公开(公告)号：EP2736338A4

公开(公告)日：2014-12-10

申请号：EP12817088

申请日：2012-07-20

申请人： MERCK SHARP & DOHME

发明人： MENG ZHAOYANG ,  PATEL MEHUL F ,  SIDDIQUI M ARSHAD ,  REDDY PANDURANGA ADULLA P ,  NAN YANG

IPC分类号： A01N43/90 ,  A61K31/519 ,  C07D487/14 ,  C07D519/00

CPC分类号： C07D487/14 ,  A61K31/519 ,  C07D519/00

摘要： The present invention relates to certain pyrazolo[1,5-a]pyrrolo[3,2-e]pyrimidine and dipyrazolopyrimidine compounds of Formula (I) as inhibitors of mammalian Target Of Rapamycin (mTOR) kinase, which is also known as FRAP, RAFT, RAPT or SEP. The compounds may be used in the treatment of cancer and other disorders where mTOR is deregulated. The present invention further provides pharmaceutical compositions comprising the pyrazolo[1,5-a]pyrrolo[3,2-e]pyrimidine or dipyrazolopyrimidine compounds.

公开(公告)号：EP2525659A4

公开(公告)日：2013-08-28

申请号：EP11735040

申请日：2011-01-18

申请人： MERCK SHARP & DOHME

发明人： SIDDIQUI M ARSHAD ,  NAN YANG ,  PATEL MEHUL F ,  REDDY PANDURANGA ADULLA P ,  MANSOOR UMAR FARUK ,  MENG ZHAOYANG ,  VITHARANA LALANTHI DILRUKSHI ,  ZHAO LIANYUN ,  MANDAL AMIT K ,  LIU DUAN ,  TANG SHUYI ,  MCRINER ANDREW ,  BELANGER DAVID B ,  CURRAN PATRICK J ,  DAI CHAOYANG ,  ANGELES ANGIE R ,  YANG LIPING ,  DANIELS MATTHEW HERSH

IPC分类号： A01N43/90

CPC分类号： C07D471/08 ,  C07D487/04 ,  C07D487/08 ,  C07D491/147 ,  C07D498/08 ,  C07D513/08 ,  C07D519/00

摘要： The present invention provides Pyrazolopyrimidine Compounds of Formula (I): wherein L, T, Z, U, V, W, R3, R6, R7, R8, and m are as defined herein, and pharmaceutically acceptable salts of such Pyrazolopyrimidine Compounds. The Pyrazolopyrimidine Compounds are useful in the treatment of cancer and other diseases or disorders wherein mTOR is deregulated.