公开(公告)号：EP2945952A4

公开(公告)日：2016-07-20

申请号：EP13871363

申请日：2013-12-31

申请人： MERCK SHARP & DOHME

发明人： YU WENSHENG ,  TONG LING ,  KOZLOWSKI JOSEPH A ,  SELYUTIN OLEG ,  CHEN LEI ,  KIM JAE-HUN ,  SHA DEYOU ,  RIZVI RAZIA ,  SHANKAR BANDARPALLE ,  HU BIN ,  ZHONG BIN ,  WANG DAHAI ,  HAO JINGLAI ,  WEI WEI ,  JI TAO ,  ZAN SHUAI

IPC分类号： C07D498/04 ,  A61K31/5365 ,  A61K45/06 ,  A61P31/14 ,  C07D409/14

CPC分类号： A61K31/5365 ,  A61K31/4985 ,  A61K31/7056 ,  A61K31/7072 ,  A61K45/06 ,  C07D498/04 ,  C07D513/04 ,  A61K2300/00

摘要： The present invention relates to novel Heterocycle-Substituted Tetracyclic Compounds of Formula (I): (I) and pharmaceutically acceptable salts thereof, wherein A, A′, R2 R3, R4 and R are as defined herein. The present invention also relates to compositions comprising at least one Heterocycle-Substituted Tetracyclic Compound, and methods of using the Heterocycle-Substituted Tetracyclic Compounds for treating or preventing HCV infection in a patient.

公开(公告)号：EP2945953A4

公开(公告)日：2016-07-20

申请号：EP13872073

申请日：2013-12-31

申请人： MERCK SHARP & DOHME

发明人： TONG LING ,  YU WENSHENG ,  KOZLOWSKI JOSEPH A ,  CHEN LEI ,  SELYUTIN OLEG ,  KIM SEONG HEON ,  DWYER MICHAEL ,  HU BIN ,  ZHONG BIN ,  WANG DAHAI ,  HAO JINGLAI ,  SHEN CHANGMAO ,  LEI ZHIXIN ,  WANG WEIJUN

IPC分类号： C07D498/04 ,  A61K31/5365 ,  A61K45/06 ,  A61P31/14 ,  C07D409/14

CPC分类号： C07D498/04 ,  A61K31/4985 ,  A61K31/5365 ,  A61K31/7056 ,  A61K31/7072 ,  A61K38/005 ,  A61K38/212 ,  A61K45/06 ,  C07D519/00 ,  A61K2300/00

摘要： Thiophene-substituted tetracyclic compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein A, A′, R2, R3, R4 and R5 are as defined herein. The compositions comprising at least one thiophene-substituted tetracyclic compound, and methods of using the thiophene-substituted tetracyclic compounds for treating or preventing HCV infection in a patient are also provided.