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1.发明公开METHOD FOR MANUFACTURING ISOLATABLE OXIDE MICROPARTICLES OR HYDROXIDE MICROPARTICLES 有权VERFAHREN ZUR HERSTELLUNG ISOLIERBARER OXIDMIKROPARTIKEL ODER HYDROXIDMIKROPARTIKEL
公开(公告)号：EP2610215A1
公开(公告)日：2013-07-03
申请号：EP11820039.3
申请日：2011-08-26
发明人： KURAKI Jun , ARAKI Kaeko , MAEKAWA Masaki , HONDA Daisuke , ENOMURA Masakazu
CPC分类号： C01G23/0536 , B01D9/0009 , B01F7/00775 , B01F7/00791 , B82Y30/00 , C01B13/36 , C01F5/02 , C01F5/14 , C01F5/20 , C01F17/0043 , C01G1/02 , C01G23/0532 , C01G25/02 , C01P2002/54 , C01P2004/04 , C01P2004/64
摘要： A method for producing isolatable oxide microparticles or hydroxide microparticles using an apparatus that processes a fluid between processing surfaces of processing members that are arranged opposite each other so as to be able to approach to or separate from each other and such that at least one can rotate relative to the other. Using an apparatus that processes a fluid between processing surfaces (1 and 2) of processing members (10 and 20) that are arranged opposite each other so as to be able to approach to or separate from each other and such that at least one can rotate relative to the other, at least two fluids are mixed and oxide microparticles or hydroxide microparticles are separated, said two fluids including: a fluid containing a microparticle raw material solution comprising a microparticle raw material mixed into a solvent, and a fluid containing a microparticle-separation solution. Immediately thereafter, the following are mixed to obtain isolatable oxide microparticles or hydroxide microparticles: a fluid containing the separated oxide microparticles or hydroxide microparticles; and a fluid containing a microparticle-treatment-substance-containing solution that contains a microparticle-treatment substance that adjusts the dispersibility of the separated oxide microparticles or hydroxide microparticles.
摘要翻译： 一种用于制造可分离氧化物微粒或氢氧化物微粒的方法，该方法使用处理相互相对布置的处理构件的处理表面之间的流体以便能够彼此接近或分离并使得至少一个可旋转的装置 相对于另一个。 使用在处理构件（10和20）的处理表面（1和2）之间处理流体的装置，所述处理构件（10和20）彼此相对设置，以便能够彼此接近或分离，并且使得至少一个可以旋转 所述两种流体包括：含有微粒原料溶液的流体，所述微粒原料溶液包含混入溶剂中的微粒原料和含有微粒子原料的流体， 分离液 之后，将以下混合，得到可分离的氧化物微粒或氢氧化物微粒：含有分离的氧化物微粒或氢氧化物微粒的流体; 以及含有含微粒处理物质的溶液的流体，其含有调节分离的氧化物微粒或氢氧化物微粒的分散性的微粒处理物质。
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公开(公告)号：EP2719433A1
公开(公告)日：2014-04-16
申请号：EP12797290.9
申请日：2012-05-23
发明人： ARAKI Kaeko , HONDA Daisuke , ENOMURA Masakazu
IPC分类号： B01D11/04
CPC分类号： B01D11/04 , B01D11/0461 , B01D11/0465 , B01D11/0476 , B01D11/048 , B01F7/00758 , B01F7/00775 , B01F7/00791 , B01F15/0243
摘要： The problem addressed by the present invention is providing a fluid processing method including extraction that can extract material to be extracted continuously with high efficiency. In a thin film fluid formed between at least two processing surfaces (1, 2) disposed facing eaxh other so as to be able to approach to and separate from each other such that at least one rotates relative to the other, a fluid processing that extracts at least one kind of material to be extracted in at least one kind of the extraction solvent that can extract that material to be extracted is carried out. In addition, the fluid containing at least one kind of material to be extracted and a fluid for extraction that contains the at least one kind of extraction solvent are mixed in the thin film fluid formed between the at least two processing surfaces (1, 2) disposed facing each other so as to be able to approach to and separate from each other such that at least one rotates relative to the other, and a fluid processing process that extracts the at least one kind of material to be extracted into the at least one kind of extraction solvent is carried out.
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公开(公告)号：EP4147722A1
公开(公告)日：2023-03-15
申请号：EP20934643.6
申请日：2020-11-27
发明人： ENOMURA Masakazu , ARAKI Kaeko , YOSHIZUMI Mai
IPC分类号： A61K47/34
摘要： The present application provides a microsphere in which a main agent is uniformly dispersed in a polymer matrix, wherein an average volume-based particle diameter of the microsphere is 1 µm or more and 150 µm or less, and a variation coefficient of area ratios in four regions is 0.35 or less, wherein the area ratios in four regions are calculated by (s / A) × 100 (%) wherein the four regions are prepared by preparing a cross section observation sample obtained by cutting the microsphere; observing the cross section observation sample with an electron microscope at a magnification capable of confirming the main agent in the microsphere or a higher magnification; and dividing the electron microscope observation image into four regions; and A is an area of a respective divided region, and s is a sum of cross section areas of the main agent included in the respective divided region. The microsphere of the present invention can appropriately control the initial release amount of the main agent and its release rate during a subsequent release period, and can continuously release the main agent for a predetermined period of time.
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4.发明公开SOLID SOLUTION PIGMENT NANOPARTICLES AND METHOD FOR PRODUCING SOLID SOLUTION PIGMENT NANOPARTICLES HAVING CONTROLLED SOLID SOLUTION RATIO 审中-公开在颜料纳米粒子在需要调节固体溶液的比率固溶体中固溶过程颜料纳米微粒
公开(公告)号：EP2644658A1
公开(公告)日：2013-10-02
申请号：EP11843150.1
申请日：2011-05-20
发明人： MAEKAWA Masaki , ARAKI Kaeko , OKA Hideyuki , HONDA Daisuke , ENOMURA Masakazu
CPC分类号： C07F3/06 , B01D11/0269 , B01F3/0861 , B82Y30/00 , C01P2004/64 , C01P2004/82 , C07F1/08 , C09B67/0017 , C09B67/0019 , C09B67/0026 , C09B67/0035 , C09B67/0092 , C09C1/0081 , C09C1/04 , C09C1/627
摘要： The problem addressed by the present invention is to provide; solid solution pigment nanoparticles having a homogeneous solid solution ratio; a method for producing solid solution pigment nanoparticles having a homogeneous solid solution ratio in each primary particle; and a method for controlling the solid solution ratio of solid solution pigment nanoparticles. The solid solution pigment nanoparticles are prepared by precipitating at least two types of pigment by mixing a pigment precipitation solvent and; at least one type of pigment solution characterized in that at least two types of pigment are dissolved in a solvent: or at least two types of pigment solution characterized in that at least one type of pigment is dissolved in a solvent. The solid solution pigment nanoparticles are characterized in that the solid solution ratio of the at least two types of pigment in the primary particles of the precipitated solid solution pigment nanoparticles with respect to the ratio of the at least two types of pigment in the pigment solution mixed with the pigment precipitation solvent having a precision within 25%.
摘要翻译： 由本发明所解决的问题是提供; 具有均匀固溶体比固溶体颜料纳米粒子; 用于生产具有在各初级粒子的均匀固溶体比固溶体颜料纳米粒子的方法; 以及用于控制固体溶液颜料纳米粒子的固溶体比率的方法。 固溶体颜料纳米粒子通过通过混合颜料沉淀和溶剂沉淀至少两种类型的颜料的制备 其特征在于至少一种类型的颜料溶液做了至少两种类型的颜料在溶剂中溶解：或至少两种类型的颜料溶液中为特征的那样至少一种类型的颜料在溶剂中溶解。 将固体溶液颜料纳米粒子的特征在于的确在沉淀的固体溶液颜料纳米粒子的一次粒子的至少两种类型的颜料的固体溶液比相对于所述至少两种类型的颜料中的在色素溶液混合比率 用具有25％之内的精确度的色素沉淀的溶剂。
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公开(公告)号：EP4147721A1
公开(公告)日：2023-03-15
申请号：EP20934454.8
申请日：2020-09-11
发明人： ENOMURA Masakazu , ARAKI Kaeko
IPC分类号： A61K47/34
摘要： The present application provides a microsphere comprising a lactic acid-glycolic acid copolymer (PLGA) or polylactide (PLA) as a main component, in which a biologically active substance is uniformly dispersed, wherein an average volume-based particle diameter of the microsphere is 1 µm or more and 150 µm or less, and a variation coefficient of area ratios in six regions is 0.35 or less, wherein the area ratios in six regions are calculated by (s / A) × 100 (%) wherein the six regions are prepared by preparing a cross section observation sample obtained by cutting the microsphere; observing the cross section observation sample with an electron microscope at a magnification capable of confirming the biologically active substance in the microsphere or a higher magnification; and dividing the electron microscope observation image into six regions; and A is an area of a respective divided region, and s is a sum of cross section areas of the biologically active substance included in the respective divided region. The microsphere of the present invention can appropriately control the initial release amount of the biologically active substance and its release rate during a subsequent release period, and can continuously release the biologically active substance in vivo for a predetermined period of time.
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公开(公告)号：EP2644658B1
公开(公告)日：2018-11-28
申请号：EP11843150.1
申请日：2011-05-20
发明人： MAEKAWA Masaki , ARAKI Kaeko , OKA Hideyuki , HONDA Daisuke , ENOMURA Masakazu
CPC分类号： C07F3/06 , B01D11/0269 , B01F3/0861 , B82Y30/00 , C01P2004/64 , C01P2004/82 , C07F1/08 , C09B67/0017 , C09B67/0019 , C09B67/0026 , C09B67/0035 , C09B67/0092 , C09C1/0081 , C09C1/04 , C09C1/627
摘要： The problem addressed by the present invention is to provide a high heat-resistant phthalocyanine. The phthalocyanine is separated by mixing a phthalocyanine separation solvent and a phthalocyanine solution characterized in that a phthalocyanine starting material is dissolved in a solvent. The phthalocyanine is characterized by having high heat resistance, the decomposition temperature of the separated phthalocyanine being at least 10°C higher than the decomposition temperature of the phthalocyanine starting material. Also, the phthalocyanine solution may be the result of dissolving at least two types of phthalocyanine starting material in the solvent, the separated phthalocyanine being characterized by containing a solid solvent of the at least two types of phthalocyanine starting material and by the decomposition temperature of the separated phthalocyanine being at least 10°C higher than the decomposition temperature of a mixture of at least two types of phthalocyanine separated by mixing the phthalocyanine separation solvent and each of at least two types of phthalocyanine solution resulting from dissolving each of the at least two types of phthalocyanine starting material in a solvent.
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7.发明公开METHOD FOR PRODUCING ORGANIC MATERIAL MICROPARTICLES, AND METHOD FOR MODIFYING ORGANIC MATERIAL MICROPARTICLES 审中-公开生产有机材料微粒的方法和修改有机材料微粒的方法
公开(公告)号：EP3235877A1
公开(公告)日：2017-10-25
申请号：EP15869990.0
申请日：2015-12-15
发明人： ENOMURA Masakazu , ARAKI Kaeko , HONDA Daisuke
CPC分类号： A61K9/146 , A61K31/12 , A61K31/405 , A61K31/5383 , B01J19/00 , B01J19/0093 , B01J19/1887 , B01J2219/00889 , C08J3/12 , C09B68/20
摘要： Provided are a method for producing organic material microparticles and a method for modifying organic material microparticles, whereby it becomes possible to improve the crystallinity of organic material microparticles or achieve the crystal transformation of the organic material microparticles while preventing the growth of the organic material microparticles in a solvent. A surfactant is added to a solvent that is capable of partially dissolving organic material microparticles, and then the organic material microparticles are reacted with the solvent. In this manner, it becomes possible to improve the degree of crystallization of the organic material microparticles or achieve the crystal transformation of the organic material microparticles without substantially altering the particle diameters of the organic material microparticles.
摘要翻译： 本发明提供一种有机材料微粒的制造方法以及有机材料微粒的改性方法，可以提高有机材料微粒的结晶性，或者防止有机材料微粒的生长，同时实现有机材料微粒的结晶转变 一种溶剂。 将表面活性剂添加到能够部分溶解有机材料微粒的溶剂中，然后将有机材料微粒与溶剂反应。 以这种方式，可以改善有机材料微粒的结晶度或实现有机材料微粒的晶体转变，而基本上不改变有机材料微粒的粒径。
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8.发明公开METHOD FOR PREVENTING ADHESION OF PROCESSED OBJECT USING FORCED THIN-FILM FLUID PROCESSING DEVICE 审中-公开过程，以防止粘附的已编辑点使用流体处理装置具有改善的薄膜
公开(公告)号：EP2716354A1
公开(公告)日：2014-04-09
申请号：EP12793856.1
申请日：2012-03-15
发明人： ARAKI Kaeko , MAEKAWA Masaki , HONDA Daisuke , ENOMURA Masakazu
CPC分类号： B29C33/60 , B01F7/00775 , B01F7/00791 , B01J19/1887 , C07D471/04
摘要： Provided is a method for preventing a processed material from adhering to a processing surface constituting a flow path for a fluid to be processed, in a fluid processing method for mixing a fluid to be processed in a thin film fluid formed between at least two oppositely arranged processing surfaces capable of being brought together and moved apart, at least one rotating in a relative manner with respect to the other; and for obtaining a processed material. There are used at least two types of fluids to be processed among a raw material fluid including at least one type of raw material substance, and a fluid for processing the raw material substance; the fluids to be processed are mixed in a thin film fluids formed between at least two oppositely arranged processing surfaces (1, 2) capable of being brought together and moved apart, at least one rotating in a relative manner with respect to the other; and a processed material is obtained. The raw material fluid is introduced from the middle of the processing surfaces (1, 2), whereby the raw material substance processed in the space between the processing surfaces (1, 2) is prevented from adhering to the processing surfaces (1, 2).
摘要翻译： 提供要被处理的用于附着到构成流路的流体的处理表面防止被处理材料的方法，在流体处理方法，用于混合流体被加工成至少两个相对布置之间形成的薄膜流体 能够处理用面被汇聚和移动分开，至少一个在相对于所述其他的相对方式转动; 和用于获得经处理材料。 有使用至少两种类型的流体，以原料流体包含至少一种类型的原料物质，以及用于处理所述原料物质的流体中被处理; 要处理的流体在至少两个相对设置的处理用面之间形成的薄膜流体中混合（1，2）能够被汇聚和移动分开，至少一个在相对于所述其他的相对方式转动; 和经处理的材料被获得。 原料液被从处理用面的中间引入（1，2），由此将原料物质在处理用面之间的空间处理（1，2）被附着到处理用面防治（1，2） ，
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9.发明公开
公开(公告)号：EP3939575A1
公开(公告)日：2022-01-19
申请号：EP19919052.1
申请日：2019-03-14
发明人： ENOMURA Masakazu , ARAKI Kaeko
摘要： The present application provides approximately spherical lactic acid-glycolic acid copolymer (PLGA) microparticles comprising a biologically active substance, wherein an average volume-based particle diameter of the PLGA microparticles is 1 µm or more and 150 µm or less, and a Reactive Span Factor (R.S.F.) of the PLGA microparticles is satisfied with formula (1): 0.1
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公开(公告)号：EP3467071A1
公开(公告)日：2019-04-10
申请号：EP17806177.6
申请日：2017-04-04
发明人： ENOMURA Masakazu , HONDA Daisuke , ARAKI Kaeko
摘要： The object of the present invention is to provide a coloring ultraviolet protective agent in which the average molar absorption coefficient in the wavelength range from 200 nm to 380 nm is increased, and the color characteristics in the visible region are controlled. The present invention provides a coloring ultraviolet protective agent, which is useful for shielding ultraviolet rays and coloring, wherein the coloring ultraviolet protective agent comprises M2 doped oxide particles in which oxide particles (M1Ox) comprising at least M1 being a metal element or metalloid element, are doped with at least one M2 selected from metal elements or metalloid elements other than M1, wherein x is an arbitrary positive number, wherein an average molar absorption coefficient in the wavelength range of 200 nm to 380 nm of a dispersion in which the M2 doped oxide particles are dispersed in a dispersion medium, is improved as compared with one of a dispersion in which the oxide particles (M1Ox) are dispersed in a dispersion medium, and wherein a hue or chroma of color characteristics in the visible region of the M2 doped oxide particles is controlled.
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