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公开(公告)号：EP0450761A1
公开(公告)日：1991-10-09
申请号：EP91301685.3
申请日：1991-02-28
申请人： MERCK & CO. INC.
IPC分类号： C07D221/20 , C07D209/96 , C07D491/10 , C07D471/10 , C07D487/10 , C07D401/06 , C07D401/12 , C07D401/04 , A61K31/445 , A61K31/40
CPC分类号： C07D221/20 , C07D209/96 , C07D405/12 , C07D471/10 , C07D487/10 , C07D491/10
摘要： Disclosed are spirocyclic compounds of the formula:
The compounds of formula I are oxytocin antagonists useful in the treatment of preterm labor and dysmenorrhea, and for the stoppage of labor preporatory to Caesarian delivery. Also disclosed are pharmaceutical compositions containing these compounds as well as methods for preparing the compounds.摘要翻译： 公开了下式的螺环化合物：式I化合物是可用于治疗早产和痛经的催产素拮抗剂，以及用于停止对Caesarian分娩的预防性劳动。 还公开了含有这些化合物的药物组合物以及制备化合物的方法。
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2.发明授权Amide-substituted derivatives of spiroindanylcamphorsulfonyl oxytocin antagonists 失效通过酰胺基团取代Spiroindanylcamphorsulfonylderivate催产素拮抗剂
公开(公告)号：EP0533244B1
公开(公告)日：1997-12-17
申请号：EP92202724.8
申请日：1992-09-08
申请人： Merck & Co., Inc.
发明人： Bock, Mark G. , Gilbert, Kevin , Evans, Ben E. , Hobbs, Doug W. , Freidinger, Roger M. , Hoffman, James B. , Lundell, George F. , Pettibone, Douglas J.
IPC分类号： C07D401/12 , A61K31/445 , C07D401/14 , C07D221/20
CPC分类号： C07D221/20 , C07D401/12 , C07D401/14
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公开(公告)号：EP0444945A3
公开(公告)日：1992-05-13
申请号：EP91301684.6
申请日：1991-02-28
申请人： MERCK & CO. INC.
IPC分类号： A61K31/40 , A61K31/445 , A61K31/395 , A61K31/495 , A61K31/535 , A61K31/55
CPC分类号： A61K31/445 , A61K31/40 , A61K31/44 , A61K31/535 , A61K31/55
摘要： Disclosed are spirocyclic compounds of the formula:
The compounds of formula I are oxytocin antagonists useful in the treatment of preterm labor and dysmenorrhea, and for the stoppage of labor preporatory to Caesarian delivery. Also disclosed are pharmaceutical compositions containing these compounds as well as methods for preparing the compounds.-
公开(公告)号：EP0617001A1
公开(公告)日：1994-09-28
申请号：EP94301728.5
申请日：1994-03-10
申请人： MERCK & CO. INC.
发明人： Greenlee, William J. , Walsh, Thomas F. , Pettibone, Douglas J. , Tata, James R. , Rivero, Ralph A. , Williams, David L. , Bagley, Scott W. , Dhanoa, Daljit S. , Chakravarty, Prasun K. , Fitch, Kenneth J. , Broten, Theodore P. , Kevin, Nancy Jo
CPC分类号： C07D257/04 , C07C59/70 , C07C65/24 , C07C311/51 , C07D317/60 , C07D317/64 , C07D319/18 , C07D405/12
摘要： Phenoxyphenylacetic acids and derivatives of the general structural formula I
have endothelin antagonist activity and are useful in treating cardiovascular disorders, such as hypertension, postischemic renal failure, vasospasm, cerebral and cardiac ischemia, myocardial infarction, endotoxic shock, benign prostatic hyperplasia, inflammatory diseases including Raynaud's disease and asthma.摘要翻译： 苯氧基苯基乙酸和一般结构式I
的衍生物具有内皮素拮抗剂活性，可用于治疗心血管疾病，如高血压，缺血性肾衰竭，血管痉挛，脑和心脏缺血，心肌梗塞，内毒素性休克，良性前列腺增生， 炎症性疾病包括雷诺氏病和哮喘。 -
公开(公告)号：EP0256847B1
公开(公告)日：1991-11-21
申请号：EP87307132.8
申请日：1987-08-12
申请人： Merck & Co., Inc.
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公开(公告)号：EP0327744A1
公开(公告)日：1989-08-16
申请号：EP88301199.1
申请日：1988-02-12
申请人： Merck & Co., Inc.
发明人： Goetz, Michael A. , Schwartz, Cheryl D. , Koupal, Lawrence R. , Liesch, Jerrold M. , Hensens, Otto D. , Freidinger, Roger , Anderson, Paul S. , Pettibone, Douglas J. , Woodruff, Boyd H.
摘要： Cyclic peptides are produced by the controlled aerobic fermentation of Streptomyces silvensis , ATCC No. 53525 or ATCC No. 53526. These compounds are antagonists of oxytocin and are useful in the treatment of preterm labor and vasopressin and are thus useful in the treatment and prevention of disease states wherein vasopressin may be involved, for example congestive heart failure, hypertension, edema and hyponatremia.
摘要翻译： 循环肽是通过对链霉菌（Streptomyces silvensis），ATCC No.55325或ATCC No.55326的受控好氧发酵产生的。这些化合物是催产素的拮抗剂，可用于治疗早产和加压素，因此可用于治疗和预防 可能涉及血管加压素的疾病状态，例如充血性心力衰竭，高血压，水肿和低钠血症。
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7.发明公开Use of spirocyclic compounds as oxytocin antagonists 失效Verwendung von spirozyklischen Verbindungen als Oxytocinantagonisten。
公开(公告)号：EP0444945A2
公开(公告)日：1991-09-04
申请号：EP91301684.6
申请日：1991-02-28
申请人： MERCK & CO. INC.
IPC分类号： A61K31/40 , A61K31/445 , A61K31/395 , A61K31/495 , A61K31/535 , A61K31/55
CPC分类号： A61K31/445 , A61K31/40 , A61K31/44 , A61K31/535 , A61K31/55
摘要： Disclosed are spirocyclic compounds of the formula:
The compounds of formula I are oxytocin antagonists useful in the treatment of preterm labor and dysmenorrhea, and for the stoppage of labor preporatory to Caesarian delivery. Also disclosed are pharmaceutical compositions containing these compounds as well as methods for preparing the compounds.摘要翻译： 公开了下式的螺环化合物：式I化合物是可用于治疗早产和痛经的催产素拮抗剂，以及用于停止对Caesarian分娩的预防性劳动。 还公开了含有这些化合物的药物组合物以及制备化合物的方法。
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公开(公告)号：EP0256847A3
公开(公告)日：1989-01-04
申请号：EP87307132.8
申请日：1987-08-12
申请人： Merck & Co., Inc.
发明人： Goetz, Michael A. , Schwartz, Cheryl D. , Koupal, Lawrence R. , Liesch, Jerrold M. , Hensens, Otto D. , Freidinger, Roger , Anderson, Paul S. , Pettibone, Douglas J. , Woodruff, Boyd H.
摘要： Cyclic peptides having the formula: are produced by the controlled aerobic fermentation of Streptomyces silvensis , ATCC No. 53525 or ATCC No. 53526. These compounds are antagonists of oxytocin and are useful in the treatment of preterm labor and vasopressin and are thus useful in the treatment and prevention of disease states wherein vasopressin may be involved, for example congestive heart failure, hypertension, edema and hyponatremia.
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公开(公告)号：EP0256847A2
公开(公告)日：1988-02-24
申请号：EP87307132.8
申请日：1987-08-12
申请人： Merck & Co., Inc.
发明人： Goetz, Michael A. , Schwartz, Cheryl D. , Koupal, Lawrence R. , Liesch, Jerrold M. , Hensens, Otto D. , Freidinger, Roger , Anderson, Paul S. , Pettibone, Douglas J. , Woodruff, Boyd H.
摘要： Cyclic peptides having the formula:
are produced by the controlled aerobic fermentation of Streptomyces silvensis , ATCC No. 53525 or ATCC No. 53526. These compounds are antagonists of oxytocin and are useful in the treatment of preterm labor and vasopressin and are thus useful in the treatment and prevention of disease states wherein vasopressin may be involved, for example congestive heart failure, hypertension, edema and hyponatremia.摘要翻译： 具有下式的环状肽：
是通过对链霉菌（Streptomyces silvensis），ATCC No.55325或ATCC No.55326的受控好氧发酵产生的。这些化合物是催产素的拮抗剂，可用于治疗早产和血管加压素 可用于治疗和预防其中可能涉及血管加压素的疾病状态，例如充血性心力衰竭，高血压，水肿和低钠血症。 -
公开(公告)号：EP0617001B1
公开(公告)日：2000-01-26
申请号：EP94301728.5
申请日：1994-03-10
申请人： Merck & Co., Inc.
发明人： Greenlee, William J. , Walsh, Thomas F. , Pettibone, Douglas J. , Tata, James R. , Rivero, Ralph A. , Williams, David L. , Bagley, Scott W. , Dhanoa, Daljit S. , Chakravarty, Prasun K. , Fitch, Kenneth J. , Broten, Theodore P. , Kevin, Nancy Jo
IPC分类号： C07D317/60 , C07D319/18 , C07C59/70 , A61K31/19 , C07C65/24
CPC分类号： C07D257/04 , C07C59/70 , C07C65/24 , C07C311/51 , C07D317/60 , C07D317/64 , C07D319/18 , C07D405/12
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