-
公开(公告)号：EP1200421B1
公开(公告)日：2008-08-27
申请号：EP00940911.1
申请日：2000-06-30
发明人： Tsuchida, Toshio , Nagai, Hazuki , Nakashima, Takashi , Yoshida, Masashi , Konuki, Kaname , Kuroda, Asako , Isshiki, Kunio , Takeuchi, Tomio
IPC分类号： C07D311/76 , C07C69/78
CPC分类号： C07D311/76 , C07C67/31 , C07C67/343 , C07C67/46 , C07C69/92 , Y02P20/55 , C07C69/88
摘要： Provided is a process for producing an isocoumarin-3-yl-acetic acid derivative, characterized by reacting a homophthalic acid derivative represented by formula (a): (wherein Rc, R2 and R are mainly protecting groups) with a malonic acid derivating represented by formula (IV): (wherein R is an organic group including a lower alkyl group; R3 is a protecting group for a carboxyl group; and X is a halogen atom or a -OM group (wherein M is alkaline metal or alkaline earth metal)). According to the above process, various isocoumarin-3-yl-acetic acid derivatives can efficiently be provided.
-
公开(公告)号：EP1200421A1
公开(公告)日：2002-05-02
申请号：EP00940911.1
申请日：2000-06-30
发明人： Tsuchida, Toshio , Nagai, Hazuki , Nakashima, Takashi , Yoshida, Masashi , Konuki, Kaname , Kuroda, Asako , Isshiki, Kunio , Takeuchi, Tomio
IPC分类号： C07D311/76 , C07C69/78
CPC分类号： C07D311/76 , C07C67/31 , C07C67/343 , C07C67/46 , C07C69/92 , Y02P20/55 , C07C69/88
摘要： Provided is a process for producing an isocoumarin-3-yl-acetic acid derivative, characterized by reacting a homophthalic acid derivative represented by formula (a): (wherein Rc, R2 and R are mainly protecting groups) with a malonic acid derivating represented by formula (IV): (wherein R is an organic group including a lower alkyl group; R3 is a protecting group for a carboxyl group; and X is a halogen atom or a -OM group (wherein M is alkaline metal or alkaline earth metal)). According to the above process, various isocoumarin-3-yl-acetic acid derivatives can efficiently be provided.
-
搜索结果
2 条记录 (耗时 0.01 秒)
