公开(公告)号：EP1682571A4

公开(公告)日：2006-12-06

申请号：EP04789620

申请日：2004-10-27

申请人： MEDVET SCIENCE PTY LTD

发明人： GUTHRIDGE MARK ,  RAMSHAW HAYLEY ,  STOMSKI FRANK ,  FELQUER FERNANDO ,  LOPEZ ANGEL

IPC分类号： C07K2/00 ,  A61K38/00 ,  A61K38/19 ,  A61K38/20 ,  A61P35/00 ,  A61P43/00 ,  C07K7/00 ,  C07K7/04 ,  C07K7/06 ,  C07K7/08 ,  C07K14/435 ,  C07K14/71 ,  C07K14/715

CPC分类号： C07K14/435 ,  A61K38/00 ,  C07K14/715 ,  C07K14/7153

摘要： The present invention relates to a novel bidentate motif that is composed of two adjacent residues of tyrosine and serine which have been found to be involved in the binding of crucial cytoplasmic proteins which are involved in cell signalling pathways. In some cases, the cytoplasmic proteins are ubiquitous proteins involved in cell signalling pathways that may include mitogenesis, transformation and survival. The bidentate motif may have a sequence alignment N-X-X-Y- (X) 1-13-[R/K/H/Q]-[X/Psi] 2-3-S/T-X-P; Y- (X) 1-16-[R/K/H/Q]-[X/Psi] 2-3-S/T-X-P; or N-X-X-Y-[X]1-30-[R/K/Q/H]-[X]1-4-[S/T]-X-p wherein X is any residue, Y is tyrosine, S/T is serine or threonine and Y is a hydrophibic residue or an equivalent thereof. Preferably the residues are Tyr577 and Ser585 of the common ßc of the GM-CSF/IL-5/IL-3 receptor.

公开(公告)号：EP1682570A4

公开(公告)日：2006-12-06

申请号：EP04789618

申请日：2004-10-27

申请人： MEDVET SCIENCE PTY LTD

发明人： GUTHRIDGE MARK ,  RAMSHAW HAYLEY ,  STOMSKI FRANK ,  LOPEZ ANGEL

IPC分类号： C07K2/00 ,  A61K38/00 ,  A61K38/19 ,  A61K38/20 ,  A61P35/00 ,  A61P43/00 ,  C07K5/113 ,  C07K7/06 ,  C07K14/435 ,  C07K14/71 ,  C07K14/715

CPC分类号： C07K5/1021 ,  A61K38/00 ,  C07K14/435 ,  C07K14/715 ,  C07K14/7153

摘要： The present invention relates to a binding motif and methods of regulating cell function which methods target a single amino acid residue preferably a Tyr in a binding motif equivalent to a motif of the common beta chain (ßc) of the GM-CSF/IL-3/IL-5 receptor. Preferably, the cell functions affect cell survival and proliferation in cells. The methods can be used for treatments of conditions relating to cell survival and proliferation and can be used to expand progenitor cells, for instance, for transplantation purposes.

摘要翻译： 本发明涉及调节细胞功能的结合基序和方法，所述方法靶向与GM-CSF / IL-3的普通β链基序（ßc）相当的结合基序中的单个氨基酸残基，优选Tyr / IL-5受体。 优选地，细胞功能影响细胞的细胞存活和增殖。 该方法可以用于治疗与细胞存活和增殖相关的病症，并且可以用于扩增祖细胞，例如用于移植目的。