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1.发明公开HETEROCYCLE-SUBSTITUED TETRACYCLIC COMPOUNDS AND METHODS OF USE THEREOF FOR TREATMENT OF VIRAL DISEASES 审中-公开杂环取代的FOR USE四环CONNECTIONS及其方法进行病毒疾病治疗
公开(公告)号：EP2945952A4
公开(公告)日：2016-07-20
申请号：EP13871363
申请日：2013-12-31
申请人： MERCK SHARP & DOHME
发明人： YU WENSHENG , TONG LING , KOZLOWSKI JOSEPH A , SELYUTIN OLEG , CHEN LEI , KIM JAE-HUN , SHA DEYOU , RIZVI RAZIA , SHANKAR BANDARPALLE , HU BIN , ZHONG BIN , WANG DAHAI , HAO JINGLAI , WEI WEI , JI TAO , ZAN SHUAI
IPC分类号： C07D498/04 , A61K31/5365 , A61K45/06 , A61P31/14 , C07D409/14
CPC分类号： A61K31/5365 , A61K31/4985 , A61K31/7056 , A61K31/7072 , A61K45/06 , C07D498/04 , C07D513/04 , A61K2300/00
摘要： The present invention relates to novel Heterocycle-Substituted Tetracyclic Compounds of Formula (I): (I) and pharmaceutically acceptable salts thereof, wherein A, A′, R2 R3, R4 and R are as defined herein. The present invention also relates to compositions comprising at least one Heterocycle-Substituted Tetracyclic Compound, and methods of using the Heterocycle-Substituted Tetracyclic Compounds for treating or preventing HCV infection in a patient.
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公开(公告)号：EP2470021A4
公开(公告)日：2013-01-16
申请号：EP10812498
申请日：2010-08-17
申请人： MERCK SHARP & DOHME
发明人： EDMONDSON SCOTT D , BERGER RICHARD , CHANG LEHUA , COLANDREA VINCENT J , HALE JEFFREY J , HARPER BART , KAR NAM FUNG , LI BING , MORRIELLO GREGORI J , MOYES CHRISTOPHER R , SHA DEYOU , SHEN DONG-MING , WANG LIPING , WENDT HARVEY R , ZHU CHENG
CPC分类号： C07D403/14 , C07D401/04 , C07D401/10 , C07D401/14 , C07D403/10 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/10 , C07D491/048 , C07D491/107 , C07D491/147 , C07D491/20 , C07D495/10 , C07D495/20 , C07D497/10 , C07D498/04 , C07D513/04 , C07D513/20
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公开(公告)号：EP3134408A4
公开(公告)日：2018-01-03
申请号：EP15783339
申请日：2015-04-21
申请人： MERCK SHARP & DOHME
发明人： LIM YEON-HEE , GUO ZHUYAN , ALI AMJAD , EDMONDSON SCOTT D , LIU WEIGUO , GALLO-ETIENNE GIOCONDA V , WU HEPING , GAO YING-DUO , STAMFORD ANDREW M , YU YOUNONG , KEVIN NANCY J , ANAND RAJAN , SHA DEYOU , NEELAMKAVIL SANTHOSH F , HUSSAIN ZAHID , KUMAR PUNEET , MONINGKA REMOND , DUFFY JOSEPH L , XU JIAYI , JIANG YU , SONE HIROKI , CHAKRABARTI ANJAN
IPC分类号： C07D471/10 , A61K31/438 , C07D498/20
CPC分类号： C07D498/20 , C07D471/10 , C07D487/10 , C07D498/10 , C07F9/6561
摘要： The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
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4.发明公开3'-PYRIDYL SUBSTITUTED- 6,6-DIFLUORO BICYCLIC HIMBACINE DERIVATIVES 审中-公开3-吡啶基取代的6,6-二氟双环HIMBACINDERIVATE
公开(公告)号：EP3035928A4
公开(公告)日：2017-03-08
申请号：EP14837408
申请日：2014-08-18
申请人： MERCK SHARP & DOHME
IPC分类号： A61K31/44 , A61K31/4365 , A61K31/444 , A61K31/60 , A61P9/00 , C07D405/06 , C07D405/14 , C07D409/14
CPC分类号： A61K31/60 , A61K31/343 , A61K31/4365 , A61K31/444 , A61K45/06 , C07D405/14 , C07D409/04 , C07D409/14 , A61K2300/00
摘要： The compounds of the invention are effective inhibitors of the PAR-1 receptor. The inventive compounds may be used for the treatment or prophylaxis of disease states such as ASC, secondary prevention of myocardial infarction or stroke, or PAD.
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公开(公告)号：EP2844252A4
公开(公告)日：2015-10-14
申请号：EP13784511
申请日：2013-04-26
申请人： MERCK SHARP & DOHME
发明人： ACTON JOHN J III , VACHAL PETR , SHA DEYOU , DROPINSKI JAMES F , CHU LIN , ONDEYKA DEBRA , KIM ALEXANDER J , COLANDREA VINCENT J , ZANG YI , ZHANG FENGQI , DONG GUIZHEN
IPC分类号： A61K31/443 , A61K31/444 , A61K31/506 , A61P3/06 , A61P9/10 , C07D413/14 , C07D417/14
CPC分类号： C07D417/14 , A61K31/444 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D413/14
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