公开(公告)号：EP3122346A4

公开(公告)日：2017-08-23

申请号：EP15769367

申请日：2015-03-23

申请人： MERCK SHARP & DOHME ,  MSD R & D (CHINA) CO LTD

发明人： MITCHELL HELEN ,  FRALEY MARK E ,  COOKE ANDREW J ,  CHEN YI-HENG ,  STUMP CRAIG A ,  ZHANG XU-FANG ,  MCCOMAS CASEY C ,  SCHIRRIPA KATHY ,  MCWHERTER MELODY ,  MERCER SWATI P ,  BABAOGLU KERIM ,  MENG DONGFANG ,  WU JANE ,  LIU PING ,  WOOD HAROLD B ,  BAO JIANMING ,  LI CHUN SING ,  MAO QINGHUA ,  QI ZHIQI

IPC分类号： A61K31/166 ,  A61P35/00 ,  C07D471/04

CPC分类号： C07D491/107 ,  C07C233/66 ,  C07D213/75 ,  C07D231/12 ,  C07D239/42 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04

摘要： The present invention is directed to six membered heteroaryl benzamide compounds of formula (I), which are tropomyosin-related kinase (Trk) family protein kinase inhibitors, and hence are useful in the treatment of pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve growth factor (NGF) receptor TrkA.

摘要翻译： 本发明涉及式（I）的六元杂芳基苯甲酰胺化合物，它们是原肌球蛋白相关激酶（Trk）家族蛋白激酶抑制剂，因此可用于治疗疼痛，炎症，癌症，再狭窄，动脉粥样硬化，银屑病 ，血栓形成，与神经生长因子（NGF）受体TrkA的异常活性有关的与髓鞘形成障碍或脱髓鞘有关的疾病，病症，损伤或功能障碍或疾病或病症。

公开(公告)号：EP2146715A4

公开(公告)日：2011-08-31

申请号：EP08742642

申请日：2008-04-07

申请人： MERCK SHARP & DOHME

发明人： WOOD MICHAEL R ,  KIM JUNE ,  MCWHERTER MELODY ,  SELNICK HAROLD G ,  SCHIRRIPA KATHY

IPC分类号： A61K31/497 ,  C07D235/02 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12 ,  C07D471/04

CPC分类号： C07D235/02 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12 ,  C07D471/04

公开(公告)号：EP3122345A4

公开(公告)日：2017-10-04

申请号：EP15769224

申请日：2015-03-23

申请人： MERCK SHARP & DOHME

发明人： MITCHELL HELEN ,  FRALEY MARK E ,  COOKE ANDREW J ,  STUMP CRAIG A ,  CHEN YI HENG ,  BESHORE DOUGLAS C ,  ZHANG XU-FANG ,  MCCOMAS CASEY C ,  SCHIRRIPA KATHY ,  MCWHERTER MELODY ,  MERCER SWATI P ,  MOORE KEITH P ,  LIU PING ,  WOOD HAROLD B ,  LI CHUN SING ,  MAO QINGHUA

IPC分类号： A61K31/166

CPC分类号： C07D403/12 ,  C07D401/12 ,  C07D403/14 ,  C07D471/04 ,  C07D487/04 ,  C07D513/04

摘要： The present invention is directed to a bicyclic heteroaryl benzamide compounds of formula (I) which are tropomyosin-related kinase (Trk) family protein kinase inhibitors, and hence are useful in the treatment of pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve growth factor (NGF) receptor TrkA.