公开(公告)号：EP3204385A4

公开(公告)日：2018-03-28

申请号：EP15848373

申请日：2015-10-08

申请人： MERCK SHARP & DOHME

发明人： UJJAINWALLA FEZ ,  TAN JOHN QIANG ,  DANG QUN ,  SINZ CHRISTOPHER J ,  WANG MING ,  CHEN YILI ,  CAI JIAQIANG

IPC分类号： C07D239/36 ,  A61P7/06 ,  C07D413/06

CPC分类号： C07D239/36 ,  A61P7/06 ,  C07D413/06

摘要： The present invention concerns compounds of Formula I that inhibit HIF prolyl hydroxylase, their use for enhancing endogenous production of erythropoietin, and for treating conditions associated with reduced endogenous production of erythropoietin such as anemia and like conditions, as well as pharmaceutical compositions comprising such a compound and a pharmaceutical carrier.

公开(公告)号：EP3204363A4

公开(公告)日：2018-04-04

申请号：EP15849713

申请日：2015-10-08

申请人： MERCK SHARP & DOHME

发明人： UJJAINWALLA FEZ ,  TAN JOHN QIANG ,  DANG QUN ,  SINZ CHRISTOPHER J ,  CRESPO ALEJANDRO ,  WANG MING ,  CHEN YILI ,  CAI JIAQIANG ,  WU FAN ,  DU XIAOXING

IPC分类号： C07D239/26 ,  A61K31/505 ,  A61P7/06

CPC分类号： C07D239/36 ,  C07D239/34 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12

摘要： The present invention concerns compounds of Formula I that inhibit HIF prolyl hydroxylase, their use for enhancing endogenous production of erythropoietin, and for treating conditions associated with reduced endogenous production of erythropoietin such as anemia and like conditions, as well as pharmaceutical compositions comprising such a compound and a pharmaceutical carrier.

公开(公告)号：EP3204384A4

公开(公告)日：2018-04-18

申请号：EP15848319

申请日：2015-10-08

申请人： MERCK SHARP & DOHME

发明人： UJJAINWALLA FEZ ,  TAN JOHN QIANG ,  DANG QUN ,  SINZ CHRISTOPHER J ,  WANG MING ,  CAI JIAQIANG ,  DU XIAOXING ,  CHEN YILI

IPC分类号： C07D471/20 ,  A61K31/4412 ,  A61K31/4439 ,  A61P7/08 ,  C07D401/14 ,  C07D471/04

CPC分类号： C07D213/82 ,  A61P7/08 ,  C07D401/04

摘要： The present invention concerns compounds of formula I that inhibit HIF prolyl hydroxylase, their use for enhancing endogenous production of erythropoietin, and for treating conditions associated with reduced endogenous production of erythropoietin such as anemia and like conditions, as well as pharmaceutical compositions comprising such a compound and a pharmaceutical carrier.