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1.发明公开
公开(公告)号：EP1615882A2
公开(公告)日：2006-01-18
申请号：EP04750027.7
申请日：2004-04-09
申请人： Merck & Co., Inc.
IPC分类号： C07D207/16
CPC分类号： C07D401/04 , C07D207/16 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04
摘要： A novel process is provided for the preparation of pyrrolidine carboxylic acids, and the useful intermediates obtained therein. These compounds are intermediates for the synthesis of melanocortin-4 receptor (MC-4R), which are useful for the treatment of disorders such as obesity, diabetes, male sexual dysfunction, and female sexual dysfunction.
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公开(公告)号：EP0858460A1
公开(公告)日：1998-08-19
申请号：EP96937014.0
申请日：1996-10-28
申请人： MERCK & CO., INC.
CPC分类号： C07D405/12 , C07D205/08 , C07D317/54 , C07D317/58
摘要： The present invention relates to the process for the preparation of the substituted azetidinone having formula (I) comprising a convergent synthesis.
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公开(公告)号：EP0722454B1
公开(公告)日：1999-05-12
申请号：EP94931307.6
申请日：1994-10-04
申请人： Merck & Co., Inc.
IPC分类号： C07H19/01 , A01N43/90 , C07D493/22 , A61K31/365
CPC分类号： C07D493/22
摘要： There is disclosed a novel form of avermectin compounds wherein the avermectin compounds are crystallized as alcohol solvates to greatly enhance stability of the avermectin drug during long-term storage. The avermectin compounds have utility as highly potent antiparasitic, insecticidal, and anthelmintic agents and compositions for that use are also disclosed.
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公开(公告)号：EP0722454A1
公开(公告)日：1996-07-24
申请号：EP94931307.0
申请日：1994-10-04
申请人： MERCK & CO. INC.
CPC分类号： C07D493/22
摘要： There is disclosed a novel form of avermectin compounds wherein the avermectin compounds are crystallized as alcohol solvates to greatly enhance stability of the avermectin drug during long-term storage. The avermectin compounds have utility as highly potent antiparasitic, insecticidal, and anthelmintic agents and compositions for that use are also disclosed.
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