0729300A1

公开(公告)日：1996-09-04

申请号：EP95901253.0

申请日：1994-11-15

申请人： LXR BIOTECHNOLOGY INC.

发明人： BARR, Philip, J. , SHAPIRO, John, P. , KIEFER, Michael, C.

IPC分类号： A01K67 , A61K31 , A61K38 , A61K39 , A61K48 , A61P17 , A61P35 , C07H21 , C07K14 , C07K16 , C12N5 , C12N15 , C12P21 , G01N33

CPC分类号： A61K31/711 , A61K38/00 , C07K14/70578 , C07K14/715 , C07K16/2878 , C12N2799/026

摘要： The present invention provides a novel form of the Fas protein, DNA encoding the protein cells expressing the recombinant DNA and methods of use thereof.

3.

发明公开
A NOVEL FAMILY OF POLLEN PROTEINASES, METHODS OF USE THEREOF AND COMPOSITIONS DERIVED THEREFROM 失效
标题翻译： POLLENPROTEINASEN新系列，其使用方法和衍生组合

公开(公告)号：EP0705435A1

公开(公告)日：1996-04-10

申请号：EP94921321.0

申请日：1994-06-17

申请人： LXR BIOTECHNOLOGY INC. , UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.

发明人： TRAVIS, James , BARR, Philip, J.

IPC分类号： G01N33 , A61K36 , A61K38 , A61P37 , A61P43 , C07H21 , C12N1 , C12N9 , C12N15 , C12P21 , C12Q1 , A61K39 , C12R1

CPC分类号： C12N9/50 , A61K39/00

摘要： A novel family of proteins has been identified. The proteins are derived from allergenic pollens and exhibit serine-proteinase-like activity. The proteins have a molecular weight of about 85-95 kD as determined by sodium dodecyl sulfate polyacrylamide gel electrophoresis; and a molecular weight of about 67 kD as determined by Fast Protein Liquid Chromatography. The proteins are resistant to inhibition by α-2-macroglobulin, α-1-proteinase inhibitor, trypsin inhibitors and are sensitive to inhibition by phenyl methane sulfonyl fluoride, difluorophenol, benzamidine, antipain, leupeptin and tosyl-L-lysine chloromethyl ketone.

4.

发明公开
METHODS OF SCREENING FOR THERAPEUTIC AGENTS USING NOVEL APOPTOSIS-MODULATING PROTEINS 失效
标题翻译：一种筛选使用新的细胞凋亡调节蛋白的治疗剂

公开(公告)号：EP0821793A1

公开(公告)日：1998-02-04

申请号：EP96913062.0

申请日：1996-04-19

申请人： LXR BIOTECHNOLOGY INC.

发明人： BARR, Philip, J. , KIEFER, Michael, C.

IPC分类号： A61K38 , A61K45 , A61P31 , C07K14 , G01N33

CPC分类号： G01N33/6845 , C07K14/4747 , C07K14/82 , G01N33/68

摘要： The present invention provides methods to screen for anti-viral agents utilizing a novel family of apoptosis-modulating proteins.

5.

发明公开
COMPOSITIONS WHICH INHIBIT APOPTOSIS, METHODS OF PURIFYING THE COMPOSITIONS AND USES THEREOF 失效
标题翻译：组合物，它可以防止细胞凋亡，方法清洗这种组合物及其用途

公开(公告)号：EP0732930A1

公开(公告)日：1996-09-25

申请号：EP95903617.0

申请日：1994-11-30

申请人： LXR BIOTECHNOLOGY INC.

发明人： BATHURST, Ian, Cyril , BRADLEY, John, D. , TOMEI, L., David , BARR, Philip, J.

IPC分类号： A61K , A61K8 , A01N1 , A61K36 , A61K47 , A61P1 , A61P9 , A61P17 , A61P25 , A61P37 , A61P43 , C12N5

CPC分类号： A61K36/48 , A61K8/97 , A61K35/20 , A61Q19/08 , A61K2300/00

摘要： The present invention is directed to methods of obtaining plant-derived delipidated extracts that inhibit apoptosis, the extracts obtained, compositions containing said extracts and methods of using said compositions. The figure is a bar graph which illustrates a lower incidence of diarrhea in rats treated with methotrexate and fed a diet of compositions of the claimed invention as compared to controls.