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公开(公告)号：EP3204385A4
公开(公告)日：2018-03-28
申请号：EP15848373
申请日：2015-10-08
申请人： MERCK SHARP & DOHME
发明人： UJJAINWALLA FEZ , TAN JOHN QIANG , DANG QUN , SINZ CHRISTOPHER J , WANG MING , CHEN YILI , CAI JIAQIANG
IPC分类号： C07D239/36 , A61P7/06 , C07D413/06
CPC分类号： C07D239/36 , A61P7/06 , C07D413/06
摘要： The present invention concerns compounds of Formula I that inhibit HIF prolyl hydroxylase, their use for enhancing endogenous production of erythropoietin, and for treating conditions associated with reduced endogenous production of erythropoietin such as anemia and like conditions, as well as pharmaceutical compositions comprising such a compound and a pharmaceutical carrier.
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公开(公告)号：EP3204363A4
公开(公告)日：2018-04-04
申请号：EP15849713
申请日：2015-10-08
申请人： MERCK SHARP & DOHME
发明人： UJJAINWALLA FEZ , TAN JOHN QIANG , DANG QUN , SINZ CHRISTOPHER J , CRESPO ALEJANDRO , WANG MING , CHEN YILI , CAI JIAQIANG , WU FAN , DU XIAOXING
IPC分类号： C07D239/26 , A61K31/505 , A61P7/06
CPC分类号： C07D239/36 , C07D239/34 , C07D401/12 , C07D403/12 , C07D405/12
摘要： The present invention concerns compounds of Formula I that inhibit HIF prolyl hydroxylase, their use for enhancing endogenous production of erythropoietin, and for treating conditions associated with reduced endogenous production of erythropoietin such as anemia and like conditions, as well as pharmaceutical compositions comprising such a compound and a pharmaceutical carrier.
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公开(公告)号：EP3270926A4
公开(公告)日：2018-08-01
申请号：EP16765473
申请日：2016-03-11
申请人： MERCK SHARP & DOHME
发明人： SHEN DONG-MING , SINZ CHRISTOPHER J , CRESPO ALEJANDRO , WILSON JONATHAN E , MCCRACKEN TROY , XU SHIMIN , LI HAITANG
IPC分类号： C07D403/04 , A61K31/513 , A61P25/00 , C07D471/04 , C07D487/04 , C07D498/04
CPC分类号： C07D498/04 , A61P25/00 , C07D403/04 , C07D471/04 , C07D487/04
摘要： The present invention is directed to pyrimidine carboxamide compounds of formula I which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis, Parkinson's disease, Parkinson's disease dementia (PDD), or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.
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公开(公告)号：EP3204384A4
公开(公告)日：2018-04-18
申请号：EP15848319
申请日：2015-10-08
申请人： MERCK SHARP & DOHME
发明人： UJJAINWALLA FEZ , TAN JOHN QIANG , DANG QUN , SINZ CHRISTOPHER J , WANG MING , CAI JIAQIANG , DU XIAOXING , CHEN YILI
IPC分类号： C07D471/20 , A61K31/4412 , A61K31/4439 , A61P7/08 , C07D401/14 , C07D471/04
CPC分类号： C07D213/82 , A61P7/08 , C07D401/04
摘要： The present invention concerns compounds of formula I that inhibit HIF prolyl hydroxylase, their use for enhancing endogenous production of erythropoietin, and for treating conditions associated with reduced endogenous production of erythropoietin such as anemia and like conditions, as well as pharmaceutical compositions comprising such a compound and a pharmaceutical carrier.
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5.发明公开
公开(公告)号：EP3087060A4
公开(公告)日：2017-06-14
申请号：EP14873215
申请日：2014-12-17
发明人： SHEN DONG-MING , EGBERTSON MELISSA , BERGER RICHARD , QIAN XIAOXIA , QIAN YIMIN , HARPER BART , YANG MENG , GUO ZACK ZHI QIANG , RADA VANESSA L , WANG DEPING , CERNAK TIMOTHY A , SINZ CHRISTOPHER J , WANG MING , WILSON JONATHAN E , XU SHIMIN
IPC分类号： C07D239/36 , A61K31/513 , A61P25/18 , A61P25/22 , A61P25/28 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14
CPC分类号： C07D239/36 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/04 , C07D417/04 , C07D487/04
摘要： Disclosed are pyrimidine carboxamide compounds of formula (I) which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2), pharmaceutical compositions and uses thereof.
摘要翻译： 公开了可用作治疗剂以治疗与磷酸二酯酶2（PDE2）相关的中枢神经系统病症的式（I）的嘧啶甲酰胺化合物，其药物组合物及其用途。
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