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    Pharmaceutical containing episialo complex carbohydrate
    2.
    发明公开
    Pharmaceutical containing episialo complex carbohydrate 失效
    Arzneimittel enthaltend Episialo-Komplexe-Kohlenhydrate。

    公开(公告)号：EP0443518A2

    公开(公告)日：1991-08-28

    申请号：EP91102346.3

    申请日：1991-02-19

    申请人： MECT CORPORATION

    发明人： Nagai, Yoshitaka ,  Suda, Isao ,  Hino, Akihiro ,  Sugimoto, Mamoru ,  Tanaka, Makoto ,  Ito, Masayoshi ,  Ogawa, Tomoya

    IPC分类号： A61K31/70 ,  G01N33/574 ,  A61K39/00

    CPC分类号： A61K31/7004 ,  A61K31/70

    摘要： A drug for diagnosis using a serum sample, particularly a drug for diagnosis using a serum sample for the detection of cancer containing an episialo complex carbohydrate such as epiGM₃, epiGM₄ and epiGM₅, a cancer vaccine containing the episialo complex carbohydrate, a method for diagnosis using a serum sample, particularly a diagnostic method for the prevention and therapy of cancer are disclosed.

    摘要翻译： 用于使用血清样品进行诊断的药物，特别是用于使用血清样品进行诊断的药物，用于检测含有配体复合物碳水化合物如epiGM3，epiGM4和epiGM5的癌症药物，含有配体糖复合物的癌症疫苗，使用 公开了血清样品，特别是用于预防和治疗癌症的诊断方法。

    Monoclonal antibody specifically recognizing N-glycolyl type GM2, hybridoma producing the antibody and method for preparing the hybridoma
    3.
    发明公开
    Monoclonal antibody specifically recognizing N-glycolyl type GM2, hybridoma producing the antibody and method for preparing the hybridoma 失效
    单克隆抗体具有特异性的识别的N-糖基型GM2，所述抗体的杂交瘤，以及用于杂交瘤的制备方法。

    公开(公告)号：EP0369425A1

    公开(公告)日：1990-05-23

    申请号：EP89121138.5

    申请日：1989-11-15

    申请人： MECT CORPORATION

    发明人： Hino, Akihiro ,  Kannagi, Reiji ,  Suda, Isao ,  Numata, Masaaki ,  Shibayama, Shohei ,  Sugimoto, Mamoru ,  Tomita, Kenkichi ,  Ogawa, Tomoya

    IPC分类号： C12P21/08 ,  C12N5/24

    CPC分类号： C07K16/30 ,  A61K38/00

    摘要： A monoclonal antibody having specificity to N-glycolyl type GM₂ and a hybridoma producing a monoclonal antibody which has specificity to N-glycolyl type GM₂ are described. The hybridoma can be established according to a method which comprises the fusion of (A) B-­cells obtained by immunizing an animal from which thymus is removed when it is a neonate using a synthetic N-glycolyl type GM₃ as an immunogen, and (b) myeloma cells. The monoclonal antibody can be used in, for instance, ELISA and TLC immunostaining which are usually adopted for the detection of cancer-related glycolipids.

    摘要翻译： 描述了具有特异性的N-羟GM2型和杂交瘤生产其中具有特异性N-羟GM2型的单克隆抗体的单克隆抗体。 杂交瘤可以雅丁，其包含通过免疫（从哪个胸腺动物获得（A）的B细胞的融合被移除。当它是使用合成N-羟型GM3作为免疫原性新生儿的方法，和b来建立 ）骨髓瘤细胞。 的单克隆抗体可用于，例如，ELISA和免疫染色TLC其通常采用的检测与癌症相关的糖脂。