专利检索 ap:("MERCK & CO., INC." OR "Merck Frosst Canada & Co." OR "Univerity of Texas Health Science Center at San Antonio" OR "National Institutes of Health" OR "MERCK SHARP & DOHME LTD.") AND inv:"NG, Gordon, Yiu, Kon" 第 1 页

1.

发明公开
NOVEL GABA B? RECEPTOR DNA SEQUENCES 审中-公开
标题翻译：新的DNA序列替代GABA B受体CODE。

公开(公告)号：EP1053253A1

公开(公告)日：2000-11-22

申请号：EP99905705.2

申请日：1999-02-03

申请人： MERCK & CO., INC. , Merck Frosst Canada & Co. , Univerity of Texas Health Science Center at San Antonio , National Institutes of Health , MERCK SHARP & DOHME LTD.

发明人： LIU, Quingyun , McDONALD, Terrence , BONNERT, Timothy P. , NG, Gordon, Yiu, Kon , KOLAKOWSKI, Lee, F., Jr. , CLARK, Janet , BONNER, Tom, I.

IPC分类号： C07K14/705 , C12N5/10 , C12N15/09 , C12N15/11 , C12N15/12 , C12N15/62 , G01N33/566

CPC分类号： C07K14/70571 , C07K2319/00

摘要： DNA encoding a novel human GABAB receptor subunit, HG20, as well as the protein encoded by the DNA, is provided. Also provided is DNA encoding a novel murine GABAB receptor subunit, GABABR1a, as well as the protein encoded by the DNA. Heterodimers of HG20 protein and GABABR1a protein that form a functional GABAB receptor are disclosed. Methods of identifying agonists and antagonists of the GABAB receptor are also provided.