公开(公告)号：EP0839034B1

公开(公告)日：2004-06-02

申请号：EP96924537.2

申请日：1996-07-15

申请人： MERCK & CO., INC. ,  Merck Frosst Canada & Co.

发明人： KARGMAN, Stacia ,  EVANS, Jilly ,  SIMON, Thomas, J.

IPC分类号： A61K31/40 ,  A61K31/19 ,  A61K31/195 ,  A61K31/54 ,  A61K31/12 ,  A61K31/34 ,  A61P35/00

CPC分类号： A61K31/603 ,  A61K31/00 ,  A61K31/12 ,  A61K31/18 ,  A61K31/19 ,  A61K31/192 ,  A61K31/195 ,  A61K31/196 ,  A61K31/34 ,  A61K31/365 ,  A61K31/405 ,  A61K31/407 ,  A61K31/54 ,  A61K31/5415 ,  A61K31/616

摘要： This invention is directed to a method of retarding or preventing the transformation of a colonic adenoma to a colonic adenocarcinoma comprising the administration to a patient with FAP or a patient with one or more of said adenomas a non-toxic therapeutically effective amount of NSAID, said amount effective to inhibit the PGHS-2 in said adenoma. The preferred method comprises the administration of a specific PGHS-2 inhibiting agent as defined herein.

公开(公告)号：EP0839034A1

公开(公告)日：1998-05-06

申请号：EP96924537.0

申请日：1996-07-15

申请人： MERCK & CO., INC. ,  MERCK FROSST CANADA INC.

发明人： KARGMAN, Stacia ,  EVANS, Jilly ,  SIMON, Thomas, J.

IPC分类号： A61K31

CPC分类号： A61K31/603 ,  A61K31/00 ,  A61K31/12 ,  A61K31/18 ,  A61K31/19 ,  A61K31/192 ,  A61K31/195 ,  A61K31/196 ,  A61K31/34 ,  A61K31/365 ,  A61K31/405 ,  A61K31/407 ,  A61K31/54 ,  A61K31/5415 ,  A61K31/616

摘要： This invention is directed to a method of retarding or preventing the transformation of a colonic adenoma to a colonic adenocarcinoma comprising the administration to a patient with FAP or a patient with one or more of said adenomas a non-toxic therapeutically effective amount of NSAID, said amount effective to inhibit the PGHS-2 in said adenoma. The preferred method comprises the administration of a specific PGHS-2 inhibiting agent as defined herein.

公开(公告)号：EP1727533A1

公开(公告)日：2006-12-06

申请号：EP05723530.1

申请日：2005-02-24

申请人： Merck & Co., Inc. ,  Merck Frosst Canada Ltd.

发明人： EVANS, Jilly ,  FORD-HUTCHINSON, Anthony ,  HUTCHINSON, John, H. ,  YOUNG, Robert

IPC分类号： A61K31/16

CPC分类号： A61K31/00 ,  A61K31/196 ,  A61K31/47

摘要： The instant invention provides a method for treating and/or reducing the risk for atherosclerosis, pulmonary fibrosis and stroke, comprising administering an effective amount of a cysteinyl leukotriene 2 receptor antagonist, including a selective cysteinyl leukotriene 2 receptor antagonist and a dual cysteinyl leukotriene 1 receptor and cysteinyl leukotriene 2 receptor antagonist to a patient in need of such treatment.

公开(公告)号：EP1536684A2

公开(公告)日：2005-06-08

申请号：EP03793338.9

申请日：2003-08-22

申请人： Merck & Co., Inc.

发明人： EVANS, Jilly ,  HUTCHINSON, John, H.

IPC分类号： A01N43/42 ,  C07D215/04 ,  C07D401/00

CPC分类号： A61K45/06 ,  A61K31/4709 ,  A61K2300/00

摘要： The instant invention provides a method for treating and/or reducing the risk for atherosclerosis comprising administering an effective amount of a FLAP inhibitor alone or in combination with another anti-atherosclerotic agent to a patient in need of such treatment.