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1.发明公开Novel culture of exserohilum rostratum and processes therefrom 失效Kultur von Exserohilum Rostratum和Anwendungsverfahren。
公开(公告)号：EP0524671A1
公开(公告)日：1993-01-27
申请号：EP92201809.8
申请日：1992-06-19
申请人： MERCK & CO. INC.
CPC分类号： C12R1/645 , C12P17/181
摘要： This invention relates to a strain of Exserohilum rostratum isolated from tree bark and useful in a fermentation process to form compounds of formula (I):
摘要翻译： 本发明涉及从树皮中分离出的切丝霉菌株，可用于形成式（I）化合物的发酵过程：
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2.发明公开Novel anthelmintic milbemycin analogs of novel microorganisms 失效Anthelmintische Milbemycin-Analoge aus neuen Mikroorganismen。
公开(公告)号：EP0511881A1
公开(公告)日：1992-11-04
申请号：EP92303999.4
申请日：1992-05-01
申请人： MERCK & CO. INC.
发明人： Goegelman, Robert T. , Sykes, Ruth S. , Munguira, Elvira , Helms, Gregory L. , Diez Matas, Maria Teresa , Turner Jones, E. Tracy , Kong, Yu Lin , Liesch, Jerrold M.
IPC分类号： C07H19/01 , C07D493/22 , C12P17/18 , A01N43/90 , A61K31/70
摘要： There is disclosed a series of macrolides of formulae I-IV isolated from the fermentation broth of microorganisms identified as MA-6825, MA-6864 and MA-6865. The structure of the novel compounds isolated from the microorganisms is presented based upon analytical studies. The compounds are highly potent antiparasitic, insecticidal, and anthelmintic agents and are related to the class of macrolides known as milbemycins. Compositions for such uses are also disclosed.
摘要翻译： 公开了从被鉴定为MA-6825，MA-6864和MA-6865的微生物发酵液中分离出的一系列式I-IV的大环内酯类。 基于分析研究提出了从微生物分离的新化合物的结构。 这些化合物是非常有效的抗寄生虫，杀虫剂和驱肠虫剂，并且与称为米尔倍霉素的大环内酯类有关。 还公开了用于此类用途的组合物。
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公开(公告)号：EP0526936A3
公开(公告)日：1993-05-05
申请号：EP92202300.7
申请日：1992-07-25
申请人： MERCK & CO. INC.
发明人： Meinz, Maria Sandrino , Pelaez, Fernando , Omstead, Mary Nallin , Milligan, James A. , Diez, Maria Teresa , Onishi, Janet C. , Bergstrom, James D. , Jenkins, Rosalind F. , Harris, Guy H. , Jones, E. Tracy Turner , Huang, Leeyuan , Kong, Yu Lin , Lingham, Russell B. , Zink, Deborah
IPC分类号： C07C235/76 , C07D209/20 , A61K31/195 , A61K31/405 , C07C211/10 , C07C215/12 , C07C279/14
CPC分类号： C12P13/04 , C07C235/76 , C07D209/20
摘要： This invention relates to compounds of structural formula (I): which are squalene synthase inhibitors and thus useful as cholesterol lowering agents, and antifungal agents. These compounds are also inhibitors of farnesyl protein transferase and farnesylation of the oncogene protein Ras and thus useful in treating cancer. This invention also relates to a process for obtaining compounds of structural formula (I).
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公开(公告)号：EP0526936A2
公开(公告)日：1993-02-10
申请号：EP92202300.7
申请日：1992-07-25
申请人： MERCK & CO. INC.
发明人： Meinz, Maria Sandrino , Pelaez, Fernando , Omstead, Mary Nallin , Milligan, James A. , Diez, Maria Teresa , Onishi, Janet C. , Bergstrom, James D. , Jenkins, Rosalind F. , Harris, Guy H. , Jones, E. Tracy Turner , Huang, Leeyuan , Kong, Yu Lin , Lingham, Russell B. , Zink, Deborah
IPC分类号： C07C235/76 , C07D209/20 , A61K31/195 , A61K31/405 , C07C211/10 , C07C215/12 , C07C279/14
CPC分类号： C12P13/04 , C07C235/76 , C07D209/20
摘要： This invention relates to compounds of structural formula (I):
which are squalene synthase inhibitors and thus useful as cholesterol lowering agents, and antifungal agents. These compounds are also inhibitors of farnesyl protein transferase and farnesylation of the oncogene protein Ras and thus useful in treating cancer. This invention also relates to a process for obtaining compounds of structural formula (I).摘要翻译： 本发明涉及结构式（I）的化合物：作为角鲨烯合成酶抑制剂的
，因此可用作胆固醇降低剂和抗真菌剂。 这些化合物也是法呢基蛋白转移酶的抑制剂和致癌基因蛋白Ras的法呢基化，因此可用于治疗癌症。 本发明还涉及获得结构式（I）化合物的方法。 -
5.发明公开
公开(公告)号：EP0525846A1
公开(公告)日：1993-02-03
申请号：EP92201829.6
申请日：1992-06-20
申请人： MERCK & CO. INC.
CPC分类号： C12R1/645 , C12P17/181
摘要： This invention relates to strains of Sporormiella intermedia that are isolated from the dung of herbivorous animals from xeric environments and are useful in a fermentation process to form compounds of formula (I):
摘要翻译： 本发明涉及从干燥环境的食草动物的粪便中分离的中间孢霉菌株，并且可用于形成式（I）化合物的发酵过程：
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