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公开(公告)号：EP2389226B1
公开(公告)日：2013-11-20
申请号：EP10703543.8
申请日：2010-01-21
发明人： JOSIEN, Hubert, B. , CLADER, John, W. , GREENLEE, William, J. , MAYER, Michael, John , HERR, Robert, Jason , DAVIS, Jason, L. , DENG, Kai , HSIA, Ming Min , WAN, Shuangyi
IPC分类号： A61P3/10 , A61K31/435 , A61K31/427 , C07D417/12 , C07D417/14 , C07D215/233 , C07D217/24
CPC分类号： C07D417/12 , C07D215/233 , C07D417/14
摘要： This invention provides for certain bridged and fused heterocyclic compounds of the formula (I) or a pharmaceutically acceptable salt, ester solvate or prodrug thereof wherein: L is: (II) and the other variables are defined herein; the inventive compounds are agonists of the G-protein coupled receptor 40 (GPR40, also known as free fatty acid receptor FFAR). This invention further relates to pharmaceutical compositions containing these compounds, and the use of these compounds to regulate insulin levels in a mammal. The compounds may be used, for example in the prevention and treatment of Type 2 diabetes mellitus and in the prevention and treatment of conditions related to Type 2 diabetes mellitus, such as insulin resistance, obesity and lipid disorders.
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2.发明授权CARBOCYCLIC AND HETEROCYCLIC ARYLSULFONES AS GAMMA SECRETASE INHIBITORS 有权CARBOCYCLISCHE UND HETEROCYCLISCHE ARYLSULFONE ALS GAMMA-SEKRETASE-HEMMER
公开(公告)号：EP1976843B1
公开(公告)日：2013-09-04
申请号：EP07716750.0
申请日：2007-01-18
发明人： ASBEROM, Theodros , BARA, Thomas , BENNETT, Chad, E. , BURNETT, Duane, A. , CAPLEN, Mary Ann , CLADER, John, W. , COLE, David, J. , DOMALSKI, Martin, S. , JOSIEN, Hubert, B. , KNUTSON, Chad, E. , LI, Hongmei , MCBRIAR, Mark, D. , PISSARNITSKI, Dmitri, A. , QIANG, Li , RAJAGOPALAN, Murali , SASIKUMAR, Thavalakulamgar, K. , SU, Jing , TANG, Haiqun , WU, Wen-Lian , XU, Ruo , ZHAO, Zhiqiang
IPC分类号： C07D311/22 , C07D311/80 , C07D311/92 , C07D311/94 , C07D313/08 , C07D335/06
CPC分类号： C07D311/22 , C07C317/14 , C07C317/20 , C07C317/44 , C07C2602/08 , C07C2602/10 , C07C2602/12 , C07D311/80 , C07D311/92 , C07D311/94 , C07D313/08 , C07D335/06 , C07D405/12 , C07D409/12 , C07D491/04 , C07D493/04
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3.发明授权BENZENESULFONYL-CHROMANE, THIOCHROMANE, TETRAHYDRONAPHTHALENE AND RELATED GAMMA SECRETASE INHIBITORS 有权苯磺酰基色，硫色满，四氢化萘及相关GAMMASEKRETASEHEMMER
公开(公告)号：EP2178882B1
公开(公告)日：2013-04-17
申请号：EP08794506.9
申请日：2008-07-15
发明人： SASIKUMAR, Thavalakulamgara, K. , BURNETT, Duane, A. , ASBEROM, Theodros , WU, Wen-Lian , LI, Hongmei , XU, Ruo , JOSIEN, Hubert, B.
IPC分类号： C07D491/04 , C07D493/04 , C07D513/04 , C07D513/14 , A61K31/542 , A61K31/54 , A61K31/519 , A61K31/35
CPC分类号： C07D493/04 , C07D491/04 , C07D513/04 , C07D513/14
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公开(公告)号：EP3810626A1
公开(公告)日：2021-04-28
申请号：EP19739801.9
申请日：2019-06-20
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公开(公告)号：EP3810129A1
公开(公告)日：2021-04-28
申请号：EP19821895.0
申请日：2019-06-20
发明人： XIONG, Yusheng , TUCKER, Thomas, Joseph , WU, Chengwei , BIANCHI, Elisabetta , BRANCA, Danila , KEREKES, Angela, Dawn , WALJI, Abbas, M. , JOSIEN, Hubert, B. , DING, Fa-Xiang , YOUM, Hyewon , SANTOPRETE, Alessia , INGENITO, Raffaele
IPC分类号： A61K31/395 , A61K31/40 , A61K39/395 , C07D207/00 , C07K16/00 , C07K16/40
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公开(公告)号：EP2389368B1
公开(公告)日：2015-06-17
申请号：EP10703379.7
申请日：2010-01-21
发明人： JOSIEN, Hubert, B. , CLADER, John, W. , GREENLEE, William, J. , MAYER, Michael, John , DAVIS, Jason, L. , WAN, Shuangyi
IPC分类号： C07D263/44 , C07D277/34 , C07D417/04 , C07D417/12 , C07D417/14 , A61K31/421 , A61K31/426 , A61K31/427 , A61K31/4439 , A61K31/502 , A61P3/10
CPC分类号： C07D417/14 , C07D263/44 , C07D277/34 , C07D417/04 , C07D417/12
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公开(公告)号：EP2379563B1
公开(公告)日：2014-07-16
申请号：EP09775507.8
申请日：2009-12-18
发明人： ASBEROM, Theodros , HUANG, Xianhai , ZHU, Zhaoning , CLADER, John, W. , PISSARNITSKI, Dmitri, A. , JOSIEN, Hubert, B. , LI, Hongmei
IPC分类号： C07D498/04 , A61K31/4245 , A61P25/00 , A61P25/28
CPC分类号： C07D498/04
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公开(公告)号：EP2435416B1
公开(公告)日：2016-03-30
申请号：EP08768856.0
申请日：2008-07-01
发明人： WU, Wen-lian , BARA, Thomas, A. , BURNETT, Duane, A. , CLADER, John, W. , DOMALSKI, Martin S. , JIN, Yan , JOSIEN, Hubert, B. , LI, Hongmei , LIANG, Xian , PISSARNITSKI, Dmitri, A. , SASIKUMAR, Thavalakulamgara, K. , WONG, Jesse, K. , XU, Ruo , ZHAO, Zhiqiang , MCNAMARA, Paul
IPC分类号： C07D311/78 , C07D407/12 , C07D493/04 , A61K31/35 , A61K31/352 , A61P25/28
CPC分类号： C07D493/04 , C07D311/78 , C07D407/12
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