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1.发明公开
公开(公告)号：EP3185865A4
公开(公告)日：2018-05-02
申请号：EP15836358
申请日：2015-08-24
发明人： ARASAPPAN ASHOK , BUNGARD CHRISTOPHER JAMES , FRIE JESSICA L , HAN YONGXIN , HOYT SCOTT B , MANLEY PETER J , MEISSNER ROBERT S , PERKINS JAMES J , SEBHAT IYASSU K , WILKENING ROBERT R , LEAVITT KENNETH J
IPC分类号： A61K31/4375
CPC分类号： C07D471/04 , A61K31/4375
摘要： The present invention provides quinoline carboxamide and quinoline carbonitrile compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein R1, R2, L, X1, X2, and X3, are as defined herein. The compounds of the invention, and pharmaceutically acceptable salts thereof, and pharmaceutical compositions comprising them, are useful as non-competitive mGluR2 antagonists, or mGluR2 negative allosteric modulators (NAMs), and may be useful in methods of treating a person in need thereof for diseases or disorders in which the mGluR2-NAM receptor plays a causative role, such as Alzheimer's disease, cognitive impairment, schizophrenia and other mood disorders, pain disorders and sleep disorders.
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2.发明公开QUINOLINE CARBOXAMIDE AND QUINOLINE CARBONITRILE DERIVATIVES AS mGluR2-NEGATIVE ALLOSTERIC MODULATORS, COMPOSITIONS, AND THEIR USE 有权作为MGLUR2阴离子调节剂，组合物及其用途的羧甲基羧酰胺和羧甲基碳纳米管衍生物
公开(公告)号：EP2775841A4
公开(公告)日：2015-05-06
申请号：EP12846579
申请日：2012-10-26
申请人： MERCK SHARP & DOHME
发明人： BUNGARD CHRISTOPHER JAMES , CONVERSO ANTONELLA , DE LEON PABLO , HANNEY BARBARA , HARTINGH TIMOTHY JOHN , MANIKOWSKI JESSE JOSEF , MANLEY PETER J , MEISSNER ROBERT , MENG ZHAOYANG , PERKINS JAMES J , RUDD MICHAEL T , RUDD MICHAEL T , SHU YOUHENG
IPC分类号： A61K31/4725 , A61P25/04 , A61P25/20 , A61P25/28 , C07D215/48 , C07D401/06 , C07D401/14
CPC分类号： C07D413/14 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/4985 , A61K31/506 , A61K31/5377 , A61K31/541 , C07D215/48 , C07D401/04 , C07D401/06 , C07D401/14 , C07D409/04 , C07D413/06 , C07D417/06 , C07D417/14 , C07D471/04 , C07D491/10
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3.发明公开INHIBITORS OF CATECHOL O-METHYL TRANSFERASE AND THEIR USE IN THE TREATMENT OF PSYCHOTIC DISORDERS 审中-公开儿茶酚-O-甲基转移酶抑制剂及其在治疗精神障碍中的用途
公开(公告)号：EP2542077A4
公开(公告)日：2013-08-21
申请号：EP11751124
申请日：2011-02-28
申请人： MERCK SHARP & DOHME
发明人： WOLKENBERG SCOTT , BARROW JAMES C , HARRISON SCOTT T , TROTTER B WESLEY , NANDA KAUSIK K , MANLEY PETER J , ZHAO ZHIJIAN
IPC分类号： A01N43/40 , A61K31/44 , C07D213/69 , C07D213/84 , C07D213/85 , C07D401/04 , C07D413/10 , C07D417/04
CPC分类号： C07D213/69 , C07D211/86 , C07D213/84 , C07D213/85 , C07D401/04 , C07D413/10 , C07D417/04
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4.发明公开IMIDAZOISOINDOLE NEUROPEPTIDE S RECEPTOR ANTAGONISTS 审中-公开IMIDAZOISOINDOL - 神经肽-S-REZEPTORANTAGONISTEN
公开(公告)号：EP2365748A4
公开(公告)日：2012-05-02
申请号：EP09826568
申请日：2009-11-03
申请人： MERCK SHARP & DOHME
发明人： MANLEY PETER J , NANDA KAUSIK K , TROTTER B WESLEY
IPC分类号： A01N43/38 , A61K31/40 , C07D487/04
CPC分类号： C07D487/04
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公开(公告)号：EP1827436A4
公开(公告)日：2011-08-10
申请号：EP05853256
申请日：2005-12-09
申请人： MERCK SHARP & DOHME
发明人： ARRUDA JEANNIE M , CAMPBELL BRIAN T , COSFORD NICHOLAS D P , HOFFMAN JACOB M , HU ESSA H , LAYTON MARK E , LI YIWEI , LIANG JUN , RODZINAK KEVIN J , SIU TONY , STEARNS BRIAN A , TEHRANI LIDA R , MANLEY PETER J , BILODEAU MARK T
IPC分类号： A61K31/4745 , C07D471/02
CPC分类号： C07D471/04
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公开(公告)号：EP1737861A4
公开(公告)日：2010-04-28
申请号：EP05732864
申请日：2005-04-05
申请人： MERCK SHARP & DOHME
发明人： BILODEAU MARK T , CHEN CHIXU , COSFORD NICHOLAS D P , EASTMAN BRIAN W , HARTNETT JOHN C , HU ESSA H , MANLEY PETER J , NEILSON LOU ANNE , TEHRANI LIDA R , WU ZHICAI
IPC分类号： C07D471/04 , A61K31/4375 , A61K31/519 , A61P35/00 , C07D487/04
CPC分类号： C07D471/04 , C07D519/00
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7.发明公开INHIBITORS OF CATECHOL O-METHYL TRANSFERASE AND THEIR USE IN THE TREATMENT OF PSYCHOTIC DISORDERS 审中-公开HEMMER DER CATECHOL-O-METHYL-TRANSFERASE UND IHRE VERWENDUNG BEI DER BEHANDLUNG PSYCHOTISCHERSTÖRUNGEN
公开(公告)号：EP2542076A4
公开(公告)日：2015-01-14
申请号：EP11751121
申请日：2011-02-28
申请人： MERCK SHARP & DOHME
发明人： WOLKENBERG SCOTT , BARROW JAMES C , POSLUSNEY MICHAEL S , HARRISON SCOTT T , TROTTER B WESLEY , MULHEARN JAMES , NANDA KAUSIK K , MANLEY PETER J , ZHAO ZHIJIAN , SCHUBERT JEFFREY W , KETT NATHAN , ZARTMAN AMY
CPC分类号： C07F5/025 , A61K31/4412 , A61K31/4418 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/5377 , A61K31/541 , A61K31/69 , A61K45/06 , C07D213/69 , C07D213/73 , C07D213/74 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/14 , C07D413/10 , C07D413/12 , C07D417/10 , C07D471/04
摘要： The present invention relates to 4-pyridinone compounds which are inhibitors of catechol O-methyltransferase (COMT), and are useful in the treatment and prevention of neurological and psychiatric disorders and diseases in which COMT enzyme is involved. The present invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which COMT is involved.
摘要翻译： 本发明涉及作为儿茶酚O-甲基转移酶（COMT）的抑制剂的4-吡啶酮化合物，可用于治疗和预防涉及COMT酶的神经和精神疾病和疾病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及COMT的疾病中的用途。
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