-
1.发明公开A NOVEL FAMILY OF POLLEN PROTEINASES, METHODS OF USE THEREOF AND COMPOSITIONS DERIVED THEREFROM 失效POLLENPROTEINASEN新系列，其使用方法和衍生组合
公开(公告)号：EP0705435A1
公开(公告)日：1996-04-10
申请号：EP94921321.0
申请日：1994-06-17
发明人： TRAVIS, James , BARR, Philip, J.
IPC分类号： G01N33 , A61K36 , A61K38 , A61P37 , A61P43 , C07H21 , C12N1 , C12N9 , C12N15 , C12P21 , C12Q1 , A61K39 , C12R1
摘要： A novel family of proteins has been identified. The proteins are derived from allergenic pollens and exhibit serine-proteinase-like activity. The proteins have a molecular weight of about 85-95 kD as determined by sodium dodecyl sulfate polyacrylamide gel electrophoresis; and a molecular weight of about 67 kD as determined by Fast Protein Liquid Chromatography. The proteins are resistant to inhibition by α-2-macroglobulin, α-1-proteinase inhibitor, trypsin inhibitors and are sensitive to inhibition by phenyl methane sulfonyl fluoride, difluorophenol, benzamidine, antipain, leupeptin and tosyl-L-lysine chloromethyl ketone.
-
公开(公告)号：EP0717747A1
公开(公告)日：1996-06-26
申请号：EP94929183.0
申请日：1994-09-09
IPC分类号： C12N9
CPC分类号： C12N9/52
摘要： Provided herein is a nucleotide sequence encoding an Arg-specific gingipain named gingipain-1 isolated from Porphyromonas gingivallis, having an apparent molecular mass of 50 kDa as estimated by SDS gel electrophoresis and an apparent molecular mass of 44 kDa as estimated by gel filtration chromatography. Gingipain-1 has amidolytic and proteolytic activity for cleavage after arginine residues and has no amidolytic and/or proteolytic activity for cleavage after lysine residues. Its activity is inhibited cysteine protease group-specific inhibitors and chelating agents. It is stabilized by Calcium and stimulated by glycine-containing peptides and glycine analogues.
-
-
4.发明公开NOVEL APOPTOSIS-MODULATING PROTEINS, DNA ENCODING THE PROTEINS AND METHODS OF USE THEREOF 失效CDN凋亡调节蛋白，YOU编码中使用的DNA和方法
公开(公告)号：EP0731636A1
公开(公告)日：1996-09-18
申请号：EP95904808.0
申请日：1994-11-30
IPC分类号： A01K67 , C07H21 , C07K14 , C07K16 , C12N5 , C12N15 , C12P21 , C12Q1 , G01N33 , A61K38 , C12R1
CPC分类号： C12N15/8509 , A01K2217/05 , A01K2227/105 , A01K2267/025 , A01K2267/03 , A61K38/00 , C07K14/4747 , C12Q1/6876 , C12Q2600/158
摘要： The present invention provides a novel family of apoptosis-modulating proteins. Nucleotide and amino acid residue sequences, derivatives thereof and methods of use thereof are also provided.
-
公开(公告)号：EP0729300A1
公开(公告)日：1996-09-04
申请号：EP95901253.0
申请日：1994-11-15
IPC分类号： A01K67 , A61K31 , A61K38 , A61K39 , A61K48 , A61P17 , A61P35 , C07H21 , C07K14 , C07K16 , C12N5 , C12N15 , C12P21 , G01N33
CPC分类号： A61K31/711 , A61K38/00 , C07K14/70578 , C07K14/715 , C07K16/2878 , C12N2799/026
摘要： The present invention provides a novel form of the Fas protein, DNA encoding the protein cells expressing the recombinant DNA and methods of use thereof.
-
6.发明公开METHODS OF SCREENING FOR THERAPEUTIC AGENTS USING NOVEL APOPTOSIS-MODULATING PROTEINS 失效一种筛选使用新的细胞凋亡调节蛋白的治疗剂
公开(公告)号：EP0821793A1
公开(公告)日：1998-02-04
申请号：EP96913062.0
申请日：1996-04-19
CPC分类号： G01N33/6845 , C07K14/4747 , C07K14/82 , G01N33/68
摘要： The present invention provides methods to screen for anti-viral agents utilizing a novel family of apoptosis-modulating proteins.
-
7.发明公开COMPOSITIONS WHICH INHIBIT APOPTOSIS, METHODS OF PURIFYING THE COMPOSITIONS AND USES THEREOF 失效组合物，它可以防止细胞凋亡，方法清洗这种组合物及其用途
公开(公告)号：EP0732930A1
公开(公告)日：1996-09-25
申请号：EP95903617.0
申请日：1994-11-30
IPC分类号： A61K , A61K8 , A01N1 , A61K36 , A61K47 , A61P1 , A61P9 , A61P17 , A61P25 , A61P37 , A61P43 , C12N5
CPC分类号： A61K36/48 , A61K8/97 , A61K35/20 , A61Q19/08 , A61K2300/00
摘要： The present invention is directed to methods of obtaining plant-derived delipidated extracts that inhibit apoptosis, the extracts obtained, compositions containing said extracts and methods of using said compositions. The figure is a bar graph which illustrates a lower incidence of diarrhea in rats treated with methotrexate and fed a diet of compositions of the claimed invention as compared to controls.
-
-
-
-
-
-
搜索结果
7 条记录 (耗时 0.016 秒)
