公开(公告)号：EP0526936A3

公开(公告)日：1993-05-05

申请号：EP92202300.7

申请日：1992-07-25

申请人： MERCK & CO. INC.

发明人： Meinz, Maria Sandrino ,  Pelaez, Fernando ,  Omstead, Mary Nallin ,  Milligan, James A. ,  Diez, Maria Teresa ,  Onishi, Janet C. ,  Bergstrom, James D. ,  Jenkins, Rosalind F. ,  Harris, Guy H. ,  Jones, E. Tracy Turner ,  Huang, Leeyuan ,  Kong, Yu Lin ,  Lingham, Russell B. ,  Zink, Deborah

IPC分类号： C07C235/76 ,  C07D209/20 ,  A61K31/195 ,  A61K31/405 ,  C07C211/10 ,  C07C215/12 ,  C07C279/14

CPC分类号： C12P13/04 ,  C07C235/76 ,  C07D209/20

摘要： This invention relates to compounds of structural formula (I): which are squalene synthase inhibitors and thus useful as cholesterol lowering agents, and antifungal agents. These compounds are also inhibitors of farnesyl protein transferase and farnesylation of the oncogene protein Ras and thus useful in treating cancer. This invention also relates to a process for obtaining compounds of structural formula (I).

公开(公告)号：EP0526936A2

公开(公告)日：1993-02-10

申请号：EP92202300.7

申请日：1992-07-25

申请人： MERCK & CO. INC.

发明人： Meinz, Maria Sandrino ,  Pelaez, Fernando ,  Omstead, Mary Nallin ,  Milligan, James A. ,  Diez, Maria Teresa ,  Onishi, Janet C. ,  Bergstrom, James D. ,  Jenkins, Rosalind F. ,  Harris, Guy H. ,  Jones, E. Tracy Turner ,  Huang, Leeyuan ,  Kong, Yu Lin ,  Lingham, Russell B. ,  Zink, Deborah

IPC分类号： C07C235/76 ,  C07D209/20 ,  A61K31/195 ,  A61K31/405 ,  C07C211/10 ,  C07C215/12 ,  C07C279/14

CPC分类号： C12P13/04 ,  C07C235/76 ,  C07D209/20

摘要： This invention relates to compounds of structural formula (I):
which are squalene synthase inhibitors and thus useful as cholesterol lowering agents, and antifungal agents. These compounds are also inhibitors of farnesyl protein transferase and farnesylation of the oncogene protein Ras and thus useful in treating cancer. This invention also relates to a process for obtaining compounds of structural formula (I).

摘要翻译： 本发明涉及结构式（I）的化合物：作为角鲨烯合成酶抑制剂的，因此可用作胆固醇降低剂和抗真菌剂。 这些化合物也是法呢基蛋白转移酶的抑制剂和致癌基因蛋白Ras的法呢基化，因此可用于治疗癌症。 本发明还涉及获得结构式（I）化合物的方法。