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公开(公告)号：EP1456600B1
公开(公告)日：2014-02-12
申请号：EP02805201.7
申请日：2002-12-18
IPC分类号： G01B9/02
CPC分类号： G01B9/02007 , G01B9/02002 , G01B9/02078 , G01B9/0209 , G01B2290/45 , G01J9/04 , G01N21/45
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2.发明公开
公开(公告)号：EP1277040A2
公开(公告)日：2003-01-22
申请号：EP01933374.9
申请日：2001-04-27
发明人： YANG, Changhuei , WAX, Adam, P. , PERELMAN, Lev, T. , DASARI, Ramachandra, R. , FELD, Michael, S.
CPC分类号： G01N21/4795 , A61B5/0059 , A61B5/0066 , G01N21/45
摘要： The present invention relates to systems and methods of field-based light scattering spectroscopy. These systems and methods provide for the diagnosis of tissue (26) by measuring the size and distribution of cellular characteristics. Field based measurements provide phase information resulting from the interaction of scatterers within the material and the incident wavefront. These measurements can be used to provide three dimensional images of tissue.
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公开(公告)号：EP1456600A1
公开(公告)日：2004-09-15
申请号：EP02805201.7
申请日：2002-12-18
IPC分类号： G01B9/02
CPC分类号： G01B9/02007 , G01B9/02002 , G01B9/02078 , G01B9/0209 , G01B2290/45 , G01J9/04 , G01N21/45
摘要： The methods of the present invention are directed at an accurate phase-based technique for measuring one or more characteristics of an object to be measured. Such a characteristic can include arbitrarily long distances, for example, preferably with sub-nanometer precision. A preferred embodiment of the present invention employs an interferometer, for example, a Michelson interferometer, with harmonically related light sources, one continuous wave (CW) and a second source having low coherence (LC). The low coherence source provides a spectral bandwidth, preferably a bandwidth of greater than 5 nm for a 1 micron (µ) wavelength, for example, although the required bandwidth can vary as a function of wavelength and application. By slightly adjusting the center wavelength of the low coherence source between scans of the object to be measured such as a target sample, the phase relationship between the heterodyne signals of the CW and low coherence light can be used to measure the separation between reflecting surfaces or interfaces with sub-nanometer precision. As this technique is completely free of 2π ambiguity, an issue that plagues most phase-based techniques, it can be used to measure arbitrarily long optical distances without loss of precision. An application of a preferred embodiment of the method of the present invention is the precision determination of the refractive index of a sample at a given wavelength of a sample with a known physical thickness. Another application of a preferred embodiment of the method of the present invention is the precision determination of a sample's physical thickness with a known refractive index. A further application of a preferred embodiment of the method of the present invention is the precision determination of the refractive index ratio at two given wavelengths.
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公开(公告)号：EP1644720A2
公开(公告)日：2006-04-12
申请号：EP04776731.4
申请日：2004-06-18
发明人： FANG-YEN, Christopher, M. , POPESCU, Gabriel , YANG, Changhuei , WAX, Adam, P. , DASARI, Ramachandra, R. , FELD, Michael, S.
IPC分类号： G01N21/45
摘要： Preferred embodiments of the present invention are directed to systems for phase measurement which address the problem of phase noise using combinations of a number of strategies including, but not limited to, common-path interferometry, phase referencing, active stabilization and differential measurement. Embodiment are directed to optical devices for imaging small biological objects with light. These embodiments can be applied to the fields of, for example, cellular physiology and neuroscience. These preferred embodiments are based on principles of phase measurements and imaging technologies. The scientific motivation for using phase measurements and imaging technologies is derived from, for example, cellular biology at the sub-micron level which can include, without limitation, imaging origins of dysplasia, cellular communication, neuronal transmission and implementation of the genetic code. The structure and dynamics of sub-cellular constituents cannot be currently studied in their native state using the existing methods and technologies including, for example, x-ray and neutron scattering. In contrast, light based techniques with nanometer resolution enable the cellular machinery to be studied in its native state. Thus, preferred embodiments of the present invention include systems based on principles of interferometry and/or phase measurements and are used to study cellular physiology. These systems include principles of low coherence interferometry (LCI) using optical interferometers to measure phase, or light scattering spectroscopy (LSS) wherein interference within the cellular components themselves is used, or in the alternative the principles of LCI and LSS can be combined to result in systems of the present invention
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公开(公告)号：EP1278454A2
公开(公告)日：2003-01-29
申请号：EP01933109.9
申请日：2001-05-04
IPC分类号： A61B5/00
CPC分类号： G01N21/4795 , A61B5/0059 , A61B5/0073
摘要： Photon migration methods are employed to image absorbing objects embedded in a turbid medium such as tissue. For improved resolution, early arriving photons are detected to provide data with image reconstruction based on optical computed tomography (CT). The CT method is generalized to take into account the distributions of photon paths. A point spread function (PSF) is expressed in terms of the Green's function for the transport equation. This PSF provides weighting functions for use in a generalized series expansion method. Measurements of turbid medium with scattering and absorption properties included coaxial transmission scans collected in two projections. Blurring associated with multiple scattering was removed and high-resolution images can be obtained.
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