公开(公告)号：EP3023411B1

公开(公告)日：2018-12-05

申请号：EP14825779.3

申请日：2014-07-03

Applicant: Kumiai Chemical Industry Co., Ltd.

Inventor： TANI, Shinki ,  KOGA, Minekazu ,  MATSUMOTO, Izumi

IPC: C07C67/313 ,  C07C67/31 ,  C07C69/675 ,  C07C69/716

CPC classification number: C07C67/313 ,  C07C67/31 ,  C07C69/716 ,  C07C69/675

Abstract: Provided is a method for producing an industrially useful ketomalonic acid compound such as ketomalonic acid diesters, or a hydrate thereof, by a method more favorable from an economic and environmental standpoint and from a safety standpoint. The present invention relates to a method involving reacting a malonic acid compound represented by general formula (1) (in the formula, The each Rs indicate an alkyl group, a cycloalkyl group, etc.) with chlorine dioxide to produce a ketomalonic acid compound represented by the general formula (2) (in the formula, R has the same meaning as above), or a hydrate thereof.

公开(公告)号：EP3394025A1

公开(公告)日：2018-10-31

申请号：EP16825592.5

申请日：2016-12-22

Applicant: Nederlandse Organisatie voor toegepast- natuurwetenschappelijk onderzoek TNO

Inventor： CROCKATT, Marc ,  URBANUS, Jan Harm ,  KONST, Paul Mathijs

IPC: C07C67/31 ,  C07C69/94 ,  C07C303/22 ,  C07C309/32 ,  C07C309/42 ,  C07C309/44 ,  C07C309/58 ,  C07D493/08

CPC classification number: C07C67/31 ,  C07C37/50 ,  C07C51/09 ,  C07C303/22 ,  C07C309/32 ,  C07C309/42 ,  C07C309/44 ,  C07C309/58 ,  C07C69/94 ,  C07C65/105 ,  C07C39/16

Abstract: The invention relates to a method for preparing a compound comprising two phenyl groups by reacting a bisfuranic compound with a dienophile; and to such compounds.

公开(公告)号：EP1957198B1

公开(公告)日：2018-08-22

申请号：EP06808451.6

申请日：2006-11-08

Applicant: Lucite International UK Limited

Inventor： EASTHAM, Graham, Ronald ,  WAUGH, Mark ,  RICHARDS, Philip, Ian

IPC: B01J31/24 ,  C07C67/00 ,  C07C67/31 ,  C07C67/38 ,  C07C51/09

CPC classification number: C07C67/31 ,  B01J31/2414 ,  C07C51/09 ,  C07C67/38 ,  C07C59/08 ,  C07C59/01 ,  C07C69/68 ,  C07C69/675 ,  C07C69/67

Abstract: A process for the carbonylation of ethylenically unsaturated compounds including vinyl esters and a process for the production of 3-hydroxy propanoate esters or acids. The process comprises reacting said compound with carbon monoxide in the presence of a source of hydroxyl groups and of a catalyst system. The catalyst system is obtainable by combining: (a) a metal of Group 8, 9 or 10 or a compound thereof: and (b) a bidentate ligand of general formula (I): X1(X2)-Q2-A-R—B-Q1-X3(X4).

公开(公告)号：EP2467356B1

公开(公告)日：2018-07-11

申请号：EP10807647.2

申请日：2010-08-19

Applicant: DuPont Nutrition Biosciences ApS

Inventor： WIEBE, Lars ,  SCHMIDT, Thomas

IPC: C07C69/67 ,  C07C67/08 ,  C07C67/04 ,  C07C67/31 ,  C07C69/675 ,  C11C3/00 ,  C08K5/103 ,  C08K5/11

CPC classification number: C08K5/11 ,  C07C67/03 ,  C07C67/04 ,  C07C67/08 ,  C07C67/31 ,  C07C67/313 ,  C07C69/67 ,  C08K5/103 ,  C11C3/00 ,  C07C69/675

Abstract: A process for the preparation of a compound can have the formula wherein R1, R2 and R3 are independently selected from hydrogen and acyl groups, wherein at least one of R1, R2 and R3 is a branched chain long acyl group of the formula wherein n is from 9 to 21 and m is 2n, and wherein p is from 0 to 4, wherein the other of R1, R2 and R3 are selected from short acyl groups of the formula wherein q is from 0 to 4; the process comprising the steps of: (1) providing an unsaturated compound having the formula (2) if at least one of R1, R2 and R3 is hydrogen, optionally acylating the compound; and (3a) (i) hydroxylating the unsaturated long acyl group and (ii) acylating the hydroxy long acyl group, or (3b) reacting the unsaturated long acyl group with a carboxylic acid.

公开(公告)号：EP2943462B1

公开(公告)日：2018-06-27

申请号：EP14737563.8

申请日：2014-01-10

Applicant: Sirrus, Inc.

Inventor： MALOFSKY, Bernard, Miles ,  MALOFSKY, Adam, Gregg ,  SULLIVAN, Jeffrey, M. ,  KISANGA, Philip, B. ,  ANDERSON, John, Joseph ,  COCKREM, Michael Charles, Milner ,  CARLBERG, Philip, Jay

IPC: C07C67/333 ,  C07C69/593

CPC classification number: B01J19/245 ,  B01J8/067 ,  B01J29/40 ,  B01J2208/00168 ,  B01J2208/065 ,  B01J2219/00033 ,  B01J2219/0004 ,  B01J2219/00087 ,  B01J2219/00177 ,  B01J2219/24 ,  C07C67/31 ,  C07C67/327 ,  C07C67/333 ,  C07C67/56 ,  C07C69/593 ,  C08F222/14 ,  C09D4/00 ,  C09J4/00

Abstract: Method to obtain methylene malonate and related monomers following a bis(hydroxymethyl) malonate pathway. A bis(hydroxymethyl) malonate intermediary is subsequently reacted (i.e., subjected to thermolysis) to provide a methylene malonate monomer species. A source of formaldehyde (e.g., formalin) is provided in the presence of a basic catalyst (e.g., calcium hydroxide), to which a malonate (e.g., diethyl malonate) is added under suitable reaction conditions to obtain the desired intermediary (e.g., dialkyl bis(hydroxymethyl) malonate). The intermediary is reacted (i.e., subjected to thermolysis) under suitable conditions in the presence of a suitable catalyst (e.g., a zeolite) to obtain a methylene malonate monomer. In an exemplary embodiment, the thermolysis reaction includes the addition of the bis(hydroxymethyl) malonate intermediary onto a heated catalyst. The reaction product is collected and purified. The disclosed methods may be performed in a continuous operation. Discrete steps may be performed by using modular units within a plant.

公开(公告)号：EP2736327B1

公开(公告)日：2018-02-21

申请号：EP12738129.1

申请日：2012-07-23

Applicant: Clariant International Ltd

Inventor： BAUR, Peter ,  LORENZ, Klaus ,  HOFMANN, Jörg

IPC: A01N25/22 ,  C07C67/31 ,  C07C69/708 ,  A01N25/30 ,  A01N37/36

CPC classification number: A01N25/22 ,  A01N25/30 ,  A01N37/36 ,  C07C67/31 ,  C07C69/708 ,  A01N43/653 ,  A01N43/88 ,  A01N47/40

公开(公告)号：EP3281931A1

公开(公告)日：2018-02-14

申请号：EP17191895.6

申请日：2007-10-15

Applicant: Elevance Renewable Sciences, Inc.

Inventor： ABRAHAM, Timothy W. ,  KAIDO, Hiroki ,  LEE, Choon, Woo ,  PEDERSON, Richard L. ,  SCHRODI, Yann ,  TUPY, Michael John

IPC: C07C6/04 ,  C07C67/38 ,  C07C69/34 ,  C08F210/14 ,  B01J19/00 ,  C07C67/333 ,  C07C67/02

CPC classification number: C07C67/475 ,  B01J31/2265 ,  B01J31/2278 ,  B01J2231/543 ,  B01J2531/821 ,  C07C6/04 ,  C07C67/02 ,  C07C67/303 ,  C07C67/307 ,  C07C67/31 ,  C07C67/333 ,  C07C2531/22 ,  C07C2531/24 ,  C07F7/1884 ,  C07C11/02 ,  C07C69/65 ,  C07C69/734 ,  C07C69/533 ,  C07C69/593 ,  C07C69/73

Abstract: Described are methods of making organic compounds by metathesis chemistry. The methods of the invention are particularly useful for making industrially-important organic compounds beginning with starting compositions derived from renewable feedstocks, such as natural oils. The methods make use of a cross-metathesis step with an olefin compound to produce functionalized alkene intermediates having a pre-determined double bond position. Once isolated, the functionalized alkene intermediate can be self-metathesized or cross-metathesized (e.g., with a second functionalized alkene) to produce the desired organic compound or a precursor thereto. The method may be used to make bifunctional organic compounds, such as diacids, diesters, dicarboxylate salts, acid/esters, acid/amines, acid/alcohols, acid/aldehydes, acid/ketones, acid/halides, acid/nitriles, ester/amines, ester/alcohols, ester/aldehydes, ester/ketones, ester/halides, ester/nitriles, and the like.

Abstract translation: 描述了通过复分解化学制造有机化合物的方法。 本发明的方法对于制备工业上重要的有机化合物特别有用，所述有机化合物从以可再生原料如天然油衍生的起始组合物开始。 该方法利用与烯烃化合物的交叉复分解步骤来产生具有预定双键位置的官能化烯烃中间体。 一旦分离，官能化的烯烃中间体可以自身易位或交叉易位（例如用第二官能化烯烃）以产生所需的有机化合物或其前体。 该方法可用于制备双官能有机化合物，如二酸，二酯，二羧酸盐，酸/酯，酸/胺，酸/醇，酸/醛，酸/酮，酸/卤化物，酸/腈，酯/ 胺，酯/醇，酯/醛，酯/酮，酯/卤化物，酯/腈等。

公开(公告)号：EP3181545A1

公开(公告)日：2017-06-21

申请号：EP15842755

申请日：2015-09-15

Applicant: SHIONOGI & CO

Inventor： OKAMOTO KAZUYA ,  UENO TATSUHIKO ,  TOYOTA TAKASHI ,  SATOU YUUSUKE

IPC: C07C67/14 ,  C07B61/00 ,  C07C37/20 ,  C07C39/24 ,  C07C41/30 ,  C07C43/225 ,  C07C43/23 ,  C07C69/712 ,  C07C69/78

CPC classification number: C07C67/14 ,  C07B2200/13 ,  C07C37/20 ,  C07C37/68 ,  C07C41/26 ,  C07C41/30 ,  C07C67/29 ,  C07C67/31 ,  C07C69/734 ,  C07C69/736 ,  C07C69/78 ,  C07C39/373 ,  C07C43/23

Abstract: We provide a novel and useful process for preparing triphenyl-butene derivative. A process for the preparation of a compound represented by Formula (IV): wherein R 1 is hydrogen or substituted or unsubstituted alkyl, characterized by reacting a compound represented by Formula (V): with a compound represented by Formula (VI): wherein R 1 has the same meaning as defined above, in the presence of 1) a polyvalent metal chloride, 2) a reducing agent and 3) an alkali metal salt and / or a substituted or unsubstituted phenol.

Abstract translation: 我们提供了一种新颖而有用的制备三苯基丁烯衍生物的方法。 （IV）表示的化合物的制备方法：其中R 1为氢或取代或未取代的烷基，其特征在于使式（V）所示的化合物：与式（VI）所示的化合物反应：其中R 1具有与上述定义相同的含义，在1）多价金属氯化物，2）还原剂和3）碱金属盐和/或取代或未取代的苯酚存在下进行。

公开(公告)号：EP2927220A4

公开(公告)日：2016-05-25

申请号：EP13857920

申请日：2013-09-09

Applicant: KUREHA CORP

Inventor： KIKUMOTO SHIGEYUKI ,  SHIMOKAWARA TAKASHI

IPC: C07D319/08 ,  C07C45/65 ,  C07C49/747

CPC classification number: C07D405/06 ,  C07C45/64 ,  C07C45/65 ,  C07C49/493 ,  C07C59/215 ,  C07C67/31 ,  C07D249/08 ,  C07D319/08 ,  C07C49/747

公开(公告)号：EP2964384A1

公开(公告)日：2016-01-13

申请号：EP14713774.9

申请日：2014-03-05

Applicant: DexLeChem GmbH

Inventor： JOST, Sonja

IPC: B01J31/24 ,  C07C29/145

CPC classification number: C07C29/143 ,  B01J31/2409 ,  B01J31/2457 ,  B01J2231/643 ,  B01J2531/0266 ,  B01J2531/821 ,  B01J2531/90 ,  B01J2531/96 ,  C07B2200/07 ,  C07C29/145 ,  C07C67/31 ,  C07F15/0046 ,  C07C31/205 ,  C07C31/20 ,  C07C69/675

Abstract: The invention relates to a method for converting a precatalyst complex to an active catalyst complex, wherein the precatalyst complex and the active catalyst complex comprise a ruthenium atom and an optically active ligand that is insoluble in water, and the active catalyst complex furthermore comprises a monohydride and a water molecule. The method comprises the steps of providing water as an activation solvent system with a pH value equal or below 2, and solving said precatalyst complex, an acid, and hydrogen therein. The invention further relates to a method for manufacturing a catalyst composition, a method for hydrogenating a substrate molecule and a reaction mixture.

Abstract translation: 本发明涉及将预催化剂配合物转化为活性催化剂配合物的方法，其中预催化剂配合物和活性催化剂配合物包含钌原子和不溶于水的光学活性配体，并且活性催化剂配合物还包含单氢化物 和一个水分子。 该方法包括提供水作为pH值等于或低于2的活化溶剂体系，并在其中溶解所述预催化剂配合物，酸和氢的步骤。 本发明进一步涉及制造催化剂组合物的方法，氢化底物分子和反应混合物的方法。