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公开(公告)号：EP1210372B1
公开(公告)日：2008-01-23
申请号：EP00950679.1
申请日：2000-07-25
申请人： MEDAREX, INC.
发明人： KELER, Tibor , DEO, Yashwant , VITALE, Laura
IPC分类号： C07K16/00
CPC分类号： C12N15/8509 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/30 , A01K2227/105 , A01K2267/01 , A61K39/00 , A61K2039/505 , C07K14/71 , C07K16/283 , C07K16/2863 , C07K2317/21 , C07K2317/31 , C07K2317/622 , C07K2317/732 , C07K2319/00
摘要： Isolated human monoclonal antibodies and antigen-binding portions thereof which specifically bind to HER2/neu are disclosed. Also disclosed are bi- and multispecific molecules including human monoclonal antibodies and antigen-binding portions thereof which specifically bind to HER2/neu. The human antibodies can be produced in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
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公开(公告)号：EP1210374B1
公开(公告)日：2006-10-11
申请号：EP00950674.2
申请日：2000-07-26
申请人： MEDAREX, INC.
IPC分类号： C07K16/30 , C07K16/28 , A01K67/027 , A61K39/395 , G01N33/574 , C12N5/20 , C07K16/46 , A61P35/00
CPC分类号： C12N15/8509 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/075 , A01K2217/30 , A01K2227/105 , A01K2267/01 , A61K2039/505 , C07K16/283 , C07K16/3069 , C07K2317/21 , C07K2317/31 , C07K2317/732 , C07K2317/77
摘要： Isolated human monoclonal antibodies and antigen-binding portions thereof which specifically bind to PSMA are disclosed. Also disclosed are bispecifics which include the antibodies or antibody portions. The human antibodies can be produced in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals and hybridomas which produce the human antobodies, and therapeutic and diagnostic methods for using the human antibodies.
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公开(公告)号：EP1210374A1
公开(公告)日：2002-06-05
申请号：EP00950674.2
申请日：2000-07-26
IPC分类号： C07K16/30 , C07K16/28 , A01K67/027 , A61K39/395 , G01N33/574 , C12N5/20 , C07K16/46 , A61P35/00
CPC分类号： C12N15/8509 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/075 , A01K2217/30 , A01K2227/105 , A01K2267/01 , A61K2039/505 , C07K16/283 , C07K16/3069 , C07K2317/21 , C07K2317/31 , C07K2317/732 , C07K2317/77
摘要： Isolated human monoclonal antibodies and antigen-binding portions thereof which specifically bind to PSMA are disclosed. Also disclosed are bispecifics which include the antibodies or antibody portions. The human antibodies can be produced in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals and hybridomas which produce the human antobodies, and therapeutic and diagnostic methods for using the human antibodies.
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公开(公告)号：EP1210372A2
公开(公告)日：2002-06-05
申请号：EP00950679.1
申请日：2000-07-25
申请人： MEDAREX, INC.
发明人： KELER, Tibor , DEO, Yashwant
IPC分类号： C07K16/00
CPC分类号： C12N15/8509 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/30 , A01K2227/105 , A01K2267/01 , A61K39/00 , A61K2039/505 , C07K14/71 , C07K16/283 , C07K16/2863 , C07K2317/21 , C07K2317/31 , C07K2317/622 , C07K2317/732 , C07K2319/00
摘要： Isolated human monoclonal antibodies and antigen-binding portions thereof which specifically bind to HER2/neu are disclosed. Also disclosed are bi- and multispecific molecules including human monoclonal antibodies and antigen-binding portions thereof which specifically bind to HER2/neu. The human antibodies can be produced in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
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