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公开(公告)号：EP3814359A1
公开(公告)日：2021-05-05
申请号：EP19762182.4
申请日：2019-09-05
发明人： WALDMANN, Herbert , ZISCHINSKY, Gunther , NUSSBAUMER, Peter , ZIEGLER, Slava , SCHWALFENBERG, Melanie , CERRAJERIA, Javier de Ceballos , RECKZEH, Elena Sabrina , KARAGEORGIS, George
IPC分类号： C07D491/08 , A61P3/00 , A61P29/00 , A61P35/00 , A61P37/00 , A61K31/529
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公开(公告)号：EP4333822A1
公开(公告)日：2024-03-13
申请号：EP22727767.0
申请日：2022-05-02
发明人： BERGBREDE, Tim , UNGER, Anke , DI LUCREZIA, Raffaella , CHOIDAS, Axel , KLEBL, Bert , NUSSBAUMER, Peter , MENNINGER, Sascha , HABENBERGER, Peter , ZISCHINSKY, Gunther , KOCH, Uwe , SCHRÖDER, Peter , JESTRABOVÁ, Pavla , PALOVÁ-JELÍNKOVÁ, Lenka , DÁNOVÁ, Klára , FALKENBERG-GUSTAFSSON, Maria , ARABANIAN, Laleh , GUSTAFSSON, Claes , LARSSON, Nils-Göran , PALMQVIST, Lars
IPC分类号： A61K31/166 , A61K31/167 , A61K31/4184 , A61K31/437 , A61K31/4412 , A61K31/4439 , A61K31/4523 , A61K31/453 , A61K31/4709 , A61K31/496 , A61K31/502 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/5517 , A61P35/00
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3.发明公开
公开(公告)号：EP3684762A1
公开(公告)日：2020-07-29
申请号：EP18769382.5
申请日：2018-09-20
申请人： Lead Discovery Center GmbH , Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. , Sotio a.s.
发明人： DI LUCREZIA, Raffaella , BERGBREDE, Tim , NUSSBAUMER, Peter , KOCH, Uwe , KLEBL, Bert , CHOIDAS, Axel , UNGER, Anke , LARSSON, Nils-Göran , FALKENBERG-GUSTAFSSON, Maria , GUSTAFSSON, Claes M.
IPC分类号： C07D311/18 , C07D405/12 , A61K31/37 , A61P35/00
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公开(公告)号：EP2751127B1
公开(公告)日：2016-07-27
申请号：EP12751509.6
申请日：2012-08-29
发明人： FISCHER, Gunter , MALESEVIC, Miroslav , ERDMANN, Frank , KÜHLING, Jan , BUKRINSKY, Michael , CONSTANT, Stephanie , RÜHTER, Gerd , NUSSBAUMER, Peter , DINKEL, Klaus
CPC分类号： C07K7/645 , C12N9/90 , C12Y502/01008
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公开(公告)号：EP3613738A1
公开(公告)日：2020-02-26
申请号：EP18190603.3
申请日：2018-08-23
发明人： SCHULTZ-FADEMRECHT, Carsten , KLEBL, Bert , NUSSBAUMER, Peter , DEGENHART, Carsten , BAUMANN, Matthias
IPC分类号： C07D471/04
摘要： The present invention relates to certain 4-substituted 1 H -pyrrolo[2,3-b]pyridine compounds of the formula (I) and pharmaceutically acceptable salts thereof. These compounds is useful in the treatment or prevention of a disease or medical condition mediated through certain mutated forms of ErbB receptor, especially of Exon20 Her2 and EGFR mutations.
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公开(公告)号：EP2680852A1
公开(公告)日：2014-01-08
申请号：EP12706839.3
申请日：2012-03-01
IPC分类号： A61K31/53 , A61K31/5355 , C07D251/48 , C07D403/04 , C07D471/04 , C07D487/04 , C07D495/04 , C07D513/04 , A61P31/14 , A61P31/16 , A61P31/22 , A61P33/02 , A61P33/10 , A61P33/12 , A61P31/04
CPC分类号： A61K31/5377 , A61K31/53 , A61K31/5355 , A61K45/06 , C07D251/48 , C07D401/04 , C07D403/04 , C07D403/14 , C07D413/04 , C07D471/04 , C07D487/04 , C07D495/04 , C07D513/04 , A61K2300/00
摘要： The present invention relates to disubstituted triazine derivatives and/or pharmaceutically acceptable salts thereof, the use of these derivatives as pharmaceutically active agents, especially for the prophylaxis and/or treatment of infectious diseases, including opportunistic diseases, immunological diseases, autoimmune diseases, cardiovascular diseases, cell proliferative diseases, inflammation, erectile dysfunction and stroke, and pharmaceutical compositions containing at least one of said disubstituted triazine derivatives and/or pharmaceutically acceptable salts thereof. Furthermore, the present invention relates to the use of said disubstituted triazine derivatives as inhibitors for a protein kinase.
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公开(公告)号：EP4301736A1
公开(公告)日：2024-01-10
申请号：EP22797303.9
申请日：2022-09-25
发明人： KOCH, Uwe , ZISCHINSKY, Gunther , UNGER, Anke , NUSSBAUMER, Peter , KLEBL, Bert , CHOIDAS, Axel , DINKEL, Klaus , ENGEL, Julian , DEGENHART, Carsten , HUBER, Robert , NAM, Kiyean , KIM, Jaeseung , SEO, Jeongjea , LEE, Seung-Joo , JEON, Yeejin , AHN, Wongyun
IPC分类号： C07D273/00 , A61P35/00 , A61K31/33 , C07D491/08
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公开(公告)号：EP2751127A1
公开(公告)日：2014-07-09
申请号：EP12751509.6
申请日：2012-08-29
发明人： FISCHER, Gunter , MALESEVIC, Miroslav , ERDMANN, Frank , KÜHLING, Jan , BUKRINSKY, Michael , CONSTANT, Stephanie , RÜHTER, Gerd , NUSSBAUMER, Peter , DINKEL, Klaus
CPC分类号： C07K7/645 , C12N9/90 , C12Y502/01008
摘要： The present invention relates to novel cyclosporin derivatives that do not cross the cellular membrane. The compounds according to the invention are used in medicine, more particularly in the treatment/diagnosis of acute and chronic inflammatory diseases, viral infections, cancer, degenerative muscle diseases, neurodegenerative diseases and damage that is associated with calcium homeostasis impairment. The novel cyclosporin derivatives additionally have no immunosuppressive effect.
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公开(公告)号：EP4313294A1
公开(公告)日：2024-02-07
申请号：EP22733954.6
申请日：2022-06-15
发明人： ZHANG, Jianmin , ENGEL, Julian , BAUMANN, Matthias , NUSSBAUMER, Peter , KLEBL, Bert , SCHULTZ-FADEMRECHT, Carsten
IPC分类号： A61P3/00 , A61P9/00 , A61P29/00 , A61P35/00 , A61P37/02 , C07D471/04 , C07D519/00 , A61K31/437 , A61K31/5377 , A61K31/496
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10.发明公开
公开(公告)号：EP3941906A1
公开(公告)日：2022-01-26
申请号：EP20712346.4
申请日：2020-03-19
IPC分类号： C07D215/20 , C07D401/12 , C07D409/14 , C07D471/04 , A61K31/47 , A61K31/4709 , A61P35/00
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