公开(公告)号：EP2734529A4

公开(公告)日：2015-06-03

申请号：EP12814549

申请日：2012-07-19

申请人： MERCK SHARP & DOHME ,  MERCK SHARP & DOHME

发明人： DE MAN ADRIANUS P A ,  STERRENBURG JAN-GERARD ,  RAAIJMAKERS HANS C A ,  KAPTEIN ALLARD ,  OUBRIE ARTHUR ,  REWINKEL JOHANNES B M ,  JANS CHRISTIAAN G J M ,  WIJKMANS JACOBUS C H M ,  BARF TJEERD A ,  COOPER ALAN B ,  KIM RONALD M ,  BOGA SOBHANA BABU ,  ZHU HUGH Y ,  GAO XIAOLEI ,  YAO XIN ,  ANAND RAJAN ,  WU HAO ,  LIU SHILAN ,  YANG CHUNDAO ,  ALHASSAN ABDUL-BASIT ,  WANG JAMES ,  YU YOUNONG ,  LIU JIAN ,  VACCARO HENRY M

IPC分类号： C07D487/04 ,  A61K31/4985 ,  A61P19/08 ,  A61P29/00 ,  A61P31/00 ,  A61P35/00 ,  A61P37/00 ,  C07D519/00

CPC分类号： C07D487/04 ,  A61K31/4985 ,  A61K31/53 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/55 ,  A61K45/06 ,  C07D471/04 ,  C07D513/04 ,  C07D519/00

摘要： The present invention provides 6-5 membered fused pyridine ring compounds according to Formula I or pharmaceutically acceptable salts thereof. or a pharmaceutically acceptable salt thereof or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of 6-5 membered fused pyridine ring compounds in the treatment of Bruton's Tyrosine Kinase (Btk) mediated disorders.