公开(公告)号：EP1946753A4

公开(公告)日：2009-05-13

申请号：EP06822405

申请日：2006-10-20

申请人： MEDRX CO LTD

发明人： ENDO MITSURU ,  HAMAMOTO HIDETOSHI ,  YAMASAKI KEIKO ,  MATSUMURA SUEKO

IPC分类号： A61K31/196 ,  A61K31/352 ,  A61K31/436 ,  A61K45/00 ,  A61K47/18 ,  A61P17/00 ,  A61P37/08

CPC分类号： A61K9/0014 ,  A61K9/06 ,  A61K31/196 ,  A61K31/352 ,  A61K31/436 ,  A61K47/18

摘要： Mast cell degranulation inhibitors having a carboxyl group have not been used as medicines for external application, because of their low transdermal permeatibility. If the inhibitors are administered through transdermal application, any adverse side effect on organs in the body which may be produced when administered via an oral route administration could be avoided. Further, some of the mast cell degranulation inhibitors have an extremely poor photostability. This contributes to the difficulty in the development of a medicine for external application comprising the inhibitor. The transdermal permeability and photostability of a mast cell degranulation inhibitor can be improved by using the inhibitor in the form of a salt with an organic amine. Thus, disclosed is a preparation for external application comprising a mast cell degranulation inhibitor. The mast cell degranulation inhibitor and a preparation comprising the mast cell degranulation inhibitor can be improved in photostability.

公开(公告)号：EP1716868A4

公开(公告)日：2009-07-15

申请号：EP05704361

申请日：2005-01-27

申请人： MEDRX CO LTD

发明人： HAMAMOTO HIDETOSHI ,  ISHIBASHI MASAKI ,  MATSUMURA SUEKO ,  YAMASAKI KEIKO

IPC分类号： A61K45/08 ,  A61K9/06 ,  A61K9/12 ,  A61K9/70 ,  A61K31/407 ,  A61K47/18 ,  A61P29/00

CPC分类号： A61K9/0014 ,  A61K9/7053 ,  A61K9/7076 ,  A61K31/407

摘要： An anti-inflammatory analgesic for external use containing etodolac as NSAID, which is excellent not only in skin permeability but also in the penetration into tissues present in the portions deeper than the skin and the diffusion in the tissues and which can act directly on the muscles or joint tissues with inflammation or pain and is little irritant to the skin, more specifically, an anti-inflammatory analgesic characterized by containing etodolac and a local anesthetic.

公开(公告)号：EP1782831A4

公开(公告)日：2009-12-02

申请号：EP05768591

申请日：2005-08-01

申请人： MEDRX CO LTD

发明人： ENDO MITSURU ,  YAMASAKI KEIKO ,  HAMAMOTO HIDETOSHI ,  MATSUMURA SUEKO ,  ISHIBASHI MASAKI

IPC分类号： A61K45/06 ,  A61K31/167 ,  A61K31/352

CPC分类号： A61K31/352 ,  A61K9/0014 ,  A61K31/167 ,  A61K45/06 ,  A61K47/06 ,  A61K47/10