公开(公告)号：EP0260606A2

公开(公告)日：1988-03-23

申请号：EP87113263.5

申请日：1987-09-10

申请人： MECT CORPORATION ,  MITSUI TOATSU CHEMICALS, Inc.

发明人： Nagai, Yoshitaka ,  Awaya, Akira ,  Horikomi, Kazutoshi ,  Kobayashi, Hisashi ,  Mizuchi, Akira ,  Shitori, Yoshiyasu ,  Ito, Masayoshi ,  Ogawa, Tomoya

IPC分类号： A61K31/70

CPC分类号： A61K31/7004 ,  C07H15/04

摘要： A medicament composition for curing neurotic disturbance or disorder comprising a compound represented by the following formula (I) of:

摘要翻译： D：固化神经质扰动或紊乱，其包括由下式（I）表示的化合物的药物组合物

公开(公告)号：EP0348892A2

公开(公告)日：1990-01-03

申请号：EP89111675.8

申请日：1989-06-27

申请人： MECT CORPORATION ,  MITSUI TOATSU CHEMICALS, Inc.

发明人： Nagai, Yoshitaka ,  Shibayama, Shohei ,  Numata, Masaaki ,  Yoshimura, Shoji ,  Tanaka, Makoto ,  Ito, Masayoshi ,  Awaya, Akira ,  Kobayashi, Hisashi ,  Abe, Hayao ,  Ishizuka, Yusaku ,  Ogawa, Tomoya

IPC分类号： C07K15/00 ,  C07K9/00 ,  C07K7/06

CPC分类号： C07K9/005 ,  C07K9/001 ,  Y02P20/55

摘要： A sialic acid-bonded octapeptide represented by the following general formula (I):
wherein R represents a hydrogen atom or an acetyl group; and R′ represents a lower alkyl group, an aralkyl group, a hydrogen atom or an alkali metal atom, is herein desclosed. The peptide chain of the sialic acid-bonded octapeptide is constituted by 8 amino acid molecules on the C-terminus side of FTS and the compounds represented by formula (I) can be obtained by bonding sialic acid to the amino terminus of the peptide chain according to condensation. These octapeptides show excellent physiological activity comparable to FTS and a half life in blood longer than that of FTS and it is expected that the affinity of the peptide to lymphocytes is also enhanced. Thus they can effectively be used as medicines for treating the lowering and abnormality of functions of the thymus.

摘要翻译： 由以下通式（I）表示的唾液酸键合八肽：其中R表示氢原子或乙酰基; R min表示低级烷基，芳烷基，氢原子或碱金属原子。 唾液酸键合的八肽的肽链由FTS的C末端侧的8个氨基酸分子构成，通过将唾液酸键合到肽链的氨基末端，可以得到式（I）所示的化合物， 冷凝。 这些八肽显示与FTS相当的优异的生理活性和血液中的半衰期比FTS更长，并且预期肽对淋巴细胞的亲和力也增强。 因此，它们可以有效地用作治疗胸腺功能降低和异常的药物。

公开(公告)号：EP0260606A3

公开(公告)日：1989-12-13

申请号：EP87113263.5

申请日：1987-09-10

申请人： MECT CORPORATION ,  MITSUI TOATSU CHEMICALS, Inc.

发明人： Nagai, Yoshitaka ,  Awaya, Akira ,  Horikomi, Kazutoshi ,  Kobayashi, Hisashi ,  Mizuchi, Akira ,  Shitori, Yoshiyasu ,  Ito, Masayoshi ,  Ogawa, Tomoya

IPC分类号： A61K31/70

CPC分类号： A61K31/7004 ,  C07H15/04

摘要： A medicament composition for curing neurotic disturbance or disorder comprising a compound represented by the following formula (I) of:

公开(公告)号：EP0351731A3

公开(公告)日：1990-07-18

申请号：EP89112953.8

申请日：1989-07-14

申请人： MECT CORPORATION

发明人： Nagai, Yoshitaka ,  Yamamoto, Hideki ,  Takada, Kinji ,  Ito, Masayochi

IPC分类号： C12P21/08 ,  C12N5/20 ,  A61K39/39

CPC分类号： C07K16/18

摘要： A monoclonal antibody is disclosed that specifically recognizes an epitope or an antigenic determinant represented by the following formula and specifically reacts therewith:
The monoclonal antibody can be obtained by cultivating hybridoma cells which can be generated by a method comprising fusing (A) B cells or lymphocytes obtained by immunizing an animal with a substance involving the epitope or the antigenic determinant represented by the foregoing formula with (B) myeloma cells. The monoclonal antibody shows a high specificity for ganglioside GQ 1b and ganglioside GT 1a having a specific epitope and thus can detect the epitope with a high sensitivity. Therefore, the antibody can be used for the elucidation of sugar chain's roles in cell functions and for studying the development of animals. Moreover, the monoclonal antibody has various clinical applications.

公开(公告)号：EP0316882B1

公开(公告)日：1994-07-13

申请号：EP88119045.8

申请日：1988-11-15

申请人： MECT CORPORATION

发明人： Nagai, Yoshitaka ,  Yamamoto, Hideki ,  Takada, Kinji ,  Ito, Masayoshi ,  Shitori, Yoshiyasu

IPC分类号： C12N5/12 ,  C12P21/08

CPC分类号： G01N33/574 ,  G01N33/5743 ,  G01N33/57469 ,  G01N33/92 ,  Y10S424/807 ,  Y10S530/864

公开(公告)号：EP0443518A3

公开(公告)日：1992-10-28

申请号：EP91102346.3

申请日：1991-02-19

申请人： MECT CORPORATION

发明人： Nagai, Yoshitaka ,  Suda, Isao ,  Hino, Akihiro ,  Sugimoto, Mamoru ,  Tanaka, Makoto ,  Ito, Masayoshi ,  Ogawa, Tomoya

IPC分类号： A61K31/70 ,  G01N33/574 ,  A61K39/00

CPC分类号： A61K31/7004 ,  A61K31/70

摘要： A drug for diagnosis using a serum sample, particularly a drug for diagnosis using a serum sample for the detection of cancer containing an episialo complex carbohydrate such as epiGM₃, epiGM₄ and epiGM₅, a cancer vaccine containing the episialo complex carbohydrate, a method for diagnosis using a serum sample, particularly a diagnostic method for the prevention and therapy of cancer are disclosed.

公开(公告)号：EP0443518A2

公开(公告)日：1991-08-28

申请号：EP91102346.3

申请日：1991-02-19

申请人： MECT CORPORATION

发明人： Nagai, Yoshitaka ,  Suda, Isao ,  Hino, Akihiro ,  Sugimoto, Mamoru ,  Tanaka, Makoto ,  Ito, Masayoshi ,  Ogawa, Tomoya

IPC分类号： A61K31/70 ,  G01N33/574 ,  A61K39/00

CPC分类号： A61K31/7004 ,  A61K31/70

摘要： A drug for diagnosis using a serum sample, particularly a drug for diagnosis using a serum sample for the detection of cancer containing an episialo complex carbohydrate such as epiGM₃, epiGM₄ and epiGM₅, a cancer vaccine containing the episialo complex carbohydrate, a method for diagnosis using a serum sample, particularly a diagnostic method for the prevention and therapy of cancer are disclosed.

摘要翻译： 用于使用血清样品进行诊断的药物，特别是用于使用血清样品进行诊断的药物，用于检测含有配体复合物碳水化合物如epiGM3，epiGM4和epiGM5的癌症药物，含有配体糖复合物的癌症疫苗，使用 公开了血清样品，特别是用于预防和治疗癌症的诊断方法。

公开(公告)号：EP0370256A1

公开(公告)日：1990-05-30

申请号：EP89119781.6

申请日：1989-10-24

申请人： MECT CORPORATION

发明人： Nagai, Yoshitaka ,  Yamamoto, Hideki ,  Ito, Masayoshi ,  Tomita, Kenkichi

IPC分类号： C12P21/00 ,  C12N15/00 ,  C12N5/00 ,  C07K15/00

CPC分类号： C07K16/18

摘要： A monoclonal antibody exhibits specificity to sulfated glycolipids, in particular to cerebroside sulfuric acid ester. The monoclonal antibody can be obtained from a hybridoma obtained by fusing (A) an antibody-producing cell obtained by immunizing an animal with a sulfated glycolipid as an antigen, with (B) a myeloma cell. The monoclonal antibody can be used to diagnose renal diseases of animals and treat patients suffering from such diseases. Also, it can be used in the affinity chromatography for purifying antigens capable of bonding thereto.

摘要翻译： 单克隆抗体对硫酸糖脂，特别是对脑苷脂硫酸酯显示特异性。 单克隆抗体可以从（B）骨髓瘤细胞将通过免疫动物获得的抗体产生细胞与硫酸化糖脂作为抗原而获得的杂交瘤获得。 单克隆抗体可用于诊断动物的肾脏疾病并治疗患有这些疾病的患者。 此外，它可以用于亲和层析中以纯化能够结合的抗原。

公开(公告)号：EP0351731A2

公开(公告)日：1990-01-24

申请号：EP89112953.8

申请日：1989-07-14

申请人： MECT CORPORATION

发明人： Nagai, Yoshitaka ,  Yamamoto, Hideki ,  Takada, Kinji ,  Ito, Masayochi

IPC分类号： C12P21/08 ,  C12N5/20 ,  A61K39/39

CPC分类号： C07K16/18

摘要： A monoclonal antibody is disclosed that specifically recognizes an epitope or an antigenic determinant represented by the following formula and specifically reacts therewith:
The monoclonal antibody can be obtained by cultivating hybridoma cells which can be generated by a method comprising fusing (A) B cells or lymphocytes obtained by immunizing an animal with a substance involving the epitope or the antigenic determinant represented by the foregoing formula with (B) myeloma cells. The monoclonal antibody shows a high specificity for ganglioside GQ 1b and ganglioside GT 1a having a specific epitope and thus can detect the epitope with a high sensitivity. Therefore, the antibody can be used for the elucidation of sugar chain's roles in cell functions and for studying the development of animals. Moreover, the monoclonal antibody has various clinical applications.

摘要翻译： 的单克隆抗体是圆盘游离缺失确实特异性识别表位或由下式表示的具体的抗原决定簇与发生反应有：的单克隆抗体可以通过培养这可以通过包括熔融（A）B的方法来产生杂交瘤细胞获得 细胞或淋巴细胞通过与涉及所述表位或通过与（B）的骨髓瘤细胞在上述式表示的抗原决定簇的物质免疫动物获得。 单克隆抗体显示了神经节苷脂GQ1b和神经节苷脂GT1a具有特定表位，从而可以检测表位具有高灵敏度的高特异性。 因此，该抗体可用于在细胞功能糖链的角色的阐述和研究动物的发展。 更过，单克隆抗体具有不同的临床应用。

公开(公告)号：EP0316882A2

公开(公告)日：1989-05-24

申请号：EP88119045.8

申请日：1988-11-15

申请人： MECT CORPORATION

发明人： Nagai, Yoshitaka ,  Yamamoto, Hideki ,  Takada, Kinji ,  Ito, Masayoshi ,  Shitori, Yoshiyasu

IPC分类号： C12N5/12 ,  C12P21/08

CPC分类号： G01N33/574 ,  G01N33/5743 ,  G01N33/57469 ,  G01N33/92 ,  Y10S424/807 ,  Y10S530/864

摘要： A hybridoma capable of procuding a monoclonal antibody specific to a sialic acid containing glycolipid carrying N-­acetylneuraminic acid residue having alpha 2--→ 3 linkage is herein disclosed. The hybridoma can be generated by fusing (i) B cells or lymphocytes obtained by immunizing an animal with a sialic acid containing glycolipid carrying N-­acetylneuraminic acid residue having alpha 2--→ 3 linkage and (ii) myeloma cells. The monoclonal antibody produced by the hybridoma can be used for purifying gangliosides, for treating patients suffering from melanoma and for diagnosing sera.

摘要翻译： 本文公开了能够诱导具有含唾液酸的糖脂的单克隆抗体的杂交瘤，其携带具有α2 - > 3键的N-乙酰神经氨酸残基。 杂交瘤可以通过融合（i）通过用携带具有α2→3连接的N-乙酰神经氨酸残基和（ii）骨髓瘤细胞的含唾液酸的糖脂免疫动物获得的B细胞或淋巴细胞产生。 由杂交瘤产生的单克隆抗体可用于纯化神经节苷脂，用于治疗患有黑素瘤的患者和用于诊断血清。