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    Inhibitors of HIV protease
    4.
    发明公开
    Inhibitors of HIV protease 失效
    HIV蛋白酶Hemmstoffe。

    公开(公告)号：EP0480624A1

    公开(公告)日：1992-04-15

    申请号：EP91309028.8

    申请日：1991-10-02

    申请人： MERCK & CO. INC.

    发明人： Treiber, Lazslo R. ,  Lingham, Russell B. ,  Arison, Byron H. ,  Colwell, Lawrence F., Jr. ,  Dezeny, Georgette ,  Kohl, Nancy E.

    IPC分类号： C07D295/088 ,  C12P17/14

    CPC分类号： C07D295/088 ,  C12P17/14

    摘要： A novel dipeptide isostere is the biotransformed product after incubation with a culture of Streptomyces . It inhibits HIV protease, and is useful in the prevention or treatment of infection by DIV and the treatment of AIDS, either as a compound, pharmaceutically acceptable salt, pharmaceutical composition ingredient, whether or not as a prodrug or as a combination with other antivirals, anti-infectives, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventinp or treating infection by DIV are also described.

    摘要翻译： 新型二肽等排物是与Streptomyces培养物孵育后的生物转化产物。 它可以抑制HIV蛋白酶，并且可用作预防或治疗DIV的感染和治疗AIDS，无论作为化合物，药学上可接受的盐，药物组合物成分，无论是作为前药还是作为与其它抗病毒药物的组合， 抗感染药，免疫调节剂，抗生素或疫苗。 还描述了治疗AIDS的方法和预防或治疗DIV感染的方法。

    Inhibitors of HIV protease
    6.
    发明公开
    Inhibitors of HIV protease 失效
    HIV蛋白酶Hemmstoffe。

    公开(公告)号：EP0480711A1

    公开(公告)日：1992-04-15

    申请号：EP91309292.0

    申请日：1991-10-09

    申请人： MERCK & CO. INC.

    发明人： Treiber, Laszlo R. ,  Dezeny, Georgette ,  Colwell, Lawrence F. ,  Lingham, Russell B. ,  Arison, Byron H. ,  Thompson, Wayne J. ,  Balani, Suresh Kumar

    IPC分类号： C07C271/22 ,  C12P13/02

    CPC分类号： C07C271/22 ,  C12P13/02

    摘要： A dipeptide isostere is the biotransformed product after incubation with a culture of Streptomyces . It inhibits HIV protease, and is useful in the prevention or treatment of infection by HIV and the treatment of AIDS, either as a compound, pharmaceutically acceptable salt, pharmaceutical composition ingredient, whether or not as a prodrug or as a combination with other antivirals, anti-infectives, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.

    摘要翻译： 二肽等体积是与Streptomyces培养物孵育后的生物转化产物。 它抑制HIV蛋白酶，并且可用作预防或治疗HIV感染和治疗艾滋病，作为化合物，药学上可接受的盐，药物组合物成分，无论作为前药或与其它抗病毒药物的组合， 抗感染药，免疫调节剂，抗生素或疫苗。 还描述了治疗AIDS的方法和预防或治疗HIV感染的方法。