利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

8 条记录 (耗时 0.011 秒)

    Agent for determining manganese and method relating thereto
    2.
    发明公开
    Agent for determining manganese and method relating thereto 失效
    Agenz zur Bestimmung von Mangan und Verfahren in Verbindung damit。

    公开(公告)号：EP0477402A1

    公开(公告)日：1992-04-01

    申请号：EP90118444.0

    申请日：1990-09-26

    申请人： MILES INC.

    发明人： Genshaw, Marvin A. ,  Pugia, Michael J.

    IPC分类号： G01N33/84 ,  G01N33/72 ,  G01N33/52 ,  C12Q1/26

    CPC分类号： G01N33/84 ,  C12Q1/26 ,  G01N33/523 ,  G01N2800/04

    摘要： The present invention is directed to a simple and inexpensive liquid or dry reagent assay system for detecting nanomolar amounts of manganese in body fluids in microgram per liter concentrations. More specifically, the manganese assay of this invention is directed to the optical detection of a chromogenic reaction, such as the oxidation of a redox indicator, catalyzed by a manganese porphyrin complex.

    摘要翻译： 本发明涉及一种用于以毫升/升浓度检测体液中的纳摩尔量的锰的简单廉价的液体或干试剂测定系统。 更具体地，本发明的锰测定涉及由锰卟啉络合物催化的显色反应的光学检测，例如氧化还原指示剂的氧化。

    Volume independent diagnostic device
    4.
    发明公开
    Volume independent diagnostic device 失效
    VolumenunabhängigerTestbehelf。

    公开(公告)号：EP0303784A1

    公开(公告)日：1989-02-22

    申请号：EP88109038.5

    申请日：1988-06-07

    申请人： MILES INC.

    发明人： Burkhardt, Alan E. ,  Genshaw, Marvin A. ,  Stover, Lon R.

    IPC分类号： G01N33/52

    CPC分类号： G01N33/525

    摘要： A process and device for quantitative determination of analyte concentrations in liquid samples. The device includes one or more bibulous matrices constructed and arranged to essentially eliminate sample volume sensitivity from analyte determinations. In accordance with the present invention, the device includes one or more test reagent-treated bibulous matrices covered at least partially by an impermeable coating or film. A liquid sample is applied to the uncovered portion of the bibulous matrix such that the liquid sample is metered into the bibulous matrix by the impermeable coating or film. The sample chromatrographs through the bibulous matrix until the matrix is saturated with liquid. The process is essentially sample volume independent, providing more uniform and accurate quantitative analyte determinations.

    摘要翻译： 用于定量测定液体样品中分析物浓度的方法和装置。 该装置包括一个或多个吸引的基质，其构造和布置为基本上消除了来自分析物测定的样品体积灵敏度。 根据本发明，该装置包括至少部分地被不可渗透的涂层或膜覆盖的一种或多种受试剂处理的吸水性基质。 将液体样品施加到吸水性基质的未覆盖部分，使得液体样品通过不可渗透的涂层或膜计量加入到吸水性基质中。 通过吸水基质的样品色谱仪直到基质用液体饱和。 该过程基本上是样品体积独立的，提供更均匀和准确的定量分析物测定。

    Process and device for separating and testing whole blood
    5.
    发明公开
    Process and device for separating and testing whole blood 失效
    Verfahren und Vorrichtung zum Trennen und Testen von Vollblut。

    公开(公告)号：EP0295526A1

    公开(公告)日：1988-12-21

    申请号：EP88109015.3

    申请日：1988-06-06

    申请人： MILES INC.

    发明人： Genshaw, Marvin A. ,  Stover, Lon R.

    IPC分类号： G01N33/52 ,  C12Q1/56

    CPC分类号： C12Q1/56 ,  G01N33/5002 ,  G01N33/525 ,  G01N33/70 ,  G01N33/728 ,  G01N2333/42 ,  G01N2333/4724 ,  G01N2333/974

    摘要： A process and device for separating plasma or serum from whole blood. The device includes one or more bibulous matrices, treated to separate the serum or plasma from the cellular components of whole blood. In one embodiment of the inven­tion, the separated, undiluted soluble constitu­ents (plasma or serum) from the whole blood sample can then can be analyzed for a particular soluble constituent. The process includes depositing the whole blood on a treated bibulous matrix containing a nonblood specific lectin, a thrombin or mixture thereof, whereby the cellular compon­ents are separated from the whole blood as it permeates through the bibulous matrix. The essen­tially cell-free plasma or serum then passes to an assay area of the same, or an adjacent, bibu­lous matrix for detection of a particular soluble constituent of whole blood.

    摘要翻译： 用于从全血中分离血浆或血清的方法和装置。 该装置包括一个或多个吸取的基质，用于将血清或血浆与全血的细胞组分分离。 在本发明的一个实施方案中，然后可以分析来自全血样品的分离的未稀释的可溶性成分（血浆或血清）以获得特定的可溶性成分。 该方法包括将全血沉积在含有非血清特异性凝集素，凝血酶或其混合物的经处理的吸水性基质上，由此当细胞组分渗透通过吸水性基质时与全血分离。 然后，基本上无细胞的血浆或血清通过相同或相邻的吸水基质的测定区域，以检测全血的特定可溶性成分。

    Test device and method of determining concentration of a sample component
    8.
    发明公开
    Test device and method of determining concentration of a sample component 失效
    分析装置和用于确定样品组分的浓度的方法。

    公开(公告)号：EP0229982A2

    公开(公告)日：1987-07-29

    申请号：EP86117293.0

    申请日：1986-12-11

    申请人： MILES INC.

    发明人： Genshaw, Marvin A.

    IPC分类号： G01N33/52

    CPC分类号： G01N33/521 ,  Y10T436/144444

    摘要： The precision in reflectance or absorption measurements used to determine the presence and concentration of a component in an assay liquid in unexpectedly increased to essentially eliminate the variability of different reactant carriers and variability in reflectance or absorption instruments by including, either within the reactant carrier or within the assay liquid sample, in addition to a primary color forming or color changing indicator, a secondary, inert colorant compound or dye having a light absorption wavelength peak separated from a light absorption wavelength peak of the primary indicator or chromogen by at least 80 nm. To achieve the full advantage of the present invention, the colorant material or marker should be inert to the reactant system in the carrier and should be inert to the assay liquid to provide al light reflectance or light absorption response essentially distinct from the light reflectance response of the primary chromogen to compensate for measurement variability. In this manner, any inaccuracy obtained from a reflectance or absorption measurement of the secon­dary colorant marker, incorporated into the carrier or into the assay sample in known concentration, can be used for compensation of a reflectance or absorp­tion measurement of the primary color formed as a result of interaction or reaction of the test sample with the reagent composition, and, therefore, the concentration measurement of a predetermined compo­nent of the assay liquid.