公开(公告)号：EP1210374A1

公开(公告)日：2002-06-05

申请号：EP00950674.2

申请日：2000-07-26

申请人： MEDAREX, INC. ,  NorthWest Biotherapeutics, Inc.

发明人： DEO, Yashwant ,  GRAZIANO, Robert ,  HUDSON, Debra ,  TINO, William,T. ,  HOLMES, Eric, H.

IPC分类号： C07K16/30 ,  C07K16/28 ,  A01K67/027 ,  A61K39/395 ,  G01N33/574 ,  C12N5/20 ,  C07K16/46 ,  A61P35/00

CPC分类号： C12N15/8509 ,  A01K67/0278 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2217/075 ,  A01K2217/30 ,  A01K2227/105 ,  A01K2267/01 ,  A61K2039/505 ,  C07K16/283 ,  C07K16/3069 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/732 ,  C07K2317/77

摘要： Isolated human monoclonal antibodies and antigen-binding portions thereof which specifically bind to PSMA are disclosed. Also disclosed are bispecifics which include the antibodies or antibody portions. The human antibodies can be produced in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals and hybridomas which produce the human antobodies, and therapeutic and diagnostic methods for using the human antibodies.

公开(公告)号：EP1519747A2

公开(公告)日：2005-04-06

申请号：EP03721280.0

申请日：2003-01-28

申请人： Medarex, Inc.

发明人： DEO, Yashwant, M. ,  GRAZIANO, Robert ,  HUDSON, Debra ,  HOLMES, Eric, H. ,  TINO, William, T. ,  BLACK, Amelia

IPC分类号： A61K39/42 ,  A61K39/395 ,  C07K14/00 ,  C07K16/00

CPC分类号： C07K16/3069 ,  A61K2039/505 ,  C07K16/28 ,  C07K16/283 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/54 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/732 ,  C07K2317/77

摘要： Isolated human monoclonal antibodies which bind to PSMA, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced in a nonhuman transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, nonhuman transgenic animals and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.

公开(公告)号：EP1210374B1

公开(公告)日：2006-10-11

申请号：EP00950674.2

申请日：2000-07-26

申请人： MEDAREX, INC.

发明人： DEO, Yashwant ,  GRAZIANO, Robert ,  HUDSON, Debra ,  TINO, William,T. ,  HOLMES, Eric, H.

IPC分类号： C07K16/30 ,  C07K16/28 ,  A01K67/027 ,  A61K39/395 ,  G01N33/574 ,  C12N5/20 ,  C07K16/46 ,  A61P35/00

CPC分类号： C12N15/8509 ,  A01K67/0278 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2217/075 ,  A01K2217/30 ,  A01K2227/105 ,  A01K2267/01 ,  A61K2039/505 ,  C07K16/283 ,  C07K16/3069 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/732 ,  C07K2317/77

摘要： Isolated human monoclonal antibodies and antigen-binding portions thereof which specifically bind to PSMA are disclosed. Also disclosed are bispecifics which include the antibodies or antibody portions. The human antibodies can be produced in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals and hybridomas which produce the human antobodies, and therapeutic and diagnostic methods for using the human antibodies.

公开(公告)号：EP1590364A2

公开(公告)日：2005-11-02

申请号：EP03799925.7

申请日：2003-12-16

申请人： MEDAREX, INC. ,  Genmab A/S

发明人： TEELING, Jessica ,  PARREN, Paul ,  BAADSGAARD, Ole, D., M., Sc. ,  HUDSON, Debra ,  PETERSEN, Jorgen

IPC分类号： C07K1/00

CPC分类号： C07K16/244 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/4241 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/92 ,  G01N33/6869

摘要： Isolated human monoclonal antibodies which bind to IL-8 (e.g., human IL-8) are disclosed. The human antibodies can be produced in a hybridoma, transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals, hybridomas, and transfectomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.

公开(公告)号：EP1370588A2

公开(公告)日：2003-12-17

申请号：EP02706236.3

申请日：2002-02-11

申请人： Medarex, Inc.

发明人： HUDSON, Debra ,  VAN DE WINKEL, Jan ,  VAN DIJK, Marcus, A.

IPC分类号： C07K16/28 ,  C12N5/20 ,  A01K67/027 ,  C07K16/46 ,  A61K47/48 ,  C07K19/00 ,  A61K39/395 ,  A61P37/00 ,  A61P31/00 ,  G01N33/577 ,  G01N33/68 ,  C12N15/79

CPC分类号： C07K16/283 ,  A01K2217/05 ,  A61K47/6879 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/77 ,  C07K2319/00 ,  G01N33/6863 ,  G01N2333/70535

摘要： Human monoclonal antibodies which bind specifically to Fc alpha receptor (CD89), including monoclonal antibodies which react specifically to Fc receptor for IgA of human effector cells are disclosed. The binding agents, e.g., antibodies are useful for targeting human effector cells (e.g.macrophages) against a target cell (e.g. a cancer cell, an infectious agent, etc.). for this purpose, bifunctional antibodies or heteroantibodies can be constructed containing the binding region derived from an anti-Fc-alpha receptor antibody and the binding region of a target-specific antibody. Targeted effector cells can specifically lyse target cells.