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1.发明公开
公开(公告)号：EP1976883A2
公开(公告)日：2008-10-08
申请号：EP07718000.8
申请日：2007-01-17
申请人： MEDAREX, INC.
发明人： BLACK, Amelia, Nancy , PASSMORE, David, B. , SRINIVASAN, Mohan , DICKEY, Lynn, F. , COX, Kevin, M. , PEELE, Charles, G. , WANG, Ming-Bo
CPC分类号： C07K16/2878 , A61K2039/505 , C07K2317/13 , C07K2317/21 , C07K2317/41 , C07K2317/72 , C07K2317/732
摘要： The invention pertains to anti-CD30 antibodies that lack fucosyl and xylosyl residues. The antibodies of the invention exhibit increased antibody-dependent cellular cytotoxicity (ADCC) activity, including the ability to Iyse CD30-expressing cell lines that are not lysed by the fucosylated and xylosylated form of the antibodies. The invention also provides host cells that express the anti-CD30 antibodies that lack fucosyl and xylosyl residues, wherein the host cells are deficient for a fucosyltransferase and a xylosyltransferase. Methods of using the antibodies to inhibit the growth of CD30+ cells, such as tumor cells, are also provided.
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2.发明授权
公开(公告)号：EP1633785B1
公开(公告)日：2012-11-28
申请号：EP04809410.6
申请日：2004-05-21
申请人： Medarex, Inc.
CPC分类号： C07K16/1278 , A61K47/6835 , A61K51/1009 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92
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公开(公告)号：EP2097447A2
公开(公告)日：2009-09-09
申请号：EP07871479.7
申请日：2007-11-15
申请人： Medarex, Inc.
发明人： KORMAN, Alan , SELBY, Mark , THUDIUM, Kent B. , HALK, Edward , SRINIVASAN, Mohan , PASSMORE, David B.
IPC分类号： C07K16/00 , A61K39/395
CPC分类号： C07K16/2818 , A61K2039/505 , C07K2317/21 , C07K2317/92 , Y02A50/386 , Y02A50/403 , Y02A50/407 , Y02A50/41 , Y02A50/412 , Y02A50/466 , Y02A50/472 , Y02A50/48
摘要： The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to BTLA with high affinity. Nucleic acid molecules encoding the antibodies of the disclosure, expression vectors, host cells and methods for expressing the antibodies of the disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the disclosure are also provided. The disclosure also provides methods for detecting BTLA, as well as methods for treating various diseases, including cancer and infectious diseases, using anti-BTLA antibodies.
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公开(公告)号：EP1691837A2
公开(公告)日：2006-08-23
申请号：EP04813771.5
申请日：2004-12-10
申请人： MEDAREX, INC.
发明人： DESHPANDE, Shrikant , HUANG, Haichun , SRINIVASAN, Mohan , CARDARELLI, Josephine, M. , WANG, Changyu , PASSMORE, David , RANGAN, Vangipuram, S. , LANE, Thomas, E. , KEIRSTEAD, Hans, S. , LIU, Michael, T.
IPC分类号： A61K39/395 , C12N5/10 , C12N15/00 , C12N15/63 , C07H21/04
CPC分类号： C07K16/24 , A61K2039/505 , C07K14/522 , C07K2317/21 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92
摘要： The present invention provides isolated monoclonal antibodies, particularly human antibodies, that bind to IP-10 with high affinity, inhibit the binding of IP- 10 to its receptor, inhibit IP-10-induced calcium flux and inhibit IP-10-induced cell migration. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting IP-10 activity using the antibodies of the invention, including methods for treating various inflammatory and autoimmune diseases.
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公开(公告)号：EP2046834B1
公开(公告)日：2012-10-10
申请号：EP07792618.6
申请日：2007-08-10
发明人： POGUE, Sarah, L. , KORMAN, Alan J. , CARDARELLI, Josephine, M. , SRINIVASAN, Mohan , CHEN, Bingliang , BELL, Alasdair, F.
IPC分类号： C07K16/24 , A61K39/395 , A61P3/10 , A61P9/10 , A61P29/00 , A61P35/00 , A61P37/00 , A61P37/06 , A61P43/00 , C12P21/08 , C12N5/22 , C12N15/13
CPC分类号： C07K16/24 , A61K2039/505 , C07K2299/00 , C07K2317/21 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
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公开(公告)号：EP2102238A2
公开(公告)日：2009-09-23
申请号：EP07863135.5
申请日：2007-12-20
申请人： Medarex, Inc. , Pfizer, Inc.
发明人： XU, Xu , BEDIAN, Vahe , MEADDOUGH, Erika , HUANG, Haichun , YANG, Lan , TOY, Kristopher , SRINIVASAN, Mohan , BADKAR, Advait V.
CPC分类号： C07K16/2884 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/00
摘要： The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that bind to CD44, and that function to inhibit CD44. The invention also relates to heavy and light chain immunoglobulins derived from human CD44 antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human CD44 antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions or medicaments for treatment.
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7.发明公开ANTIBODIES TO BONE MORPHOGENIC PROTEINS AND RECEPTORS THEREFOR AND METHODS FOR THEIR USE 审中-公开抗体骨形态发生蛋白及受体THEREFOR和申请流程。
公开(公告)号：EP2074144A2
公开(公告)日：2009-07-01
申请号：EP07811727.2
申请日：2007-09-05
申请人： Medarex, Inc.
发明人： ZIMMERMAN, Deborah , SELBY, Mark , SRINIVASAN, Mohan , BELL, Alasdair , SINGH, Sujata , THEOLIS, Richard Jr. , LEBLANC, Heidi N. , ZENS, Kyra D. , SPROUL, Timothy William
IPC分类号： C07K16/00 , C07K16/18 , C07K16/22 , C07K16/26 , C07K16/46 , C12N15/13 , C12N15/63 , C12N15/10 , C12N15/16 , C12N15/22 , C12N15/24 , C12N15/26 , C12N15/28 , C12N1/15 , C12N1/19 , C12N1/21
CPC分类号： C07K16/2896 , A61K2039/505 , C07K16/22 , C07K2317/21 , C07K2317/34 , C07K2317/41 , C07K2317/56 , C07K2317/72 , C07K2317/732 , C07K2317/76 , C07K2317/92
摘要： The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, which specifically bind to BMP2, BMP4, BMPRlA, BMPRlB, ACTRl, and/or BMPR2 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Also provided are immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention and, optionally, one or more additional therapeutic. The invention also provides methods for treating diseases associated with abnormal bone formation and ossification mediated by BMP2, -BMP4, BMPRlA, BMPRlB, ACTRl5 and/or BMPR2.
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公开(公告)号：EP1907424A2
公开(公告)日：2008-04-09
申请号：EP06786260.7
申请日：2006-06-30
申请人： MEDAREX, INC.
发明人： KORMAN, Alan, J. , SELBY, Mark, J. , WANG, Changyu , SRINIVASAN, Mohan , PASSMORE, David, B. , HUANG, Haichun , CHEN, Haibin
IPC分类号： C07K16/28
CPC分类号： C07K16/2827 , A61K45/06 , A61K47/6817 , A61K47/6825 , A61K47/6849 , A61K2039/505 , C07K16/28 , C07K16/2803 , C07K16/2818 , C07K2317/21 , C07K2317/41 , C07K2317/56 , C07K2317/567 , C07K2317/732 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2317/77 , C07K2317/92 , Y02A50/386 , Y02A50/403 , Y02A50/407 , Y02A50/41 , Y02A50/412 , Y02A50/466
摘要： The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to PD-Ll with high affinity. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The disclosure also provides methods for detecting PD-Ll, as well as methods for treating various diseases, including cancer and infectious diseases, using anti-PD-Ll antibodies.
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9.发明公开HUMAN MONOCLONAL ANTIBODIES TO PROGRAMMED DEATH 1(PD-1) AND METHODS FOR TREATING CANCER USING ANTI-PD-1 ANTIBODIES ALONE OR IN COMBINATION WITH OTHER IMMUNOTHERAPEUTICS 审中-公开人单克隆抗体程序性细胞死亡1（PD-1），和方法仅仅考虑用于癌症治疗的抗PD-1抗体或与其他免疫治疗学组合
公开(公告)号：EP1896582A1
公开(公告)日：2008-03-12
申请号：EP06746353.9
申请日：2006-05-02
发明人： KORMAN, Alan, J. , SRINIVASAN, Mohan , WANG, Changyu , SELBY, Mark, J. , CHEN, Bing , CARDARELLI, Josephine, M.
CPC分类号： A61K39/39558 , A61K39/00 , A61K39/3955 , A61K47/6849 , A61K51/10 , A61K2039/505 , A61K2039/507 , C07K16/18 , C07K16/28 , C07K16/2803 , C07K16/2818 , C07K16/468 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PD-1 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting PD-1, as well as methods for treating various diseases, including cancer and infectious diseases, using anti-PD-1 antibodies. The present invention further provides methods for using a combination immunotherapy, such as the combination of anti-CTLA-4 and anti-PD-1 antibodies, to treat hyperproliferative disease, such as cancer. The invention also provides methods for altering adverse events related to treatment with such antibodies individually.
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公开(公告)号：EP1846449A2
公开(公告)日：2007-10-24
申请号：EP06718506.6
申请日：2006-01-12
申请人： MEDAREX, INC.
IPC分类号： C07K16/00 , A61K39/395 , C12Q1/68 , C07H21/04 , C07K17/00
CPC分类号： C07K16/283 , C07K2317/21 , C07K2317/92 , C07K2319/30
摘要： The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to IRTA-2 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting IRTA-2, as well as methods for treating various B cell malignancies, including non-Hodgkin's lymphoma.
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