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公开(公告)号：EP2770987A4
公开(公告)日：2015-04-08
申请号：EP12844405
申请日：2012-10-25
申请人： MERCK SHARP & DOHME
发明人： LIM JONGWON , KELLEY ELIZABETH HELEN , METHOT JOEY L , ZHOU HUA , PETROCCHI ALESSIA , MANSOOR UMAR FARUK , O'BOYLE BRENDAN M , GUERIN DAVID JOSEPH , BIENSTOCK COREY E , BOYCE CHRISTOPHER W , DANIELS MATTHEW H , FALCONE DANIELLE , FERGUSON RONALD D II , FEVRIER SALEM , HUANG XIANDAI , LIPFORD KATHRYN ANN , SLOMAN DAVID L , WILSON KEVIN , ZHOU WEI , WITTER DAVID , MALETIC MILANA M , SILIPHAIVANH PHIENG , FISCHER CHRISTIAN
IPC分类号： A61K9/66
CPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D519/00
摘要： Disclosed are the ERK inhibitors of formula (1): and the pharmaceutically acceptable salts thereof. Also disclosed are methods of treating cancer using the compounds of formula (1).
摘要翻译： 公开了式（1）的ERK抑制剂及其药学上可接受的盐。 还公开了使用式（1）的化合物治疗癌症的方法。
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公开(公告)号：EP2900241A4
公开(公告)日：2016-08-10
申请号：EP13840779
申请日：2013-09-26
申请人： MERCK SHARP & DOHME
发明人： WILSON KEVIN J , WITTER DAVID J , SILIPHAIVANH PHIENG , LIPFORD KATHRYN , SLOMAN DAVID , FALCONE DANIELLE , O'BOYLE BRENDAN , MANSOOR UMAR FARUK , LIM JONGWON , METHOT JOEY L , BOYCE CHRISTOPHER , CHEN LEI , DANIELS MATTHEW H , FEVRIER SALEM , HUANG XIANHAI , KURUKULASURIYA RAVI , TONG LING , ZHOU WEI , KOZLOWSKI JOSEPH , MALETIC MILANA M , SHINKRE BIDHAN A , THATAI JAYANTH THIRUVELLORE , BAKSHI RAMAN KUMAR , KARUNAKARAN GANESH BABU
IPC分类号： C07D471/04 , A61K31/437 , A61K31/4375 , A61P35/00 , C07D471/16 , C07D498/16 , C07D519/00
CPC分类号： C07D498/18 , A61K31/437 , A61K31/4375 , A61K31/496 , A61K31/5377 , A61K31/553 , A61K45/06 , C07D471/04 , C07D471/14 , C07D471/16 , C07D498/14 , C07D498/16 , C07D519/00 , A61K2300/00
摘要： Disclosed are the ERK inhibitors of formula (1): and the pharmaceutically acceptable salts thereof. Also disclosed are methods of treating cancer using the compounds of formula (1).
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3.发明公开3-AMINOCYCLOALKYL COMPOUNDS AS RORgammaT INHIBITORS AND USES THEREOF 审中-公开3-AMINOCYCLOALKYL-VERBINDUNGEN ALS ROR-GAMMA-T-HEMMER UND VERWENDUNGEN DAVON
公开(公告)号：EP2920149A4
公开(公告)日：2016-07-27
申请号：EP13829341
申请日：2013-08-14
申请人： MERCK SHARP & DOHME
发明人： BARR KENNETH JAY , MACLEAN JOHN , ZHANG HONGJUN , BERESIS RICHARD THOMAS , ANTHONY NEVILLE , DANIELS MATTHEW H , LAPOINTE BLAIR , SCIAMMETTA NUNZIO
IPC分类号： C07D211/56 , C07D211/92
CPC分类号： C07D487/04 , A61K31/415 , A61K31/4155 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/4545 , A61K31/46 , C07D213/56 , C07D231/56 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D451/02 , C07D471/04 , C07D519/00
摘要： The present invention relates to compounds according to Formula I and pharmaceutically acceptable salts or solvates thereof. Such compounds can be used in the treatment of RORgammaT-mediated diseases or conditions.
摘要翻译： 本发明涉及式I化合物及其药学上可接受的盐或溶剂化物。 这些化合物可用于治疗RORGAMMT介导的疾病或病症。
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公开(公告)号：EP2900223A4
公开(公告)日：2016-06-15
申请号：EP13841687
申请日：2013-09-26
申请人： MERCK SHARP & DOHME
发明人： WILSON KEVIN J , WITTER DAVID J , DANIELS MATTHEW H , ANGELES ANGIE R , SILIPHAIVANH PHIENG , SLOMAN DAVID , O'BOYLE BRENDAN , FALCONE DANIELLE , WHITE CATHERINE , FERGUSON RON , ZHOU WEI , LIPFORD KATHRYN , MANSOOR UMAR FARUK , FEVRIER SALEM , HUANG XIANHAI , KURUKULASURIYA RAVI , RICHARD JUDSON E , TANG SHUYI , BOYCE CHRISTOPHER , KOZLOWSKI JOSEPH , BAKSHI RAMAN KUMAR , KARUNAKARAN GANESH BABU
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
CPC分类号： A61K31/437 , A61K31/4545 , A61K45/06 , C07D471/04
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公开(公告)号：EP2515657A4
公开(公告)日：2013-07-03
申请号：EP10842498
申请日：2010-12-14
申请人： MERCK SHARP & DOHME
发明人： YOUNG JONATHAN , CZAKO BARBARA , ALTMAN MICHAEL , GUERIN DAVID , MARTINEZ MICHELLE , RIVKIN ALEXEY , WILSON KEVIN , LIPFORD KATHRYN , WHITE CATHERINE , SURDI LAURA , CHICHETTI STEPHANIE , DANIELS MATTHEW H , AHEARN SEAN P , FALCONE DANIELLE , OSIMBONI EKUNDAYO
IPC分类号： A01N43/58
CPC分类号： C07D403/04 , C07D237/14 , C07D401/14 , C07D403/10 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/10 , C07D417/14 , C07D471/04
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