公开(公告)号：EP1642123B1

公开(公告)日：2018-12-26

申请号：EP04755696.4

申请日：2004-06-18

Applicant: Roche Diabetes Care GmbH ,  F. Hoffmann-La Roche AG

Inventor： BURKE, David, W. ,  KHUN, Lance, S. ,  BEATY, Terry, A. ,  SVETNIK, Vladimir

IPC: G01N27/327 ,  G01N33/487 ,  G01N27/02

CPC classification number: G01N27/3274 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/142222 ,  Y10T436/143333 ,  Y10T436/144444

Abstract: A method of measuring an analyte in a biological fluid comprises applying an excitation signal having a DC component and an AC component. The AC and DC responses are measured; a corrected DC response is determined using the AC response; and a concentration of the analyte is determined based upon the corrected DC response. Other methods and devices are disclosed.

公开(公告)号：EP2069776B1

公开(公告)日：2017-12-13

申请号：EP07813900.3

申请日：2007-08-08

Applicant: Hach Company

Inventor： MORRIS, David Alexander Nathaniel ,  SWANSON, Teresa, Lynn

IPC: G01N21/84 ,  G01N33/18 ,  G01N21/78

CPC classification number: G01N21/78 ,  G01N21/01 ,  G01N21/77 ,  G01N21/8483 ,  G01N31/00 ,  G01N31/22 ,  G01N33/18 ,  Y10T436/144444 ,  Y10T436/2575

Abstract: An apparatus and method of analyzing an aqueous solution, as may be implemented with a hand-held portable electronic device (10). A test pad (32) responsive in color to a characteristic of an aqueous solution is interrogated by the device by measuring, in a plurality of wavelength ranges, intensity values of a test light as reflected off of the test strip. The intensity values may be expressed as values relative to intensities reflected off of white and black calibration surfaces. A relationship among the intensity values for the various wavelength ranges is developed through an algorithm that provides a ratio value that is responsive to the characteristic of the aqueous solution and that is non-responsive to absolute intensity values of the reflected light. The test pad may be supported on an opaque and non-reflective substrate (28) that cooperates with an opaque edge portion (14E) of a test element placement member (14B) and associated side walls (14W) of the device to minimize the impingement of ambient light onto the test pad during interrogation.

公开(公告)号：EP3145390A4

公开(公告)日：2017-11-29

申请号：EP15796223

申请日：2015-05-19

Applicant: ROCHE DIABETES CARE INC ,  ROCHE DIABETES CARE GMBH

Inventor： CARTER ROBERT E ,  SAUERS MATTHEW C

IPC: A61B5/00 ,  A61B5/157 ,  G01N27/327 ,  G01N33/487 ,  G01N33/49

CPC classification number: G01N21/77 ,  A61B5/150022 ,  A61B5/150358 ,  A61B5/157 ,  F21V33/0068 ,  F21W2131/20 ,  G01N27/3272 ,  G01N27/3273 ,  G01N33/48707 ,  G01N33/48785 ,  G01N33/49 ,  Y10T436/144444

Abstract: A handheld medical device is configured to illuminate a test strip inserted therein and may include a housing having a port configured to receive a test strip. A circuit board may be mounted inside the housing. A measurement module may be mounted to the circuit board and may be cooperatively operable with the test strip inserted into the port to measure a sample of fluid residing on the test strip. The circuit board faces an opposing top surface of the test strip inserted into the port. A light source may be mounted on the circuit board and operable to emit light substantially perpendicular to the opposing top surface of the test strip inserted into the port. The light source may project the light along an optical axis substantially perpendicular to the opposing top surface of the test strip and illuminate an area surrounding a dosing end of the test strip.

公开(公告)号：EP2877850B1

公开(公告)日：2017-10-04

申请号：EP13709708.5

申请日：2013-03-05

Applicant: Ascensia Diabetes Care Holdings AG

Inventor： GOFMAN, Igor

IPC: G01N33/487

CPC classification number: G01N33/48785 ,  G01N33/48792 ,  G01N33/49 ,  Y10T436/144444

Abstract: A biosensor meter (10a) is provided for determining an analyte concentration in a fluid. The biosensor meter includes a USB port (14a) having a first data signal port terminal (32d'), and a detection circuit (50a) including a first input terminal and an output terminal. The first input terminal of the detection circuit (50a) is coupled to the first data signal port terminal (32d'). The detection circuit (50a) provides at the output terminal a first output signal when a current sensed at the first input terminal is greater than or equal to a first predetermined amount, and a second output signal when the current sensed at the first input terminal is less than the first predetermined amount. The detection circuit (50a) is configured to detect whether the USB port (14a) of the biosensor meter (10a) is connected to the USB port (14b) of another electronic device, such as a computer (12) and even if the computer (12) is shut down, and to prompt the meter's user for not carrying out a measurement in order to reduce the risk of electrical shock.

Abstract translation: 提供生物传感器仪表（10a）用于确定流体中的分析物浓度，例如血液中的葡萄糖。 生物传感器计量器包括具有第一数据信号端口端子（32d'）的USB端口（14a）和包括第一输入端子和输出端子的检测电路（50a）。 检测电路（50a）的第一输入端子连接到第一数据信号端口（32d'）。 当在第一输入端子处感测到的电流大于或等于第一预定量时，检测电路（50a）在输出端子处提供第一输出信号，并且当在第一输入端子处感测到的电流为第二输出信号时 小于第一预定量。 检测电路被配置为检测生物传感器仪表（10a）的USB端口（14a）是否连接到另一电子装置（例如计算机（12））的USB端口（14b），并提示仪表用户 不进行测量以降低电击风险。

公开(公告)号：EP2936124B1

公开(公告)日：2017-03-15

申请号：EP13811932.6

申请日：2013-12-19

Applicant: Roche Diabetes Care GmbH ,  F. Hoffmann-La Roche AG

Inventor： AIGNER, Simon ,  CHEMNITIUS, Gabriele ,  HORN, Carina ,  LIMBURG, Bernd ,  OTTENSTEIN, Timo ,  PETRICH, Wolfgang ,  PLUM, Markus ,  RINGEMANN, Christian ,  SERR, Markus

IPC: G01N21/77 ,  G01N21/84 ,  G01N21/27

CPC classification number: G06F19/24 ,  G01N21/274 ,  G01N21/77 ,  G01N21/8483 ,  G01N33/66 ,  G01N33/80 ,  G01N2201/129 ,  Y10T436/144444

公开(公告)号：EP2898111B1

公开(公告)日：2016-10-26

申请号：EP13766202.9

申请日：2013-09-12

Applicant: 3M Innovative Properties Company

Inventor： CHEN, Te-Wei ,  HUNG, Huang Chin ,  JING, Naiyong

IPC: C23C18/12

CPC classification number: G01N33/66 ,  C08J7/06 ,  C23C18/1266 ,  Y10T428/24421 ,  Y10T436/144444

Abstract: The present invention provides a hydrophilic film that causes a liquid to diffuse rapidly in a single direction. The hydrophilic film comprises a substrate having a texture of parallel sunken and raised patterns, and a hydrophilic coat comprising a coat of silicon dioxide particles. The present invention also provides a method for preparing the hydrophilic film. The method comprises: preparing an aqueous dispersion of silicon dioxide particles, wherein the average size of the silicon dioxide particles is 1 to 60 nm, and the concentration of the silicon dioxide particles is 0.05% to 15% by weight; coating the aqueous dispersion of silicon dioxide particles on a substrate, wherein the substrate has a texture of parallel sunken and raised patterns; and drying the substrate coated with the aqueous dispersion of silicon dioxide particles.

Abstract translation: 本发明提供使液体在单一方向快速扩散的亲水性膜。 亲水膜包括具有平行凹陷和凸起图案的织构的基底，以及包含二氧化硅颗粒涂层的亲水性涂层。 本发明还提供了一种制备亲水膜的方法。 该方法包括：制备二氧化硅颗粒的水分散体，其中二氧化硅颗粒的平均尺寸为1至60nm，二氧化硅颗粒的浓度为0.05重量％至15重量％; 将二氧化硅颗粒的水性分散体涂布在基材上，其中基材具有平行凹陷和凸起图案的质地; 并干燥涂覆有二氧化硅颗粒的水性分散体的基材。

公开(公告)号：EP3053914A1

公开(公告)日：2016-08-10

申请号：EP16155522.2

申请日：2010-04-08

Applicant: LIGHTSHIP MEDICAL LIMITED

Inventor： Higgs, Timothy Charles

IPC: C07D221/18 ,  C07F5/02 ,  G01N33/58 ,  C09K11/06

CPC classification number: G01N33/582 ,  C07C311/39 ,  C07D221/18 ,  C09B5/14 ,  C09B57/001 ,  C09K11/06 ,  C09K2211/1007 ,  C09K2211/1029 ,  G01N2400/00 ,  Y10T436/144444

Abstract: The invention provides fluorophores of formulae (I) and (II) and also fluorescent sensor compounds comprising fluorophore moieties based on such fluorophores in combination with a receptor moiety:

There is further provided a method of sensing the presence of a target analyte using the fluorescent sensor compound, as well as the use of the fluorescent sensor compounds to sense a target analyte.

Abstract translation: 本发明提供式（I）和（II）的荧光团，以及包含基于这样的荧光团与受体部分组合的荧光团部分的荧光传感器化合物：还提供了一种使用荧光传感器感测目标分析物的存在的方法 化合物，以及使用荧光传感器化合物来感测目标分析物。

公开(公告)号：EP1910833B1

公开(公告)日：2016-04-06

申请号：EP06786269.8

申请日：2006-07-03

Applicant: Polymer Technology Systems, Inc.

Inventor： IRVIN, Benjamin

IPC: G01N33/558

CPC classification number: G01N33/558 ,  Y10T436/144444

Abstract: A method of adjusting a final signal value measured on a lateral flow assay test strip, by: identifying a pre-determined calibration method for the test strip, wherein the pre-determined calibration method corresponds to the manufacturing lot from which the test strip has been made; measuring signal values while performing a lateral flow assay reaction on a test strip; determining a final signal value; and adjusting the final signal value based upon the identified pre-selected calibration method for the test strip.

公开(公告)号：EP2315007B1

公开(公告)日：2016-02-17

申请号：EP10181942.3

申请日：2005-07-01

Applicant: Bayer HealthCare LLC

Inventor： Reynolds, Jeffrey S. ,  Charlton, Steven C. ,  Jung, Sung-Kwon ,  George, Suny J.

IPC: G01N21/77 ,  G01N21/78 ,  G01N21/25 ,  G01N21/47

CPC classification number: G01N21/78 ,  G01N21/251 ,  G01N21/474 ,  G01N21/64 ,  G01N21/6486 ,  G01N21/7703 ,  G01N21/80 ,  G01N33/582 ,  G01N33/583 ,  G01N2021/772 ,  G01N2021/7773 ,  G01N2201/08 ,  Y10T156/1313 ,  Y10T436/144444

公开(公告)号：EP2924436A1

公开(公告)日：2015-09-30

申请号：EP15160916.1

申请日：2015-03-25

Applicant: DiabetOmics, Inc.

Inventor： Nagalla, Srinivasa ,  Bean, Eric

IPC: G01N33/66 ,  G01N33/68

CPC classification number: G01N33/525 ,  G01N21/78 ,  G01N33/66 ,  G01N33/6872 ,  G01N2800/042 ,  G01N2800/56 ,  Y10T436/143333 ,  Y10T436/144444 ,  Y10T436/200833

Abstract: Disclosed herein are methods and tests for diagnosing and/or monitoring a metabolic condition such as diabetes in a subject, wherein the methods and tests measure salivary glycoproteins. Some of the methods are based on the oxidation of glycoproteins in a saliva sample from the subject, for example using sodium metaperiodate, and then detecting the aldehydes generated during oxidation using a chemical detection method. Also disclosed are kits and lateral flow devices for detecting glycoproteins in a saliva sample.

Abstract translation: 本文公开了用于诊断和/或监测受试者中的代谢病症如糖尿病的方法和测试，其中所述方法和测试测量唾液糖蛋白。 一些方法基于来自受试者的唾液样品中糖蛋白的氧化，例如使用偏高碘酸钠，然后使用化学检测方法检测氧化期间产生的醛。 还公开了用于检测唾液样品中的糖蛋白的试剂盒和侧流装置。