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1.发明公开
公开(公告)号：EP0801679A1
公开(公告)日：1997-10-22
申请号：EP95917195.0
申请日：1995-04-27
CPC分类号： C07K16/18 , A61K38/00 , Y10S530/809 , Y10S530/839 , Y10S530/863
摘要： Monoclonal IgM antibodies which promote central nervous system remyelination when given to a mammal afflicted with a demyelinating disease are disclosed. These antibodies show multi-organ autoreactivity, and recognize both surface and cytoplasmic determinants on glial cells.
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2.发明授权HUMAN IGM ANTIBODIES WITH THE CAPABILITY OF INDUCING REMYELINATION, AND DIAGNOSTIC AND THERAPEUTIC USES THEREOF PARTICULARLY IN THE CENTRAL NERVOUS SYSTEM 有权人IgM抗体，该抗体的能力OWN髓鞘结构的中枢神经系统改造诱导及其诊断和治疗应用
公开(公告)号：EP1294770B1
公开(公告)日：2011-12-07
申请号：EP00948498.1
申请日：2000-05-30
IPC分类号： C07K16/06 , C07K16/18 , A61K39/395 , G01N33/53 , A61P25/02 , C12N15/13 , C12N5/10 , C12N1/19 , C12N1/21 , A61K47/48 , C07K16/46 , C12N15/63 , A61K48/00
CPC分类号： C07K16/2896 , A61K35/12 , A61K2039/505 , C07K16/00 , C07K2317/21 , C07K2317/24 , C07K2319/00 , C12N5/0622
摘要： Methods are described for treating demyelinating diseases in mammals, such as multiple sclerosis in humans, and viral diseases of the central nervous system of humans and domestic animals, such as post-infectious encephalomyelitis, or prophylactically inhibiting the initiation or progression of demyelination in these disease states, using human monoclonal autoantibodies characterized by their ability to bind structures and cells within the central nervous system. In particular, the methods utilize human monoclonal antibodies selected from the group of sHIgM22 (LIM 22), sHIgM46 cbvHIgM MSI19D10, CB2bG8, AKJR4, CB2iE12, CB2iE7 and MSI 19E5, monomers thereof, active fragments thereof and isolated or synthetic human or humanized autoantibodies having the characteristics of the foregoing. Nucleic acids and DNA molecules encoding the human monoclonal antibodies, or portions thereof, are provided. The invention also extends to the preparation and use of human polyclonal and monoclonal autoantibodies, monomers thereof, active fragments, peptide derivatives and fragments, and analogs, cognates, agonists and the like corresponding materials, and their use in diagnostic and therapeutic applications. For example, the autoantibodies, monomers, fragments, haptens, and peptide equivalents, are useful in the promotion of neural regeneration and neuroprotection, and therapeutic compositions and vaccines containing peptides or antibodies are included and presented.
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3.发明授权MONOCLONAL ANTIBODIES WHICH PROMOTE CENTRAL NERVOUS SYSTEM REMYELINATION 失效MONOKLONALE防盗器DIE DIE REMYELINISIERUNG DES ZENTRALNERVENSYSTEMSFÖRDERN
公开(公告)号：EP0801679B1
公开(公告)日：2005-03-09
申请号：EP95917195.0
申请日：1995-04-27
IPC分类号： C12N15/13 , A61K39/395 , C07K16/18 , C12N5/20 , C12N5/06
CPC分类号： C07K16/18 , A61K38/00 , Y10S530/809 , Y10S530/839 , Y10S530/863
摘要： Monoclonal IgM antibodies which promote central nervous system remyelination when given to a mammal afflicted with a demyelinating disease are disclosed. These antibodies show multi-organ autoreactivity, and recognize both surface and cytoplasmic determinants on glial cells.
摘要翻译： 公开了当给予患有脱髓鞘疾病的哺乳动物时促进中枢神经系统髓鞘再生的单克隆IgM抗体。 这些抗体显示多器官自身反应性，并识别胶质细胞上的表面和细胞质决定因素。
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