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    SYSTEMS AND METHODS FOR PHASE MEASUREMENTS
    1.
    发明公开
    SYSTEMS AND METHODS FOR PHASE MEASUREMENTS 审中-公开
    系统和相位测量方法

    公开(公告)号：EP1644720A2

    公开(公告)日：2006-04-12

    申请号：EP04776731.4

    申请日：2004-06-18

    申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY

    发明人： FANG-YEN, Christopher, M. ,  POPESCU, Gabriel ,  YANG, Changhuei ,  WAX, Adam, P. ,  DASARI, Ramachandra, R. ,  FELD, Michael, S.

    IPC分类号： G01N21/45

    摘要： Preferred embodiments of the present invention are directed to systems for phase measurement which address the problem of phase noise using combinations of a number of strategies including, but not limited to, common-path interferometry, phase referencing, active stabilization and differential measurement. Embodiment are directed to optical devices for imaging small biological objects with light. These embodiments can be applied to the fields of, for example, cellular physiology and neuroscience. These preferred embodiments are based on principles of phase measurements and imaging technologies. The scientific motivation for using phase measurements and imaging technologies is derived from, for example, cellular biology at the sub-micron level which can include, without limitation, imaging origins of dysplasia, cellular communication, neuronal transmission and implementation of the genetic code. The structure and dynamics of sub-cellular constituents cannot be currently studied in their native state using the existing methods and technologies including, for example, x-ray and neutron scattering. In contrast, light based techniques with nanometer resolution enable the cellular machinery to be studied in its native state. Thus, preferred embodiments of the present invention include systems based on principles of interferometry and/or phase measurements and are used to study cellular physiology. These systems include principles of low coherence interferometry (LCI) using optical interferometers to measure phase, or light scattering spectroscopy (LSS) wherein interference within the cellular components themselves is used, or in the alternative the principles of LCI and LSS can be combined to result in systems of the present invention

    SYSTEM AND METHOD FOR HILBERT PHASE IMAGING
    3.
    发明公开
    SYSTEM AND METHOD FOR HILBERT PHASE IMAGING 有权
    HILBERT PHASE IMAGING的系统和方法

    公开(公告)号：EP1864112A2

    公开(公告)日：2007-12-12

    申请号：EP06739540.0

    申请日：2006-03-24

    申请人： THE MASSACHUSETTS INSTITUTE OF TECHNOLOGY

    发明人： POPESCU, Gabriel ,  DASARI, Ramachandra ,  FELD, Michael ,  IKEDA, Takahiro

    IPC分类号： G01N21/45

    CPC分类号： H01L27/14601 ,  G01N15/10 ,  G01N15/1475 ,  G01N21/453 ,  G01N33/49 ,  G01N2015/0073 ,  G01N2015/008 ,  G01N2015/145 ,  G01N2015/1454 ,  G01N2015/1497 ,  G06K9/00134

    摘要： Hubert phase microscopy (HPM) as an optical technique for measuring high transverse resolution quantitative phase images associated with optically transparent objects. Due to its single-shot nature, HPM is suitable for investigating rapid phenomena that take place in transparent structures such as biological cells. A preferred embodiment is used for measuring biological systems including measurements on red blood cells, while its ability to quantify dynamic processes on the millisecond scale, for example, can be illustrated with measurements on evaporating micron- size water droplets.

    摘要翻译： 休伯特相显微镜（HPM）作为测量与光学透明物体相关的高横向分辨率定量相图像的光学技术。 由于其单发性质，HPM适用于研究在生物细胞等透明结构中发生的快速现象。 一个优选的实施方案用于测量生物系统，包括红血球的测量结果，而其定量毫秒级动态过程的能力例如可以通过蒸发微米级水滴的测量来说明。