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1.发明公开TRKA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF 审中-公开TRKA-KINASE-HEMMER，ZUSAMMENSETZUNGEN UND VERFAHRENDAFÜR
公开(公告)号：EP3122346A4
公开(公告)日：2017-08-23
申请号：EP15769367
申请日：2015-03-23
发明人： MITCHELL HELEN , FRALEY MARK E , COOKE ANDREW J , CHEN YI-HENG , STUMP CRAIG A , ZHANG XU-FANG , MCCOMAS CASEY C , SCHIRRIPA KATHY , MCWHERTER MELODY , MERCER SWATI P , BABAOGLU KERIM , MENG DONGFANG , WU JANE , LIU PING , WOOD HAROLD B , BAO JIANMING , LI CHUN SING , MAO QINGHUA , QI ZHIQI
IPC分类号： A61K31/166 , A61P35/00 , C07D471/04
CPC分类号： C07D491/107 , C07C233/66 , C07D213/75 , C07D231/12 , C07D239/42 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04
摘要： The present invention is directed to six membered heteroaryl benzamide compounds of formula (I), which are tropomyosin-related kinase (Trk) family protein kinase inhibitors, and hence are useful in the treatment of pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve growth factor (NGF) receptor TrkA.
摘要翻译： 本发明涉及式（I）的六元杂芳基苯甲酰胺化合物，它们是原肌球蛋白相关激酶（Trk）家族蛋白激酶抑制剂，因此可用于治疗疼痛，炎症，癌症，再狭窄，动脉粥样硬化，银屑病 ，血栓形成，与神经生长因子（NGF）受体TrkA的异常活性有关的与髓鞘形成障碍或脱髓鞘有关的疾病，病症，损伤或功能障碍或疾病或病症。
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公开(公告)号：EP2421370A4
公开(公告)日：2012-12-12
申请号：EP10767743
申请日：2010-04-22
申请人： MERCK SHARP & DOHME
IPC分类号： C07D233/00 , A01N43/82 , A61K31/41 , C07D249/08
CPC分类号： C07D413/04 , C07D413/14
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公开(公告)号：EP3122345A4
公开(公告)日：2017-10-04
申请号：EP15769224
申请日：2015-03-23
申请人： MERCK SHARP & DOHME
发明人： MITCHELL HELEN , FRALEY MARK E , COOKE ANDREW J , STUMP CRAIG A , CHEN YI HENG , BESHORE DOUGLAS C , ZHANG XU-FANG , MCCOMAS CASEY C , SCHIRRIPA KATHY , MCWHERTER MELODY , MERCER SWATI P , MOORE KEITH P , LIU PING , WOOD HAROLD B , LI CHUN SING , MAO QINGHUA
IPC分类号： A61K31/166
CPC分类号： C07D403/12 , C07D401/12 , C07D403/14 , C07D471/04 , C07D487/04 , C07D513/04
摘要： The present invention is directed to a bicyclic heteroaryl benzamide compounds of formula (I) which are tropomyosin-related kinase (Trk) family protein kinase inhibitors, and hence are useful in the treatment of pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve growth factor (NGF) receptor TrkA.
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4.发明公开TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF 审中-公开TRKA-KINASE-HEMMER，ZUSAMMENSETZUNGEN DARAUS UND VERFAHRENDAFÜR
公开(公告)号：EP3046554A4
公开(公告)日：2017-03-08
申请号：EP14845934
申请日：2014-09-17
申请人： MERCK SHARP & DOHME
发明人： COOKE ANDREW J , STUMP CRAIG A , ZHANG XU-FANG , LI CHUN SING , MAO QINGHUA
CPC分类号： C07D213/75 , C07C275/28 , C07D231/40 , C07D233/88 , C07D239/42 , C07D249/08 , C07D257/04 , C07D261/14 , C07D263/32 , C07D271/10 , C07D277/44 , C07D277/48 , C07D285/12 , C07D295/135 , C07D311/88 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/12 , C07D471/04 , C07D487/04 , C07D498/04 , C07D513/04
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公开(公告)号：EP2855477A4
公开(公告)日：2015-11-18
申请号：EP13796299
申请日：2013-05-24
申请人： MERCK SHARP & DOHME
发明人： ALTMAN MICHAEL D , FISCHER CHRISTIAN , KATZ JASON D , WILLIAMS THERESA M , ZHANG XU-FANG , ZHOU HUA
IPC分类号： C07D231/12 , A61K31/437 , A61P25/28 , C07D471/04 , C07D471/08
CPC分类号： C07D471/04 , C07B59/002 , C07B2200/05 , C07D231/12 , C07D471/08
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公开(公告)号：EP2076492A4
公开(公告)日：2010-12-22
申请号：EP07867196
申请日：2007-10-02
申请人： MERCK SHARP & DOHME
IPC分类号： C07D207/337 , A61K31/40 , A61K31/4025 , A61K31/416 , A61K31/427 , A61K31/4439 , A61K31/4709 , A61K31/55 , A61P31/18
CPC分类号： C07D207/36 , C07D401/06 , C07D401/12 , C07D403/12 , C07D409/12 , C07D495/04
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