专利检索 ap:("Les Laboratoires Servier S.A.") AND inv:"DATTA, Debashish, Lupin Limited (Research Park)" 第 1 页

1.

发明授权
PROCESS FOR PREPARATION OF PERINDOPRIL AND SALTS THEREOF 有权
标题翻译：用于生产培哚普利

公开(公告)号：EP1603558B1

公开(公告)日：2008-05-21

申请号：EP03720846.9

申请日：2003-02-28

申请人： Les Laboratoires Servier S.A.

发明人： DATTA, Debashish, Lupin Limited (Research Park) , SINGH, Girij, Pal, Lupin Limited (Research Park) , GODBOLE, Himanshu, Madhav,Lupin Limited , SIYAN, Rajinder Singh, Lupin Limited

IPC分类号： A61K31/4045 , C07D209/42 , A61P9/12

CPC分类号： C07D209/42 , C07C227/32 , C07C227/34 , C07C229/12

摘要： A process for preparation of perindopril of formula (II) and salts thereof which is simple, safe, convenient and cost-effective. The process involves reaction of compound of formula (I), wherein X is chlorine or bromine with compound of formula (VII) wherein A signifies that the six-membered ring of the bicyclic system is either saturated or unsaturated, followed by catalytic hydrogenation to give the perindopril of formula (II).