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公开(公告)号：EP1019510B1
公开(公告)日：2003-07-16
申请号：EP98946547.1
申请日：1998-10-01
发明人： ALLAN, Gordon , MEEHAN, Brian , CLARK, Edward , ELLIS, John , HAINES, Deborah , HASSARD, Lori , HARDING, John , CHARREYRE, Catherine, Elisabeth , CHAPPUIS, Gilles, Emile , MCNEILLY, Francis
CPC分类号： C07K14/005 , A23C19/0321 , A23C19/0323 , A61K38/00 , A61K39/00 , A61K39/12 , A61K48/00 , A61K2039/51 , A61K2039/5252 , A61K2039/552 , A61K2039/55566 , C12N2750/10021 , C12N2750/10022 , C12N2750/10034 , C12N2750/10043
摘要： The invention concerns porcine circovirus strains isolated from pulmonary and ganglionary specimens derived from livestock suffering from postweaning multisystemic wasting syndrome (PMWS). It concerns purified preparations of said strains, attenuated or inactivated standard vaccines, recombinant live vaccines, plasmid vaccines and subunit vaccines, as well as diagnostic reagents and methods. The invention also concerns DNA fragments useful for producing subunits in a expression vector in vitro or as sequences to be integrated in an expression vector in vivo of virus or plasmid type.
摘要翻译： 本发明涉及从患有断奶后多系统衰竭综合症（PMWS）的牲畜得到的肺和神经节样本分离的猪圆环病毒株。 它涉及所述菌株的纯化制剂，减毒或灭活的标准疫苗，重组活疫苗，质粒疫苗和亚单位疫苗以及诊断试剂和方法。 本发明还涉及可用于在体外表达载体中产生亚基的DNA片段或作为待整合入病毒或质粒类型的体内表达载体中的序列。
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公开(公告)号：EP1019510A1
公开(公告)日：2000-07-19
申请号：EP98946547.1
申请日：1998-10-01
发明人： ALLAN, Gordon , MEEHAN, Brian , CLARK, Edward , ELLIS, John , HAINES, Deborah , HASSARD, Lori , HARDING, John , CHARREYRE, Catherine, Elisabeth , CHAPPUIS, Gilles, Emile , MCNEILLY, Francis
CPC分类号： C07K14/005 , A23C19/0321 , A23C19/0323 , A61K38/00 , A61K39/00 , A61K39/12 , A61K48/00 , A61K2039/51 , A61K2039/5252 , A61K2039/552 , A61K2039/55566 , C12N2750/10021 , C12N2750/10022 , C12N2750/10034 , C12N2750/10043
摘要： The invention concerns porcine circovirus strains isolated from pulmonary and ganglionary specimens derived from livestock suffering from postweaning multisystemic wasting syndrome (PMWS). It concerns purified preparations of said strains, attenuated or inactivated standard vaccines, recombinant live vaccines, plasmid vaccines and subunit vaccines, as well as diagnostic reagents and methods. The invention also concerns DNA fragments useful for producing subunits in a expression vector in vitro or as sequences to be integrated in an expression vector in vivo of virus or plasmid type.
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公开(公告)号：EP1246920B1
公开(公告)日：2011-10-05
申请号：EP00960628.6
申请日：2000-08-28
发明人： ELLIS, John Albert , ALLAN, Gordon, Moore , MEEHAN, Brian , CLARK, Edward , HAINES, Deborah , HASSARD, Lori , HARDING, John , CHARREYRE, Catherine, Elisabeth , CHAPPUIS, Gilles, Emile , KRAKOWKA, George, Steve , AUDONNET, Jean-Christophe, Francis , MCNEILLY, Francis
CPC分类号： C07K14/005 , A61K2039/53 , C12N7/00 , C12N15/86 , C12N2710/24043 , C12N2750/10022
摘要： Porcine circovirus-2 (PCV-2) is a recently identified agent wherein the potential spectrum of PCV-2-associated disease has been expanded by evidence of vertical and sexual transmission and associated reproductive failure in swine populations. PCV-2 was isolated from a litter of aborted piglets from a farm experiencing late term abortions and stillbirths. Severe, diffuse myocarditis was present in one piglet associated with extensive immunohistochemical staining for PCV-2 antigen. Variable amounts of PCV-2 antigen were also present in liver, lung and kidney of multiple fetuses. Inoculation of female pigs with a composition including an immunogen from PCV-2 or an epitope of interest from such an immunogen or with a vector expressing such an immunogen or epitope of interest prior to breeding, such as within the first five weeks of life, or prior to the perinatal period, or repeatedly over a lifetime, or during pregnancy, such as between the 6th and 8th and/or the 10th and 13th weeks of gestation, can prevent myocarditis, abortion and intrauterine infection associated with porcine circovirus-2. In addition, innoculation of male and/or female pigs with the aforementioned compositions can be carried out to prevent transmission of PCV-2 from male to female (or vice versa) during mating. Thus, the invention involves methods and compositions for preventing myocarditis, abortion and intrauterine infection associated with porcine circovirus-2.
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公开(公告)号：EP1246920A2
公开(公告)日：2002-10-09
申请号：EP00960628.6
申请日：2000-08-28
发明人： ELLIS, John Albert , ALLAN, Gordon, Moore , MEEHAN, Brian , CLARK, Edward , HAINES, Deborah , HASSARD, Lori , HARDING, John , CHARREYRE, Catherine, Elisabeth , CHAPPUIS, Gilles, Emile , KRAKOWKA, George, Steve , AUDONNET, Jean-Christophe, Francis , MCNEILLY, Francis
CPC分类号： C07K14/005 , A61K2039/53 , C12N7/00 , C12N15/86 , C12N2710/24043 , C12N2750/10022
摘要： Porcine circovirus-2 (PCV-2) is a recently identified agent wherein the potential spectrum of PCV-2-associated disease has been expanded by evidence of vertical and sexual transmission and associated reproductive failure in swine populations. PCV-2 was isolated from a litter of aborted piglets from a farm experiencing late term abortions and stillbirths. Severe, diffuse myocarditis was present in one piglet associated with extensive immunohistochemical staining for PCV-2 antigen. Variable amounts of PCV-2 antigen were also present in liver, lung and kidney of multiple fetuses. Inoculation of female pigs with a composition including an immunogen from PCV-2 or an epitope of interest from such an immunogen or with a vector expressing such an immunogen or epitope of interest prior to breeding, such as within the first five weeks of life, or prior to the perinatal period, or repeatedly over a lifetime, or during pregnancy, such as between the 6th and 8th and/or the 10th and 13th weeks of gestation, can prevent myocarditis, abortion and intrauterine infection associated with porcine circovirus-2. In addition, innoculation of male and/or female pigs with the aforementioned compositions can be carried out to prevent transmission of PCV-2 from male to female (or vice versa) during mating. Thus, the invention involves methods and compositions for preventing myocarditis, abortion and intrauterine infection associated with porcine circovirus-2.
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