公开(公告)号：EP1633785B1

公开(公告)日：2012-11-28

申请号：EP04809410.6

申请日：2004-05-21

申请人： Medarex, Inc.

发明人： KELER, Tibor ,  BLANSET, Diann ,  VITALE, Laura, A. ,  LOWY, Israel ,  SRINIVASAN, Mohan

IPC分类号： C07K16/12 ,  A61K39/395 ,  G01N33/53 ,  C12N15/20 ,  C12N15/13 ,  A61K47/48 ,  A61P31/04

CPC分类号： C07K16/1278 ,  A61K47/6835 ,  A61K51/1009 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/92

公开(公告)号：EP1633785A2

公开(公告)日：2006-03-15

申请号：EP04809410.6

申请日：2004-05-21

申请人： MEDAREX, INC.

发明人： KELER, Tibor ,  BLANSET, Diann ,  VITALE, Laura, A. ,  LOWY, Israel ,  SRINIVASAN, Mohan

IPC分类号： C07K16/00

CPC分类号： C07K16/1278 ,  A61K47/6835 ,  A61K51/1009 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/92

摘要： Isolated human monoclonal antibodies which bind to Anthrax protective antigen 035 disclosed. The human antibodies can be produced in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. A1so disclosed are derivatives of the human antibodies (e.g., bispecific antibodies and immunoconjugates), pharmaceutical compositions comprising the human antibodies, non-human transgenic animals and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.