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公开(公告)号：EP2900241A4
公开(公告)日：2016-08-10
申请号：EP13840779
申请日：2013-09-26
申请人： MERCK SHARP & DOHME
发明人： WILSON KEVIN J , WITTER DAVID J , SILIPHAIVANH PHIENG , LIPFORD KATHRYN , SLOMAN DAVID , FALCONE DANIELLE , O'BOYLE BRENDAN , MANSOOR UMAR FARUK , LIM JONGWON , METHOT JOEY L , BOYCE CHRISTOPHER , CHEN LEI , DANIELS MATTHEW H , FEVRIER SALEM , HUANG XIANHAI , KURUKULASURIYA RAVI , TONG LING , ZHOU WEI , KOZLOWSKI JOSEPH , MALETIC MILANA M , SHINKRE BIDHAN A , THATAI JAYANTH THIRUVELLORE , BAKSHI RAMAN KUMAR , KARUNAKARAN GANESH BABU
IPC分类号： C07D471/04 , A61K31/437 , A61K31/4375 , A61P35/00 , C07D471/16 , C07D498/16 , C07D519/00
CPC分类号： C07D498/18 , A61K31/437 , A61K31/4375 , A61K31/496 , A61K31/5377 , A61K31/553 , A61K45/06 , C07D471/04 , C07D471/14 , C07D471/16 , C07D498/14 , C07D498/16 , C07D519/00 , A61K2300/00
摘要： Disclosed are the ERK inhibitors of formula (1): and the pharmaceutically acceptable salts thereof. Also disclosed are methods of treating cancer using the compounds of formula (1).
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2.发明公开HETEROCYCLE-SUBSTITUED TETRACYCLIC COMPOUNDS AND METHODS OF USE THEREOF FOR TREATMENT OF VIRAL DISEASES 审中-公开杂环取代的FOR USE四环CONNECTIONS及其方法进行病毒疾病治疗
公开(公告)号：EP2945952A4
公开(公告)日：2016-07-20
申请号：EP13871363
申请日：2013-12-31
申请人： MERCK SHARP & DOHME
发明人： YU WENSHENG , TONG LING , KOZLOWSKI JOSEPH A , SELYUTIN OLEG , CHEN LEI , KIM JAE-HUN , SHA DEYOU , RIZVI RAZIA , SHANKAR BANDARPALLE , HU BIN , ZHONG BIN , WANG DAHAI , HAO JINGLAI , WEI WEI , JI TAO , ZAN SHUAI
IPC分类号： C07D498/04 , A61K31/5365 , A61K45/06 , A61P31/14 , C07D409/14
CPC分类号： A61K31/5365 , A61K31/4985 , A61K31/7056 , A61K31/7072 , A61K45/06 , C07D498/04 , C07D513/04 , A61K2300/00
摘要： The present invention relates to novel Heterocycle-Substituted Tetracyclic Compounds of Formula (I): (I) and pharmaceutically acceptable salts thereof, wherein A, A′, R2 R3, R4 and R are as defined herein. The present invention also relates to compositions comprising at least one Heterocycle-Substituted Tetracyclic Compound, and methods of using the Heterocycle-Substituted Tetracyclic Compounds for treating or preventing HCV infection in a patient.
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3.发明公开SUBSTITUTED PYRIDINE AND PYRIMIDINE DERIVATIVES AND THEIR USE IN TREATING VIRAL INFECTIONS 有权取代的嘧啶衍生物及其吡啶和治疗病毒感染
公开(公告)号：EP2536410A4
公开(公告)日：2013-10-09
申请号：EP11745338
申请日：2011-02-18
发明人： ARASAPPAN ASHOK , NJOROGE GEORGE F , KWONG CECIL D , ANANTHAN SUBRAMANIAM , BENNETT FRANK , GENG FENG , GIRIJAVALLABHAN VINAY M , HUANG YUHUA , KEZAR HOLLIS S III , MADDRY JOSEPH A , REYNOLDS ROBERT C , ROYCHOWDHURY ABHIJIT , FOWLER ANITA T , SECRIST JOHN A III , KOZLOWSKI JOSEPH A , SHANKAR BANDARPALLE B , TONG LING , KIM SEONG HEON , MACCOSS MALCOLM
IPC分类号： A61K31/506 , A61P31/14
CPC分类号： A61K31/506 , A61K45/06 , C07D403/04 , C07D413/04 , C07D417/04 , C07D417/14 , C07D491/048 , C07D513/04
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4.发明公开THIOPHENE-SUBSTITUTED TETRACYCLIC COMPOUNDS AND METHODS OF USE THEREOF FOR TREATMENT OF VIRAL DISEASES 审中-公开取代四环噻吩和方法及其使用病毒疾病治疗
公开(公告)号：EP2945953A4
公开(公告)日：2016-07-20
申请号：EP13872073
申请日：2013-12-31
申请人： MERCK SHARP & DOHME
发明人： TONG LING , YU WENSHENG , KOZLOWSKI JOSEPH A , CHEN LEI , SELYUTIN OLEG , KIM SEONG HEON , DWYER MICHAEL , HU BIN , ZHONG BIN , WANG DAHAI , HAO JINGLAI , SHEN CHANGMAO , LEI ZHIXIN , WANG WEIJUN
IPC分类号： C07D498/04 , A61K31/5365 , A61K45/06 , A61P31/14 , C07D409/14
CPC分类号： C07D498/04 , A61K31/4985 , A61K31/5365 , A61K31/7056 , A61K31/7072 , A61K38/005 , A61K38/212 , A61K45/06 , C07D519/00 , A61K2300/00
摘要： Thiophene-substituted tetracyclic compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein A, A′, R2, R3, R4 and R5 are as defined herein. The compositions comprising at least one thiophene-substituted tetracyclic compound, and methods of using the thiophene-substituted tetracyclic compounds for treating or preventing HCV infection in a patient are also provided.
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5.发明公开FUSED TETRACYCLIC HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES 审中-公开KONDENSIERTE TETRACYCLISCHE UND杂种洋葱VERBINDUNGEN SOWIE VERFAHREN ZUR VERWENDUNG DAVON ZUR BEHANDLUNG VON VIRENERKRANKUNGEN
公开(公告)号：EP3083634A4
公开(公告)日：2017-06-07
申请号：EP14870683
申请日：2014-12-15
申请人： MERCK SHARP & DOHME
发明人： KOZLOWSKI JOSEPH , COBURN CRAIG , YU WENSHENG , TONG LING , HU BIN , ZHONG BIN , HAO JINGLAI , WANG DAHAI , JI TAO
IPC分类号： C07D493/04 , A61P31/12
CPC分类号： C07D405/14 , A61K31/4155 , A61K31/4178 , A61K31/4985 , A61K31/7072 , A61K45/06 , C07D493/04 , A61K2300/00
摘要： The present invention relates to novel Fused Tetracyclic Heterocyclic Compounds of Formula I: (I), wherein A, A', R2A, R2B, R7, R8, R9, and R10 are defined herein. The compounds and their pharmaceutically acceptable salts are useful for the prophylaxis or treatment of infection by HCV and the prophylaxis, treatment, or delay in the onset of disease caused by HCV. The present invention also relates to pharmaceutical compositions comprising at least one Fused Tetracyclic Heterocyclic Compound, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines, and methods of using the Fused Tetracyclic Heterocyclic Compounds for treating or preventing HCV infection in a patient.
摘要翻译： 本发明涉及式I的新型稠合四环杂环化合物：其中A，A'，R2A，R2B，R7，R8，R9和R10如本文所定义。 这些化合物及其药学上可接受的盐可用于预防或治疗由HCV引起的感染和由HCV引起的疾病发作的预防，治疗或延迟。 本发明还涉及药物组合物，其包含至少一种稠合四环杂环化合物，任选地与其他抗病毒剂，免疫调节剂，抗生素或疫苗组合，以及使用稠合四环杂环化合物治疗或预防患者中HCV感染的方法。
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6.发明公开SILYL-CONTAINING HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES 审中-公开硅杂环衍生物及其用于治疗病毒疾病的方法
公开(公告)号：EP2755981A4
公开(公告)日：2015-03-25
申请号：EP12831707
申请日：2012-09-11
申请人： MERCK SHARP & DOHME
发明人： DWYER MICHAEL P , KEERTIKAR KARTIK M , ZENG QINGBEI , MAZZOLA ROBERT D JR , YU WENSHENG , TANG HAIQUN , KIM SEONG HEON , TONG LING , ROSENBLUM STUART B , KOZLOWSKI JOSEPH A , NAIR ANILKUMAR GOPINADHAN
IPC分类号： C07F7/08 , A61K31/695 , A61K45/06 , A61P31/12
CPC分类号： C07F7/10 , A61K31/695 , A61K45/06 , A61K2201/094 , A61K2300/00 , C07F7/0816
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7.发明公开TETRACYCLIC HETEROCYCLE COMPOUNDS FOR TREATING HEPATITIS C VIRAL INFECTION 审中-公开TETRA CYCLICAL HETEROFLEXIBLE CYCLE化合物C型肝炎病毒感染的治疗
公开(公告)号：EP2621932A4
公开(公告)日：2014-03-26
申请号：EP11828123
申请日：2011-09-28
申请人： MERCK SHARP & DOHME
发明人： DWYER MICHAEL P , KEERTIKAR KARTIK M , COBURN CRAIG A , WU HAO , HU BIN , ZHONG BIN , ZHANG CHENGREN , DAN ZHIGANG , TONG LING , YU WENSHENG
IPC分类号： C07D498/04 , A61K31/437 , A61K31/4985 , A61K31/5365 , A61P31/14 , C07D471/04 , C07D471/22 , C07D487/04 , C07D491/22 , C07D493/22
CPC分类号： C07D491/052 , A61K31/437 , A61K31/4985 , A61K31/5365 , A61K45/06 , C07D403/14 , C07D405/14 , C07D471/04 , C07D471/22 , C07D487/04 , C07D493/22 , C07D498/04 , A61K2300/00
摘要： Tetracyclic heterocycle compounds of formula (I) and pharmaceutically acceptable salts thereof are provided, wherein A, A', G, R1, R15, U, V, V', W, W, X, X', Y and Y' are as defined in the invention. The pharmaceutical compositions comprising these compounds and the use of the compounds for treating hepatitis C virus (HCV) infection are also provided.
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8.发明公开TETRACYCLIC INDOLE DERIVATIVES FOR TREATING HEPATITIS C VIRUS INFECTION 审中-公开用于治疗丙型肝炎病毒感染TETRA CYCLICAL吲哚衍生物
公开(公告)号：EP2621931A4
公开(公告)日：2014-03-19
申请号：EP11827912
申请日：2011-09-28
申请人： MERCK SHARP & DOHME
发明人： KOZLOWSKI JOSEPH A , ROSENBLUM STUART B , COBURN CRAIG A , SHANKAR BANDARPALLE B , ANILKUMAR G NAIR , CHEN LEI , DWYER MICHAEL P , JIANG YUEHENG , KEERTIKAR KARTIK M , LAVEY BRIAN J , SELYUTIN OLEG B , TONG LING , WONG MICHAEL , YANG DE-YI , YU WENSHENG , ZHOU GUOWEI , WU HAO , HU BIN , ZHONG BIN , SUN FEI , JI TAO , SHEN CHANGMAO , RIZVI RAZIA , ZENG QINGBEI
IPC分类号： C07D498/04 , A61K31/437 , A61K31/4985 , A61K31/5365 , A61P31/12 , A61P31/14 , C07D471/04 , C07D487/04
CPC分类号： C07D498/04 , A61K31/437 , A61K31/4985 , A61K31/5365 , A61K45/06 , C07D471/04 , C07D487/04 , A61K2300/00
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