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1.发明授权DERIVES DE 1H-INDOLE-PYRIDINECARBOXAMIDE ET DE 1H-INDOLE-PIPERIDINECARBOXAMIDE ET LEUR UTILISATION COMME INDUCTEURS DE TYROSINE HYDROXYLASE 有权-1H-吲哚吡啶甲酰胺和1H-吲哚哌啶衍生物及其作为酪氨酸羟化酶诱导剂
公开(公告)号：EP1931341B1
公开(公告)日：2009-11-04
申请号：EP06778790.3
申请日：2006-07-06
申请人： Les Laboratoires Servier , Centre National de la Recherche Scientifique , UNIVERSITE PARIS-SUD (PARIS 11)
发明人： BRION, Jean-Daniel , BINTEIN, Fabrice , RAZET, Rodolphe , RAZON, Patrick , RENKO, Zafiarisoa, Dolor , LEVOIRIER, Eric , PUJOL, Jean-François , WEISSMANN, Dinah , LE RIDANT, Alain , HARPEY, Catherine
IPC分类号： A61K31/4439 , A61K31/454 , C07D401/12 , A61P25/00
CPC分类号： C07D401/12
摘要： The invention relates to compounds of formula (I), to their enantiomers, diastereoisomers, N-oxides, as well as to their pharmaceutically acceptable acid or base addition salts. The inventive compounds are hydroxylase tyrosine inducers.
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2.发明公开NOUVEAUX DERIVES 1H-INDOLE-PYRIDINECARBOXAMIDES ET 1H-INDOLE-PIPERIDINECARBOXAMIDE ET LEUR UTILISATION COMME INDUCTEURS DE TYROSINE HYDROXYLASE 有权-1H-吲哚吡啶甲酰胺和1H-吲哚哌啶衍生物及其作为酪氨酸羟化酶诱导剂
公开(公告)号：EP1931341A2
公开(公告)日：2008-06-18
申请号：EP06778790.3
申请日：2006-07-06
申请人： Les Laboratoires Servier , Centre National de la Recherche Scientifique , UNIVERSITE PARIS-SUD (PARIS 11)
发明人： BRION, Jean-Daniel , BINTEIN, Fabrice , RAZET, Rodolphe , RAZON, Patrick , RENKO, Zafiarisoa, Dolor , LEVOIRIER, Eric , PUJOL, Jean-François , WEISSMANN, Dinah , LE RIDANT, Alain , HARPEY, Catherine
IPC分类号： A61K31/4439 , A61K31/454 , C07D401/12 , A61P25/00
CPC分类号： C07D401/12
摘要： The invention relates to compounds of formula (I), to their enantiomers, diastereoisomers, N-oxides, as well as to their pharmaceutically acceptable acid or base addition salts. The inventive compounds are hydroxylase tyrosine inducers.
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3.发明授权NOUVEAUX DÉRIVÉS AMINOPYRROLO[1,2- A]INDOLE ET AMINOPYRIDAZINO[1,6- A]INDOLE, LEUR PROCÉDÉ DE PRÉPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT 有权NEW氨基吡咯并[1,2-A] - 吲哚和AMINOPYRIDAZINO- [1,6-A]吲哚衍生物，PROCESS FOR THEIR和药物组合物中以
公开(公告)号：EP2102204B1
公开(公告)日：2010-05-05
申请号：EP08761737.9
申请日：2008-01-04
申请人： Les Laboratoires Servier , Centre National de la Recherche Scientifique , Université de Paris-Sud
发明人： BRION, Jean-Daniel , GALTIER, Christophe , HERVET, MAUD , LE STRAT, Frédéric , MOREAU, Anne , RENKO, Zafiarisoa, Dolor , LE RIDANT, Alain , HARPEY, Catherine
IPC分类号： C07D471/04 , C07D471/14 , C07D471/16 , A61K31/5025 , A61K31/4375 , A61P25/22 , A61P25/24
CPC分类号： C07D471/14 , C07D471/04
摘要： The invention relates to compounds of the formula (I) the enantiomers, diastereoisomers, N-oxides and addition salts thereof with a pharmaceutically acceptable acid or base. The compionds of formula (I) are tyrosine hydroxylase inductors.
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4.发明公开NOUVEAUX DÉRIVÉS TRIAZABENZO[A]NAPHTHO[2,L,8-CDE]AZULÈNE, LEUR PROCÉDÉ DE PRÉPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT 审中-公开NOVEL TRIAZABENZO- [A]萘并[2,1,8-CDE]薁衍生物，PROCESS FOR THEIR和药物组合物中以
公开(公告)号：EP2102209A2
公开(公告)日：2009-09-23
申请号：EP08761736.1
申请日：2008-01-04
申请人： Les Laboratoires Servier , Centre National de la Recherche Scientifique , Université de Paris-Sud
发明人： BRION, Jean-Daniel , HERVE, Maud , MOREAU, Anne , RENKO, Zafiarisoa, Dolor , LE RIDANT, Alain , HARPEY, Catherine
IPC分类号： C07D471/22 , A61K31/551 , A61P25/00
CPC分类号： C07D471/22
摘要： The invention relates to compounds of formula (I), to their enantiomers, diastereoisomers, and N-oxides, as well as to their addition salts to a pharmaceutically acceptable acid or base. The compounds according to the invention are powerful tyrosine hydroxylase inducers.
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5.发明公开NOUVEAUX DÉRIVÉS AMINOPYRROLO[1,2- A]INDOLE ET AMINOPYRIDAZINO[1,6- A]INDOLE, LEUR PROCÉDÉ DE PRÉPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT 有权NEW氨基吡咯并[1,2-A] - 吲哚和AMINOPYRIDAZINO- [1,6-A]吲哚衍生物，PROCESS FOR THEIR和药物组合物中以
公开(公告)号：EP2102204A1
公开(公告)日：2009-09-23
申请号：EP08761737.9
申请日：2008-01-04
申请人： Les Laboratoires Servier , Centre National de la Recherche Scientifique , Université de Paris-Sud
发明人： BRION, Jean-Daniel , GALTIER, Christophe , HERVET, MAUD , LE STRAT, Frédéric , MOREAU, Anne , RENKO, Zafiarisoa, Dolor , LE RIDANT, Alain , HARPEY, Catherine
IPC分类号： C07D471/04 , C07D471/14 , C07D471/16 , A61K31/5025 , A61K31/4375 , A61P25/22 , A61P25/24
CPC分类号： C07D471/14 , C07D471/04
摘要： The invention relates to compounds of the formula (I) the enantiomers, diastereoisomers, N-oxides and addition salts thereof with a pharmaceutically acceptable acid or base. The compionds of formula (I) are tyrosine hydroxylase inductors.
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公开(公告)号：EP3328826B1
公开(公告)日：2020-02-26
申请号：EP16744734.1
申请日：2016-07-26
申请人： INSERM - Institut National de la Santé et de la Recherche Médicale , Assistance Publique-Hôpitaux de Paris , Centre National de la Recherche Scientifique (CNRS) , Université Paris-Sud
发明人： HUMBERT, Marc , COHEN-KAMINSKY, Sylvia , DUMAS, Sébastien , BRU-MERCIER, Gilles , ALAMI, Mouad , BRION, Jean-Daniel , MESSAOUDI, Samir , GALVANI, Gilles
IPC分类号： C07C211/62 , C07C211/63
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公开(公告)号：EP3922628A1
公开(公告)日：2021-12-15
申请号：EP21185886.5
申请日：2015-04-09
发明人： ALAMI, Mouad , BRION, Jean-Daniel , MESSAOUDI, Samir , PROVOT, Olivier , SOUSSI, Mohamed-Ali , BIGNON, Jérôme , DUBOIS, Joëlle , BAKALA-WDZIECZAK, Joanna
IPC分类号： C07D215/48 , C07D215/14 , C07D215/18 , A61K31/4184 , A61P37/00
摘要： La présente invention concerne des composés inhibiteurs de la polymérisation de la tubuline, leurs procédés de préparation ainsi que leurs utilisations.
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公开(公告)号：EP2566482A1
公开(公告)日：2013-03-13
申请号：EP11718104.0
申请日：2011-05-09
申请人： Institut National de la Santé et de la Recherche Médicale , Université Paris-Sud 11 , Centre National de la Recherche Scientifique (CNRS)
发明人： RAFESTIN-OBLIN, Marie-Edith , ALAMI, Mouad , LOOSFELT, Hugues , HAMZE, Abdallah , KHAN, Ali Junaid , TIKAD, Abdellatif , LOMBES, Marc , BRION, Jean-Daniel
IPC分类号： A61K31/56 , A61K31/567 , A61K31/568 , A61K31/5685 , A61K31/569 , A61K31/57 , A61K31/575 , C07J1/00 , C07J9/00 , C07J11/00 , C07J63/00 , A61P15/04 , A61P15/18 , A61P35/00
CPC分类号： C07J63/008 , A61K31/56 , A61K31/567 , A61K31/568 , A61K31/5685 , A61K31/569 , A61K31/57 , A61K31/575 , C07J1/0011 , C07J1/0022 , C07J1/0025 , C07J3/00 , C07J7/0005 , C07J7/002 , C07J7/007 , C07J9/00 , C07J11/00 , C07J21/006
摘要： The present invention relates to a compound of formula (I): for its use as progesterone receptor antagonist, in particular for its use for the prevention and/or the treatment of cancer or uterine pathologies.
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公开(公告)号：EP3468969B1
公开(公告)日：2020-08-05
申请号：EP17729140.8
申请日：2017-06-13
申请人： Institut National de la Santé et de la Recherche Médicale (INSERM) , Centre National de la Recherche Scientifique (CNRS) , Université Paris-Saclay , Assistance Publique-Hôpitaux de Paris (APHP) , Hopital Marie Lannelongue
发明人： COHEN-KAMINSKY, Sylvia , HUMBERT, Marc , DUMAS, Sébastien , BRU-MERCIER, Gilles , MESSAOUDI, Samir , BRION, Jean-Daniel , ALAMI, Mouad , GALVANI, Gilles
IPC分类号： C07D451/02 , A61P11/00
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公开(公告)号：EP3400210A2
公开(公告)日：2018-11-14
申请号：EP17701176.4
申请日：2017-01-05
IPC分类号： C07C259/06 , A61K31/16 , A61K31/165 , A61K31/403 , A61K31/404 , A61K31/44 , A61K31/47 , A61K31/517 , A61K45/06 , C07C259/10 , C07D213/81 , C07D215/14 , C07D239/74 , C07C235/38 , C07C235/64 , C07D209/42 , C07D209/86 , C07D213/65 , A61P35/00
CPC分类号： C07C259/06 , A61K45/06 , C07C235/38 , C07C235/64 , C07C259/10 , C07D209/42 , C07D209/86 , C07D213/65 , C07D213/81 , C07D215/14 , C07D239/74
摘要： The present invention relates to the design of new molecules, referred to as "multi-target" molecules, having a double pharmacophore and acting both as inhibitors of histone deacetylases (HDAC) and as inhibitors of tubulin polymerisation. The invention also describes the method for synthesising the "multi-target" molecules and their use in the treatment of cancer, a pharmaceutical composition comprising at least one "multi-target" molecule, and the use of such compositions in the treatment of cancer.
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