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公开(公告)号：EP3197452A4
公开(公告)日：2018-02-28
申请号：EP15844485
申请日：2015-09-23
发明人： CAI JIAQIANG , CRESPO ALEJANDRO , DEBENHAM JOHN , DU XIAOXING , LIU PING , LIU RONGQIANG , MADSEN-DUGGAN CRISTINA B , QUAN WEIGUO , SINZ CHRISTOPHER , WANG LIPING
IPC分类号： C07D491/048 , A61K31/4355 , A61P7/06 , C07D495/04
CPC分类号： C07D495/04 , A61P7/06 , C07D491/048
摘要： The present invention concerns compounds of formula I or a pharmaceutically acceptable salt thereof which inhibit HIF prolyl hydroxylase, their use for enhancing endogenous production of erythropoietin, and for treating conditions associated with reduced endogenous production of erythropoietin such as anemia and like conditions, as well as pharmaceutical compositions comprising such a compound and a pharmaceutical carrier.
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公开(公告)号：EP3204363A4
公开(公告)日：2018-04-04
申请号：EP15849713
申请日：2015-10-08
申请人： MERCK SHARP & DOHME
发明人： UJJAINWALLA FEZ , TAN JOHN QIANG , DANG QUN , SINZ CHRISTOPHER J , CRESPO ALEJANDRO , WANG MING , CHEN YILI , CAI JIAQIANG , WU FAN , DU XIAOXING
IPC分类号： C07D239/26 , A61K31/505 , A61P7/06
CPC分类号： C07D239/36 , C07D239/34 , C07D401/12 , C07D403/12 , C07D405/12
摘要： The present invention concerns compounds of Formula I that inhibit HIF prolyl hydroxylase, their use for enhancing endogenous production of erythropoietin, and for treating conditions associated with reduced endogenous production of erythropoietin such as anemia and like conditions, as well as pharmaceutical compositions comprising such a compound and a pharmaceutical carrier.
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公开(公告)号：EP2958562A4
公开(公告)日：2016-08-10
申请号：EP14754282
申请日：2014-02-20
申请人： MERCK SHARP & DOHME
发明人： BROCKUNIER LINDA L , CHEN HELEN , CHOBANIAN HARRY R , CLEMENTS MATTHEW J , CRESPO ALEJANDRO , DEMONG DUANE E , GUO YAN , HAGMANN WILLIAM K , MARCANTONIO KAREN M , MILLER MICHAEL , PIO BARBARA , PLUMMER CHRISTOPHER W , XIAO DONG
IPC分类号： A61K31/357 , A61P3/10
CPC分类号： C07D493/04 , A61K31/352 , A61K31/416 , A61K31/422 , A61K31/427 , A61K31/436 , A61K31/4433 , A61K31/444 , A61K31/497 , A61K31/538 , A61K45/06 , C07D201/00 , C07D311/04 , C07D311/28 , C07D319/20 , C07D405/04 , C07D405/06 , C07D405/10 , C07D405/14 , C07D413/10 , C07D417/04 , C07D491/048 , C07D491/052
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公开(公告)号：EP3197455A4
公开(公告)日：2018-04-04
申请号：EP15845304
申请日：2015-09-23
发明人： CAI JIAQIANG , COLANDREA VINCENT , CRESPO ALEJANDRO , DEBENHAM JOHN , DU XIAOXING , GUIADEEN DEODIALSINGH , LIU PING , LIU RONGQIANG , MADSEN DUGGAN CRISTINA B , MCCOY JOSHUA G , QUAN WEIGUO , SINZ CHRISTOPHER , WANG LIPING
IPC分类号： C07D215/56 , A61K31/436 , A61P7/06 , C07D221/22 , C07D417/06 , C07D471/04 , C07D491/052
CPC分类号： C07D491/052 , C07D215/56 , C07D221/22 , C07D417/06 , C07D471/04
摘要： The present invention concerns a compound of formula I or a pharmaceutically acceptable salt thereof, which inhibit HIF prolyl hydroxylase, their use for enhancing endogenous production of erythropoietin, and for treating conditions associated with reduced endogenous production of erythropoietin such as anemia and like conditions, as well as pharmaceutical compositions comprising such a compound and a pharmaceutical carrier.
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公开(公告)号：EP3285581A1
公开(公告)日：2018-02-28
申请号：EP16769472
申请日：2016-03-21
申请人： MERCK SHARP & DOHME
发明人： SHEN DONG-MING , YANG MENG , CRESPO ALEJANDRO , WILSON JONATHAN E , MCCRACKEN TROY , WANG DEPING , PARKER DANN , GUO ZACK ZHIQIANG
IPC分类号： A01N43/90 , A61K31/535
CPC分类号： C07D403/04 , C07D401/14 , C07D405/14
摘要： The present invention is directed to pyrimidine carboxamide compounds of formula I which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis, Parkinson's disease, Parkinson's disease dementia (PDD), or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.
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6.发明公开
公开(公告)号：EP3116862A4
公开(公告)日：2017-08-30
申请号：EP15760695
申请日：2015-03-06
发明人： WILLIAMS PETER D , MCCAULEY JOHN A , BUNGARD CHRISTOPHER J , BENNETT DAVID JONATHAN , WADDELL SHERMAN T , MORRIELLO GREGORI J , CHANG LEHUA , DWYER MICHAEL P , HOLLOWAY M KATHARINE , CRESPO ALEJANDRO , CHU XIN-JIE , WISCOUNT CATHERINE , LOUGHRAN H MARIE , MANIKOWSKI JESSE J , KEERTIKAR KARTIK M , HU BIN , ZHONG BIN , JI TAO
IPC分类号： C07D513/08 , A61K31/554 , A61P31/18
CPC分类号： C07D513/08 , A61K31/554 , A61K45/06
摘要： The present invention is directed to compounds of Formula I pharmaceutical compositions comprising the same, and their use in the inhibition of HIV protease, the inhibition of HIV replication, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS.
摘要翻译： 本发明涉及式I化合物，包含其的药物组合物，以及它们在抑制HIV蛋白酶，抑制HIV复制，预防HIV感染，治疗HIV感染以及预防， 治疗和延缓艾滋病的发病或进展。
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公开(公告)号：EP2665707A1
公开(公告)日：2013-11-27
申请号：EP12736795
申请日：2012-01-19
申请人： MERCK SHARP & DOHME
发明人： CRESPO ALEJANDRO , LAN PING , MAL RUDRAJIT , OGAWA ANTHONY , SHEN HONG , SINCLAIR PETER J , SUN ZHONGXIANG , BUNTE ELLEN K VANDE , WU ZHICAI , LIU KUN , DEVITA ROBERT J , SHEN DONG-MING , SHU MIN , TAN JOHN QIANG , QI CHANGHE , WANG YUGUANG , BERESIS RICHARD
IPC分类号： C07D209/08 , A61K31/404 , A61K31/416 , A61P3/00 , A61P9/04 , A61P9/06 , A61P9/12 , A61P13/12 , C07D209/10 , C07D231/56 , C07D403/04 , C07D403/06 , C07D405/06 , C07D413/06
CPC分类号： C07D413/06 , A61K31/404 , A61K31/4045 , A61K31/405 , A61K31/416 , A61K31/4196 , A61K31/422 , A61K31/4245 , A61K45/06 , C07D209/08 , C07D209/10 , C07D231/56 , C07D403/04 , C07D403/06 , C07D405/06
摘要： Disclosed are the compounds of the Formula (I) as well as pharmaceutically acceptable salts thereof, which are useful for treating aldosterone-mediated diseases. The processes for preparing compounds of the Formula (I), the use for the therapy and prophylaxis of the abovementioned diseases and for preparing pharmaceuticals for this purpose, and the pharmaceutical compositions which comprise compounds of the formula (I) are disclosed too.
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公开(公告)号：EP3270926A4
公开(公告)日：2018-08-01
申请号：EP16765473
申请日：2016-03-11
申请人： MERCK SHARP & DOHME
发明人： SHEN DONG-MING , SINZ CHRISTOPHER J , CRESPO ALEJANDRO , WILSON JONATHAN E , MCCRACKEN TROY , XU SHIMIN , LI HAITANG
IPC分类号： C07D403/04 , A61K31/513 , A61P25/00 , C07D471/04 , C07D487/04 , C07D498/04
CPC分类号： C07D498/04 , A61P25/00 , C07D403/04 , C07D471/04 , C07D487/04
摘要： The present invention is directed to pyrimidine carboxamide compounds of formula I which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis, Parkinson's disease, Parkinson's disease dementia (PDD), or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.
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公开(公告)号：EP3197900A4
公开(公告)日：2018-03-21
申请号：EP15843683
申请日：2015-09-23
发明人： CAI JIAQIANG , CRESPO ALEJANDRO , DU XIAOXING , DUBOIS BYRON GABRIEL , GUIADEEN DEODIALSINGH , KOTHANDARAMAN SHANKARAN , LIU PING , LIU RONGQIANG , QUAN WEIGUO , SINZ CHRISTOPHER , WANG LIPING
IPC分类号： C07D471/04 , A61K31/497 , A61P7/06 , C07D471/06 , C07D498/04 , C07D498/06 , C07D498/16 , C07D513/04 , C07D513/06
CPC分类号： C07D513/06 , C07D471/04 , C07D471/06 , C07D498/04 , C07D498/06 , C07D498/16 , C07D513/04
摘要： The present invention concerns compounds of formula I or pharmaceutically acceptable salts thereof, which inhibit HIF prolyl hydroxylase, their use for enhancing endogenous production of erythropoietin, and for treating conditions associated with reduced endogenous production of erythropoietin such as anemia and like conditions, as well as pharmaceutical compositions comprising such a compound and a pharmaceutical carrier.
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公开(公告)号：EP3197451A4
公开(公告)日：2018-02-28
申请号：EP15843799
申请日：2015-09-23
发明人： CAI JIAQIANG , CRESPO ALEJANDRO , DU XIAOXING , DUBOIS BYRON GABRIEL , LIU PING , LIU RONGQIANG , QUAN WEIGUO , SINZ CHRISTOPHER , WANG LIPING
IPC分类号： C07D491/04 , A61K31/4355 , A61P7/06 , A61P9/10
CPC分类号： C07D491/048 , A61P7/06 , A61P9/10
摘要： The present invention concerns compounds of formula I or pharmaceutically acceptable salts thereof, which inhibit HIF prolyl hydroxylase, their use for enhancing endogenous production of erythropoietin, and for treating conditions associated with reduced endogenous production of erythropoietin such as anemia and like conditions, as well as pharmaceutical compositions comprising such a compound and a pharmaceutical carrier.
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