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公开(公告)号：EP2734529A4
公开(公告)日：2015-06-03
申请号：EP12814549
申请日：2012-07-19
发明人： DE MAN ADRIANUS P A , STERRENBURG JAN-GERARD , RAAIJMAKERS HANS C A , KAPTEIN ALLARD , OUBRIE ARTHUR , REWINKEL JOHANNES B M , JANS CHRISTIAAN G J M , WIJKMANS JACOBUS C H M , BARF TJEERD A , COOPER ALAN B , KIM RONALD M , BOGA SOBHANA BABU , ZHU HUGH Y , GAO XIAOLEI , YAO XIN , ANAND RAJAN , WU HAO , LIU SHILAN , YANG CHUNDAO , ALHASSAN ABDUL-BASIT , WANG JAMES , YU YOUNONG , LIU JIAN , VACCARO HENRY M
IPC分类号： C07D487/04 , A61K31/4985 , A61P19/08 , A61P29/00 , A61P31/00 , A61P35/00 , A61P37/00 , C07D519/00
CPC分类号： C07D487/04 , A61K31/4985 , A61K31/53 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K45/06 , C07D471/04 , C07D513/04 , C07D519/00
摘要： The present invention provides 6-5 membered fused pyridine ring compounds according to Formula I or pharmaceutically acceptable salts thereof. or a pharmaceutically acceptable salt thereof or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of 6-5 membered fused pyridine ring compounds in the treatment of Bruton's Tyrosine Kinase (Btk) mediated disorders.
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公开(公告)号：EP2542545A4
公开(公告)日：2013-12-25
申请号：EP11750145
申请日：2011-03-02
发明人： MCCOMAS CASEY CAMERON , LIVERTON NIGEL J , SOLL RICHARD , LI PENG , PENG XUANJIA , WU HAO , NARJES FRANK , HABERMANN JOERG , KOCH UWE , LIU SHILAN
IPC分类号： C07D307/84 , A61K31/343 , A61K45/06 , A61P31/14 , C07D405/04 , C07D405/10 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/10 , C07D413/04 , C07D413/10 , C07D413/14 , C07D417/10 , C07D471/04 , C07D473/00 , C07D487/04 , C07D491/04 , C07D495/04 , C07D498/04 , C07D513/04
CPC分类号： C07D307/84 , A61K31/343 , A61K45/06 , C07D405/04 , C07D405/10 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/10 , C07D413/04 , C07D413/10 , C07D413/14 , C07D417/10 , C07D471/04 , C07D473/00 , C07D487/04 , C07D491/04 , C07D495/04 , C07D498/04 , C07D513/04 , A61K2300/00
摘要： Disclosed are compounds of formula (I) that are used as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.
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公开(公告)号：EP2948431A4
公开(公告)日：2016-10-26
申请号：EP14743190
申请日：2014-01-17
申请人： MERCK SHARP & DOHME
发明人： WU HAO , KIM RONALD M , LIU JIAN , LIU SHILAN , YANG CHUNDAO , ZHENG SHULING
IPC分类号： C07D213/75 , A61K31/4985 , A61K31/519 , A61P35/00
CPC分类号： A61K45/06 , A61K31/4985 , A61K31/519 , C07D473/34 , C07D487/04 , C07D519/00
摘要： The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula I or pharmaceutically acceptable salts thereof. Formula I or a pharmaceutically acceptable salt thereof or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds in the treatment of Btk mediated disorders.
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公开(公告)号：EP2948458A4
公开(公告)日：2016-07-27
申请号：EP14743619
申请日：2014-01-22
申请人： MERCK SHARP & DOHME
发明人： WU HAO , KIM RONALD M , LIU JIAN , GAO XIAOLEI , BOGA SOBHANA BABU , GUIADEEN DEODIALSINGH , KOZLOWSKI JOSEPH , YU WENSHENG , ANAND RAJAN , YU YOUNONG , SELYUTIN OLEG B , GAO YING-DUO , LIU SHILAN , YANG CHUNDAO , WANG HONGJIAN
IPC分类号： C07D519/00 , A61K31/4985 , A61K31/519 , A61K31/5365 , A61K31/5383 , A61P19/02 , A61P29/00 , A61P37/00 , C07D487/04
CPC分类号： C07D491/048 , A61K31/497 , A61K31/4985 , A61K31/506 , A61K31/519 , A61K31/5365 , A61K31/5383 , A61K45/06 , C07D455/02 , C07D471/04 , C07D487/04 , C07D498/04 , C07D519/00
摘要： The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula I or a pharmaceutically acceptable salt thereof or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds in the treatment of Btk mediated disorders.
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