专利检索 ap:("LegoChem Biosciences, Inc.") AND inv:"MIN, Ji, Young" 第 1 页

1.

发明公开
CONJUGATES COMPRISING SELF-IMMOLATIVE GROUPS AND METHODS RELATED THERETO 审中-公开

公开(公告)号：EP3380124A1

公开(公告)日：2018-10-03

申请号：EP16868091.6

申请日：2016-11-23

申请人： LegoChem Biosciences, Inc.

发明人： KIM, Yong Zu , OH, Yeong Soo , CHAE, Jeiwook , SONG, Ho Young , CHUNG, Chul-Woong , PARK, Yun Hee , CHOI, Hyo Jung , PARK, Kyung Eun , KIM, Hyoungrae , KIM, Jinyeong , MIN, Ji, Young , KIM, Sung, Min , LEE, Byung Soo , WOO, Dong Hyun , JUN, Ji Eun , LEE, Su In

IPC分类号： A61K47/50 , A61K47/08

CPC分类号： A61K47/6811 , A61K38/00 , A61K47/549 , A61K47/60 , A61K47/6845 , A61K47/6855 , A61K47/6867 , A61K47/6889 , Y02A50/471 , Y02A50/475

摘要： In some aspects, the invention relates to an antibody-drug conjugate, comprising an antibody; a linker; and an active agent. The antibody-drug conjugate may comprise a self- immolative group. The linker may comprise an O-substituted oxime, e.g., wherein the oxygen atom of the oxime is substituted with a group that covalently links the oxime to the active agent; and the carbon atom of the oxime is substituted with a group that covalently links the oxime to the antibody.