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公开(公告)号：EP3814359A1
公开(公告)日：2021-05-05
申请号：EP19762182.4
申请日：2019-09-05
发明人： WALDMANN, Herbert , ZISCHINSKY, Gunther , NUSSBAUMER, Peter , ZIEGLER, Slava , SCHWALFENBERG, Melanie , CERRAJERIA, Javier de Ceballos , RECKZEH, Elena Sabrina , KARAGEORGIS, George
IPC分类号： C07D491/08 , A61P3/00 , A61P29/00 , A61P35/00 , A61P37/00 , A61K31/529
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公开(公告)号：EP2655379A1
公开(公告)日：2013-10-30
申请号：EP11808834.3
申请日：2011-12-22
申请人： Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. , Technische Universität Dortmund
发明人： CHRISTMANN, Mathias , RADTKE, Lea , WALDMANN, Herbert , WILLOT, Matthieu , ZIEGLER, Slava , SUN, Hongyan
IPC分类号： C07D493/08 , A61K31/35 , A61P35/00
CPC分类号： C07D493/18 , C07D493/08
摘要： The present invention relates to compounds of the general Formula (I), which show a specific activity against cancer cell lines, the use of these compounds for prophylaxis and treatment of cancer as well as to pharmaceutical compositions containing at least one compound of general formula (I).
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3.发明公开DECALINE DERIVED COMPOUNDS AS PHARMACEUTICALLY ACTIVE AGENTS 审中-公开DEKALINE DERIVATE ALS PHARMAZEUTISCH WIRKSAME MITTEL
公开(公告)号：EP1841723A1
公开(公告)日：2007-10-10
申请号：EP05824640.6
申请日：2005-12-28
申请人： Universität Dortmund , Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. , Universität Bern
IPC分类号： C07C49/733 , C07C49/743 , C07C49/747 , C07C49/513 , C07C35/36 , A61K31/122 , A61P5/00
CPC分类号： C07C35/36 , C07C49/743 , C07C49/747 , C07C49/753 , C07C69/716 , C07C69/732 , C07C205/45 , C07C215/44 , C07C217/54 , C07C2602/28
摘要： The present invention relates to compounds having a decaline scaffold, pharmaceutically acceptable salts of these compounds and pharmaceutical compositions containing at least one of these compounds togehter with pharmaceutically acceptable carrier, excipient and/or diluents. Said decalinederived compounds can be used for prophylaxsis and/or treatment of diabetes mellitus type I, diabetes mellitus type II, tuberculosis and other infectious diseases, proliferative diseases, cancer, neurodegenerative diseases, obesity, cognitive dysfunctions and metabolic syndromes.
摘要翻译： 本发明涉及具有十氢萘支架的化合物，这些化合物的药学上可接受的盐以及含有这些化合物中的至少一种以及药学上可接受的载体，赋形剂和/或稀释剂的药物组合物。 所述十氢化萘衍生化合物可用于预防和/或治疗I型糖尿病，II型糖尿病，结核病和其他感染性疾病，增殖性疾病，癌症，神经变性疾病，肥胖症，认知功能障碍和代谢综合征。
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公开(公告)号：EP3568391B1
公开(公告)日：2020-11-11
申请号：EP18702414.6
申请日：2018-01-11
发明人： WALDMANN, Herbert , MARTÍN-GAGO, Pablo Antonio , MURARKA, Sandip , KLEIN, Christian , BASTIAENS, Philippe , WITTINGHOFER, Alfred , FANSA, Eyad Kalawy
IPC分类号： C07C311/21 , C07D409/14 , C07D241/04 , C07D493/10 , C07D209/12 , C07D211/14 , C07D211/16 , C07D317/58 , C07D407/12 , C07D295/26 , C07D213/42 , C07C311/16 , C07D401/14 , A61P35/00
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公开(公告)号：EP3568391A1
公开(公告)日：2019-11-20
申请号：EP18702414.6
申请日：2018-01-11
发明人： WALDMANN, Herbert , MARTÍN-GAGO, Pablo Antonio , MURARKA, Sandip , KLEIN, Christian , BASTIAENS, Philippe , WITTINGHOFER, Alfred
IPC分类号： C07D401/14
摘要： The present invention relates to novel substituted benzene disulfonamides of formula (I), as well as pharmaceutical compositions containing at least one of these substituted benzene disulfonamides together with at least one pharmaceutically acceptable carrier, excipient and/or diluent. Said substituted benzene disulfonamides are binding to the prenyl binding pocket of PDE6´ and therefore, are useful for the prophylaxis and treatment of cancer by inhibition of the binding of PDE6´ to farnesylated Ras proteins and thereby, inhibition of oncogenic Ras signaling in cells.
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