公开(公告)号：EP1828169A2

公开(公告)日：2007-09-05

申请号：EP05853144.3

申请日：2005-12-07

申请人： Locus Pharmaceuticals, Inc.

发明人： MICHELOTTI, Enrique Luis Four Valley Square ,  SPRINGMAN, Eric Bruce Four Valley Square ,  NGUYEN, Duyan Four Valley Square ,  SHETTY, Rupa S. Four Valley Square ,  LEE, Younghee Four Valley Square ,  MOFFETT, Kristofer Kent Four Valley Square ,  LUDINGTON, Jennifer Lee Four Valley Square ,  FUJIMOTO, Ted Tsutomu Four Valley Square ,  KONTEATIS, Zenon D. Four Valley Square ,  LIU, Bin Four Valley Square ,  HOLLINGER, Frank Four Valley Square ,  DORSEY, Bruce D. Four Valley Square

IPC分类号： C07D403/02 ,  C07D403/14 ,  C07D405/02 ,  C07D405/14 ,  C07D407/02 ,  C07D407/14 ,  C07D411/02 ,  C07D411/14 ,  C07D413/02 ,  C07D413/14 ,  A61K31/381 ,  A61K31/4155 ,  A61K31/445 ,  A61P19/02 ,  A61P35/00

CPC分类号： C07D333/38 ,  C07D231/40 ,  C07D243/08 ,  C07D277/48 ,  C07D277/56 ,  C07D295/192 ,  C07D333/36 ,  C07D403/06 ,  C07D405/06 ,  C07D409/04 ,  C07D409/06 ,  C07D409/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/06 ,  C07D417/14 ,  C07D495/04

摘要： The present invention is directed to a compound having the formula (I) wherein R1, R2, G, and Q are defined herein. The compounds of the present invention are useful as inhibitors of protein kinases such as MAP Kinases, in particular p38 kinases. The present invention is also directed to compositions comprising a compound according to the above formula. The compounds and compositions described herein are useful for treating and preventing an inflammatory condition or disease. The present invention is also directed to a method of treating or preventing a protein kinase-mediated condition.