公开(公告)号：EP1210374A1

公开(公告)日：2002-06-05

申请号：EP00950674.2

申请日：2000-07-26

申请人： MEDAREX, INC. ,  NorthWest Biotherapeutics, Inc.

发明人： DEO, Yashwant ,  GRAZIANO, Robert ,  HUDSON, Debra ,  TINO, William,T. ,  HOLMES, Eric, H.

IPC分类号： C07K16/30 ,  C07K16/28 ,  A01K67/027 ,  A61K39/395 ,  G01N33/574 ,  C12N5/20 ,  C07K16/46 ,  A61P35/00

CPC分类号： C12N15/8509 ,  A01K67/0278 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2217/075 ,  A01K2217/30 ,  A01K2227/105 ,  A01K2267/01 ,  A61K2039/505 ,  C07K16/283 ,  C07K16/3069 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/732 ,  C07K2317/77

摘要： Isolated human monoclonal antibodies and antigen-binding portions thereof which specifically bind to PSMA are disclosed. Also disclosed are bispecifics which include the antibodies or antibody portions. The human antibodies can be produced in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals and hybridomas which produce the human antobodies, and therapeutic and diagnostic methods for using the human antibodies.

公开(公告)号：EP1210374B1

公开(公告)日：2006-10-11

申请号：EP00950674.2

申请日：2000-07-26

申请人： MEDAREX, INC.

发明人： DEO, Yashwant ,  GRAZIANO, Robert ,  HUDSON, Debra ,  TINO, William,T. ,  HOLMES, Eric, H.

IPC分类号： C07K16/30 ,  C07K16/28 ,  A01K67/027 ,  A61K39/395 ,  G01N33/574 ,  C12N5/20 ,  C07K16/46 ,  A61P35/00

CPC分类号： C12N15/8509 ,  A01K67/0278 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2217/075 ,  A01K2217/30 ,  A01K2227/105 ,  A01K2267/01 ,  A61K2039/505 ,  C07K16/283 ,  C07K16/3069 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/732 ,  C07K2317/77

摘要： Isolated human monoclonal antibodies and antigen-binding portions thereof which specifically bind to PSMA are disclosed. Also disclosed are bispecifics which include the antibodies or antibody portions. The human antibodies can be produced in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals and hybridomas which produce the human antobodies, and therapeutic and diagnostic methods for using the human antibodies.