公开(公告)号：EP1319026A1

公开(公告)日：2003-06-18

申请号：EP01985259.9

申请日：2001-09-13

申请人： MERCK PATENT GmbH ,  Brace GmbH

发明人： DEPPE, Holger ,  WURZIGER, Hanns ,  SCHOBER, Andreas ,  BRANDAU, Egbert ,  BRANDAU, Thorsten ,  DALDROP, Esther

IPC分类号： C08F2/00

CPC分类号： C08F2/00 ,  Y10T428/2984 ,  Y10T428/2989

摘要： The invention relates to microspheres with a narrow distribution of particle size and a uniform spherical shape, consisting of a partially or completely cross-linked polymer material. The invention also relates to a method for producing said microspheres and to the use thereof.

公开(公告)号：EP1277058A1

公开(公告)日：2003-01-22

申请号：EP01927898.5

申请日：2001-04-09

申请人： MERCK PATENT GmbH

发明人： DEPPE, Holger ,  WURZIGER, Hanns ,  GROSS, Alexander ,  TOMANDL, Dirk ,  SCHOBER, Andreas

IPC分类号： G01N35/10

CPC分类号： G01N35/109 ,  G01N35/0099 ,  G01N2035/00079

摘要： Troublesome evaporative effects occur in a solution decanted in microchambers when chemical substances are pipetted into individual microchambers in an array (4) thereof. In order to prevent such undesirable evaporative effects, the inventive pipette device for automatic pipetting of chemical substances is provided with at least one holder (3) receiving a microchamber array and the moveably arranged head of the pipette (11) is embodied in such a way that it is secured to a plate (7) with the aid of a holding device which follows the movements of the pipette head (11) during the pipetting process. The plate (7) forms an enclosed gas chamber (14) above the microchamber array (4) in conjunction with a frame (5) which surrounds the microchamber array (4) in a tight manner. The pipette head juts out into the gas chamber via an appropriate opening (13) in the plate (7).

公开(公告)号：EP1318869A1

公开(公告)日：2003-06-18

申请号：EP01962965.8

申请日：2001-08-23

申请人： Merck Patent GmbH ,  INSTITUT FÜR PHYSIKALISCHE HOCHTECHNOLOGIE E.V.

发明人： DEPPE, Holger ,  DIEFENBACH, Beate ,  WILLEMS, Andreas ,  WURZIGER, Hanns ,  GROSS, Alexander ,  SCHLINGLOFF, Gregor ,  SCHOBER, Andreas ,  TOMANDL, Dirk

IPC分类号： B01L3/00 ,  B01L7/00

CPC分类号： B01L7/00 ,  B01L3/50851 ,  B01L3/50853 ,  B01L2200/0689 ,  B01L2200/142 ,  B01L2300/0829 ,  B01L2300/10

摘要： A device for carrying out the parallel incubation of solutions comprises a holding frame (1) inside of which one or more titer plates (2) can be placed. Each titer plate (2) is separately closed by a cover plate (4), which can be pressed thereon, resulting in the prevention of unwanted evaporation effects and transport phenomena. Seals (5) are placed between the cover plate (4) and the holding frame (1). Continuous recesses in the holding frame (1) are located underneath the titer plates (2) and are occluded by a common one-piece bottom plate (7) having punch-like protrusions (6). Devices for regulating temperature can be arranged both inside the cover plate (4), the holding frame (1) as well as inside the one-piece bottom plate (7). The holding frame (1) comprises channel-like recesses for accommodating liquid solvent.

公开(公告)号：EP1286760A1

公开(公告)日：2003-03-05

申请号：EP01931660.3

申请日：2001-04-27

申请人： MERCK PATENT GmbH

发明人： DIEFENBACH, Beate ,  DEPPE, Holger ,  WURZIGER, Hanns ,  GROSS, Alexander ,  SCHLINGLOFF, Gregor ,  SCHOBER, Andreas ,  TOMANDL, Dirk

IPC分类号： B01J19/00

CPC分类号： B01L3/50853 ,  B01J19/0046 ,  B01J2219/00286 ,  B01J2219/00317 ,  B01J2219/00333 ,  B01J2219/00585 ,  B01L3/50857 ,  B01L2300/0819 ,  C40B60/14

摘要： The invention relates to a device used in parallel microsynthesis. Microcompartments that are open on both sides are disposed in a flat arrangement in a microcompartment matrix (4) and are hermetically closed by pressure exerted on both sides by plungers (6) that are covered by a sealing film (11). A layer, produced from elastic material (9) and disposed between the plunger (6) and the sealing film (11), ensures that a continuous pressure is exerted on all microcompartments of the microcompartment matrix (4) that is loosely retained by a frame structure (1). Elevations (2) that project in both directions vertically to the plane of the microcompartment matrix (4) prevent the deformable thin layer from elastic material (9) from escaping laterally between the plunger (6) and the microcompartment matrix (4) while pressure is exerted. A plurality of microcompartment matrices (4) are simultaneously retained by the frame structure (1) and are hermetically closed by a corresponding number of associated plungers (6) that are fastened on a base plate (7) or a cover plate (8).